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Atomistry » Fluorine » PDB 7tiz-7u1m » 7tz7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7tiz-7u1m » 7tz7 » |
Fluorine in PDB 7tz7: PI3K Alpha in Complex with An InhibitorEnzymatic activity of PI3K Alpha in Complex with An InhibitorProtein crystallography data
The structure of PI3K Alpha in Complex with An Inhibitor, PDB code: 7tz7
was solved by
M.S.Knapp,
J.Tang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the PI3K Alpha in Complex with An Inhibitor
(pdb code 7tz7). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the PI3K Alpha in Complex with An Inhibitor, PDB code: 7tz7: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 7tz7Go back to![]() ![]()
Fluorine binding site 1 out
of 3 in the PI3K Alpha in Complex with An Inhibitor
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 7tz7Go back to![]() ![]()
Fluorine binding site 2 out
of 3 in the PI3K Alpha in Complex with An Inhibitor
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 7tz7Go back to![]() ![]()
Fluorine binding site 3 out
of 3 in the PI3K Alpha in Complex with An Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
R.A.Fairhurst,
P.Furet,
P.Imbach-Weese,
F.Stauffer,
H.Rueeger,
C.Mccarthy,
S.Ripoche,
S.Oswald,
B.Arnaud,
A.Jary,
M.Maira,
C.Schnell,
D.A.Guthy,
M.Wartmann,
M.Kiffe,
S.Desrayaud,
F.Blasco,
T.Widmer,
F.Seiler,
S.Gutmann,
M.Knapp,
G.Caravatti.
Identification of Nvp-CLR457 As An Orally Bioavailable Non-Cns-Penetrant Pan-Class Ia Phosphoinositol-3-Kinase Inhibitor. J.Med.Chem. V. 65 8345 2022.
Page generated: Wed Jul 16 00:45:17 2025
ISSN: ISSN 0022-2623 PubMed: 35500094 DOI: 10.1021/ACS.JMEDCHEM.2C00267 |
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