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Atomistry » Fluorine » PDB 7v3t-7vr7 » 7vdu | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7v3t-7vr7 » 7vdu » |
Fluorine in PDB 7vdu: The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with Compound 1Enzymatic activity of The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with Compound 1
All present enzymatic activity of The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with Compound 1:
2.7.11.22; Protein crystallography data
The structure of The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with Compound 1, PDB code: 7vdu
was solved by
G.Malojcic,
S.L.Clugston,
M.Daniels,
J.C.Harmange,
M.Ledeborer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with Compound 1
(pdb code 7vdu). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with Compound 1, PDB code: 7vdu: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7vduGo back to![]() ![]()
Fluorine binding site 1 out
of 2 in the The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with Compound 1
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 7vduGo back to![]() ![]()
Fluorine binding site 2 out
of 2 in the The Structure of Cyclin-Dependent Kinase 2 (CDK2) in Complex with Compound 1
![]() Mono view ![]() Stereo pair view
Reference:
M.H.Daniels,
G.Malojcic,
S.L.Clugston,
B.Williams,
M.Coeffet-Le Gal,
X.R.Pan-Zhou,
S.Venkatachalan,
J.C.Harmange,
M.Ledeboer.
Discovery and Optimization of Highly Selective Inhibitors of CDK5. J.Med.Chem. V. 65 3575 2022.
Page generated: Wed Jul 16 01:12:49 2025
ISSN: ISSN 0022-2623 PubMed: 35143203 DOI: 10.1021/ACS.JMEDCHEM.1C02069 |
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