Atomistry » Fluorine » PDB 7tiz-7u1m » 7tyq
Atomistry »
  Fluorine »
    PDB 7tiz-7u1m »
      7tyq »

Fluorine in PDB 7tyq: TEAD2 Bound to Compound 1

Protein crystallography data

The structure of TEAD2 Bound to Compound 1, PDB code: 7tyq was solved by C.L.Noland, R.Fong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 74.33 / 1.88
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 114.854, 61.183, 79.951, 90, 111.61, 90
R / Rfree (%) 20.6 / 24.7

Fluorine Binding Sites:

The binding sites of Fluorine atom in the TEAD2 Bound to Compound 1 (pdb code 7tyq). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the TEAD2 Bound to Compound 1, PDB code: 7tyq:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 7tyq

Go back to Fluorine Binding Sites List in 7tyq
Fluorine binding site 1 out of 6 in the TEAD2 Bound to Compound 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of TEAD2 Bound to Compound 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:48.1
occ:1.00
F A:KUI501 0.0 48.1 1.0
C15 A:KUI501 1.3 51.7 1.0
F2 A:KUI501 2.1 53.1 1.0
F1 A:KUI501 2.1 53.7 1.0
C12 A:KUI501 2.4 42.9 1.0
C13 A:KUI501 3.1 40.7 1.0
C11 A:KUI501 3.4 39.3 1.0
CB A:PHE251 3.4 25.6 1.0
CD2 A:LEU387 3.7 25.4 1.0
CG A:PHE251 4.1 28.8 1.0
CG1 A:VAL252 4.2 29.9 1.0
CB A:ALA304 4.2 25.1 1.0
C14 A:KUI501 4.3 36.3 1.0
C10 A:KUI501 4.6 29.0 1.0
CG A:LEU387 4.6 22.6 1.0
CD1 A:LEU387 4.6 29.2 1.0
CD1 A:PHE251 4.6 27.6 1.0
CA A:PHE251 4.7 27.3 1.0
CG2 A:VAL252 4.7 31.2 1.0
CD2 A:PHE251 4.7 29.6 1.0
C A:PHE251 4.7 32.8 1.0
CD2 A:LEU306 4.8 35.3 1.0
N A:VAL252 5.0 27.8 1.0
C9 A:KUI501 5.0 35.5 1.0
CB A:ALA235 5.0 26.1 1.0

Fluorine binding site 2 out of 6 in 7tyq

Go back to Fluorine Binding Sites List in 7tyq
Fluorine binding site 2 out of 6 in the TEAD2 Bound to Compound 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of TEAD2 Bound to Compound 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:53.7
occ:1.00
F1 A:KUI501 0.0 53.7 1.0
C15 A:KUI501 1.3 51.7 1.0
F2 A:KUI501 2.1 53.1 1.0
F A:KUI501 2.1 48.1 1.0
C12 A:KUI501 2.4 42.9 1.0
C13 A:KUI501 2.9 40.7 1.0
C11 A:KUI501 3.5 39.3 1.0
CD2 A:LEU387 3.5 25.4 1.0
CG A:LEU387 4.2 22.6 1.0
C14 A:KUI501 4.2 36.3 1.0
CE1 A:PHE406 4.4 34.1 1.0
C10 A:KUI501 4.7 29.0 1.0
CZ A:PHE406 4.7 36.6 1.0
CD1 A:LEU387 4.8 29.2 1.0
CD2 A:PHE386 4.8 29.4 1.0
CE2 A:PHE428 4.9 24.9 1.0
CE2 A:PHE386 4.9 30.3 1.0
CD2 A:PHE428 4.9 24.1 1.0
C9 A:KUI501 5.0 35.5 1.0

Fluorine binding site 3 out of 6 in 7tyq

Go back to Fluorine Binding Sites List in 7tyq
Fluorine binding site 3 out of 6 in the TEAD2 Bound to Compound 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of TEAD2 Bound to Compound 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:53.1
occ:1.00
F2 A:KUI501 0.0 53.1 1.0
C15 A:KUI501 1.3 51.7 1.0
F1 A:KUI501 2.1 53.7 1.0
F A:KUI501 2.1 48.1 1.0
C12 A:KUI501 2.4 42.9 1.0
C11 A:KUI501 2.7 39.3 1.0
CE2 A:PHE428 3.1 24.9 1.0
CD2 A:PHE428 3.3 24.1 1.0
C13 A:KUI501 3.6 40.7 1.0
CG1 A:VAL252 3.9 29.9 1.0
CZ A:PHE428 4.0 24.7 1.0
C10 A:KUI501 4.1 29.0 1.0
CB A:ALA304 4.2 25.1 1.0
CG A:PHE428 4.3 22.9 1.0
CE1 A:PHE406 4.7 34.1 1.0
CG2 A:VAL252 4.7 31.2 1.0
C14 A:KUI501 4.8 36.3 1.0
CE1 A:PHE428 4.9 24.3 1.0
CB A:VAL252 4.9 26.8 1.0
C9 A:KUI501 5.0 35.5 1.0

