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Fluorine in PDB 7wcx: Crystal Structure of FGFR4(V550M) Kinase Domain with 7V

Enzymatic activity of Crystal Structure of FGFR4(V550M) Kinase Domain with 7V

All present enzymatic activity of Crystal Structure of FGFR4(V550M) Kinase Domain with 7V:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of FGFR4(V550M) Kinase Domain with 7V, PDB code: 7wcx was solved by X.J.Chen, Q.M.Lin, S.Y.Dai, Y.H.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.97 / 2.18
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 41.964, 61.342, 60.813, 90, 98.06, 90
R / Rfree (%) 17 / 22.1

Other elements in 7wcx:

The structure of Crystal Structure of FGFR4(V550M) Kinase Domain with 7V also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of FGFR4(V550M) Kinase Domain with 7V (pdb code 7wcx). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of FGFR4(V550M) Kinase Domain with 7V, PDB code: 7wcx:

Fluorine binding site 1 out of 1 in 7wcx

Go back to Fluorine Binding Sites List in 7wcx
Fluorine binding site 1 out of 1 in the Crystal Structure of FGFR4(V550M) Kinase Domain with 7V


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of FGFR4(V550M) Kinase Domain with 7V within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F801

b:25.4
occ:1.00
FBG A:90F801 0.0 25.4 1.0
CAM A:90F801 1.3 23.8 1.0
CAN A:90F801 2.3 26.1 1.0
CAL A:90F801 2.4 19.6 1.0
NAK A:90F801 2.7 20.5 1.0
CAF A:90F801 3.1 20.0 1.0
CAY A:90F801 3.2 22.7 1.0
CD2 A:LEU619 3.2 21.4 1.0
CAZ A:90F801 3.2 27.7 1.0
CAI A:90F801 3.4 22.6 1.0
NAX A:90F801 3.4 28.4 1.0
CAE A:90F801 3.5 20.8 1.0
CAT A:90F801 3.6 26.7 1.0
CAO A:90F801 3.6 32.9 1.0
CAQ A:90F801 3.6 28.4 1.0
CA A:GLY556 3.7 17.5 1.0
CAW A:90F801 3.8 25.1 1.0
CAV A:90F801 3.8 21.5 1.0
N A:ASN557 3.8 21.2 1.0
C A:GLY556 3.9 16.4 1.0
CL2 A:90F801 4.0 34.6 1.0
CAP A:90F801 4.1 28.4 1.0
CD1 A:LEU619 4.2 20.9 1.0
CG A:LEU619 4.3 16.8 1.0
CAA A:90F801 4.3 21.1 1.0
O A:HOH1013 4.4 19.9 1.0
CAS A:90F801 4.4 23.9 1.0
O A:GLY556 4.6 22.5 1.0
CA A:ASN557 4.6 17.7 1.0
NAH A:90F801 4.6 22.1 1.0
NAR A:90F801 4.7 23.5 1.0
NBF A:90F801 4.7 36.0 1.0
CB A:ASN557 4.7 20.7 1.0
OAJ A:90F801 4.8 20.9 1.0
N A:GLY556 4.8 21.0 1.0
CAD A:90F801 4.8 18.5 1.0
CBL A:90F801 4.9 52.4 1.0
CB A:LEU619 4.9 23.5 1.0

Reference:

M.Shao, X.Chen, F.Yang, X.Song, Y.Zhou, Q.Lin, Y.Fu, R.Ortega, X.Lin, Z.Tu, A.V.Patterson, J.B.Smaill, Y.Chen, X.Lu. Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives As Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4. J.Med.Chem. V. 65 5113 2022.
ISSN: ISSN 0022-2623
PubMed: 35271262
DOI: 10.1021/ACS.JMEDCHEM.2C00096
Page generated: Wed Jul 16 01:27:53 2025

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