Fluorine binding site 4 out of 6 in 7tyq

Go back to Fluorine Binding Sites List in 7tyq
Fluorine binding site 4 out of 6 in the TEAD2 Bound to Compound 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of TEAD2 Bound to Compound 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F501

b:42.6
occ:1.00
F B:KUI501 0.0 42.6 1.0
C15 B:KUI501 1.3 38.9 1.0
F1 B:KUI501 2.1 51.6 1.0
F2 B:KUI501 2.1 52.3 1.0
C12 B:KUI501 2.4 39.6 1.0
C11 B:KUI501 3.1 42.9 1.0
C13 B:KUI501 3.3 50.5 1.0
CD2 B:PHE428 3.9 21.6 1.0
CE2 B:PHE428 3.9 22.8 1.0
CE1 B:PHE406 4.2 40.0 1.0
C10 B:KUI501 4.4 41.0 1.0
CD2 B:LEU387 4.5 47.8 1.0
C14 B:KUI501 4.5 48.9 1.0
CZ B:PHE428 4.6 21.7 1.0
CG B:PHE428 4.7 17.7 1.0
CB B:ALA304 4.7 34.4 1.0
CD2 B:LEU403 4.7 35.4 1.0
CZ B:PHE406 4.7 52.0 1.0
CD1 B:PHE406 4.8 41.5 1.0
C9 B:KUI501 5.0 37.1 1.0

Fluorine binding site 5 out of 6 in 7tyq

Go back to Fluorine Binding Sites List in 7tyq
Fluorine binding site 5 out of 6 in the TEAD2 Bound to Compound 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of TEAD2 Bound to Compound 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F501

b:51.6
occ:1.00
F1 B:KUI501 0.0 51.6 1.0
C15 B:KUI501 1.3 38.9 1.0
F B:KUI501 2.1 42.6 1.0
F2 B:KUI501 2.1 52.3 1.0
C12 B:KUI501 2.4 39.6 1.0
C11 B:KUI501 2.9 42.9 1.0
CG1 B:VAL252 3.4 31.6 1.0
C13 B:KUI501 3.5 50.5 1.0
CB B:PHE251 3.7 35.4 1.0
CB B:ALA304 3.9 34.4 1.0
CE2 B:PHE428 3.9 22.8 1.0
CG2 B:VAL252 3.9 36.8 1.0
CD2 B:PHE428 4.2 21.6 1.0
C10 B:KUI501 4.2 41.0 1.0
CB B:VAL252 4.3 33.1 1.0
C B:PHE251 4.5 37.7 1.0
N B:VAL252 4.5 36.0 1.0
CG B:PHE251 4.7 41.2 1.0
C14 B:KUI501 4.7 48.9 1.0
O B:PHE251 4.8 36.1 1.0
CA B:PHE251 4.8 33.4 1.0
CB B:ALA235 4.8 33.5 1.0
CZ B:PHE428 4.9 21.7 1.0
C9 B:KUI501 5.0 37.1 1.0

Fluorine binding site 6 out of 6 in 7tyq

Go back to Fluorine Binding Sites List in 7tyq
Fluorine binding site 6 out of 6 in the TEAD2 Bound to Compound 1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of TEAD2 Bound to Compound 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F501

b:52.3
occ:1.00
F2 B:KUI501 0.0 52.3 1.0
C15 B:KUI501 1.3 38.9 1.0
F1 B:KUI501 2.1 51.6 1.0
F B:KUI501 2.1 42.6 1.0
C12 B:KUI501 2.3 39.6 1.0
C13 B:KUI501 2.7 50.5 1.0
CD2 B:LEU387 3.1 47.8 1.0
C11 B:KUI501 3.6 42.9 1.0
CB B:PHE251 3.7 35.4 1.0
CD1 B:LEU387 4.0 41.8 1.0
CG B:PHE251 4.0 41.2 1.0
CG B:LEU387 4.0 42.9 1.0
C14 B:KUI501 4.1 48.9 1.0
CD2 B:PHE251 4.2 39.9 1.0
CD2 B:LEU306 4.2 49.5 1.0
CD1 B:PHE251 4.7 40.8 1.0
C10 B:KUI501 4.7 41.0 1.0
CB B:ALA304 4.9 34.4 1.0
C9 B:KUI501 5.0 37.1 1.0
CE2 B:PHE251 5.0 43.1 1.0

Reference:

T.J.Hagenbeek, J.R.Zbieg, C.L.Noland, X.Yao, S.Schmidt, S.Clausen, M.Steffek, W.Lee, P.Beroza, S.Martin, E.Lin, R.Fong, P.Di Lello, M.H.Kubala, J.A.Lacap, M.N.Y.Yang, D.Maddalo, J.T.Lau, L.An, E.Levy, M.N.Lorenzo, H.J.Lee, T.H.Pham, Z.Modrusan, R.Zang, Y.C.Chen, J.Li, M.Hafner, M.T.Chang, J.J.Crawford, A.Dey. Novel Mechanism of Yap-Tead Inhibition Results in Targeted Chromatin Remodeling and Reveals An Expanded Hippo Dependent Landscape in Cancers To Be Published.
Page generated: Wed Jul 16 00:45:02 2025

Last articles

Mn in 9LJU
Mn in 9LJW
Mn in 9LJS
Mn in 9LJR
Mn in 9LJT
Mn in 9LJV
Mg in 9UA2
Mg in 9R96
Mg in 9VM1
Mg in 9P01
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy