Fluorine in PDB 7xj1: Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry

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>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30;

Binding sites:

The binding sites of Fluorine atom in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry (pdb code 7xj1). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 30 binding sites of Fluorine where determined in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry, PDB code: 7xj1:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ B:F1602 b:34.4 occ:1.00 F02 B:EQK1602 0.0 34.4 1.0 C26 B:EQK1602 1.4 34.4 1.0 F04 B:EQK1602 2.2 34.4 1.0 F03 B:EQK1602 2.2 34.4 1.0 C22 B:EQK1602 2.4 34.4 1.0 C20 B:EQK1602 3.0 34.4 1.0 C16 B:EQK1602 3.0 34.4 1.0 C21 B:EQK1602 3.1 34.4 1.0 CD1 C:LEU642 3.4 46.2 1.0 CG1 C:VAL662 3.6 27.9 1.0 O B:ILE637 3.7 35.4 1.0 N09 B:EQK1602 3.8 34.4 1.0 CB C:VAL662 4.0 27.9 1.0 C17 B:EQK1602 4.0 34.4 1.0 CG1 C:ILE659 4.0 28.0 1.0 C24 B:EQK1602 4.1 34.4 1.0 CG2 C:ILE659 4.2 28.0 1.0 CG2 C:VAL662 4.3 27.9 1.0 S01 B:EQK1602 4.4 34.4 1.0 CG C:LEU642 4.5 46.2 1.0 CB C:ILE659 4.5 28.0 1.0 CA C:ILE659 4.5 28.0 1.0 C B:ILE637 4.6 35.4 1.0 C25 B:EQK1602 4.7 34.4 1.0 C15 B:EQK1602 4.8 34.4 1.0 N08 B:EQK1602 4.8 34.4 1.0 O C:ILE659 4.9 28.0 1.0 CD2 C:LEU642 4.9 46.2 1.0

Fluorine binding site 2 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ B:F1602 b:34.4 occ:1.00 F03 B:EQK1602 0.0 34.4 1.0 C26 B:EQK1602 1.4 34.4 1.0 F04 B:EQK1602 2.2 34.4 1.0 F02 B:EQK1602 2.2 34.4 1.0 C22 B:EQK1602 2.4 34.4 1.0 N09 B:EQK1602 2.9 34.4 1.0 CG2 C:ILE659 3.4 28.0 1.0 O B:ILE637 3.7 35.4 1.0 C20 B:EQK1602 3.7 34.4 1.0 CA B:ILE637 4.1 35.4 1.0 C B:ILE637 4.2 35.4 1.0 CG1 C:ILE659 4.2 28.0 1.0 C25 B:EQK1602 4.3 34.4 1.0 CB C:ILE659 4.3 28.0 1.0 CG1 C:ILE663 4.4 30.1 1.0 CG1 B:ILE637 4.4 35.4 1.0 CD1 C:ILE663 4.5 30.1 1.0 C16 B:EQK1602 4.5 34.4 1.0 CB B:ILE637 4.7 35.4 1.0 S01 B:EQK1602 4.7 34.4 1.0 CG2 B:ILE637 4.8 35.4 1.0 O C:ILE659 4.9 28.0 1.0 CA C:ILE659 4.9 28.0 1.0 CG1 C:VAL662 4.9 27.9 1.0 C21 B:EQK1602 5.0 34.4 1.0 O B:THR636 5.0 31.6 1.0

Fluorine binding site 3 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ B:F1602 b:34.4 occ:1.00 F04 B:EQK1602 0.0 34.4 1.0 C26 B:EQK1602 1.4 34.4 1.0 F03 B:EQK1602 2.2 34.4 1.0 F02 B:EQK1602 2.2 34.4 1.0 C22 B:EQK1602 2.3 34.4 1.0 CG1 C:VAL662 3.2 27.9 1.0 C20 B:EQK1602 3.2 34.4 1.0 N09 B:EQK1602 3.5 34.4 1.0 C16 B:EQK1602 3.6 34.4 1.0 C24 A:EQK1801 3.6 42.7 1.0 CG1 C:ILE663 3.9 30.1 1.0 C17 B:EQK1602 3.9 34.4 1.0 CB C:VAL662 4.0 27.9 1.0 C21 A:EQK1801 4.1 42.7 1.0 F03 A:EQK1801 4.3 42.7 1.0 C21 B:EQK1602 4.4 34.4 1.0 S01 B:EQK1602 4.5 34.4 1.0 F02 A:EQK1801 4.5 42.7 1.0 C25 B:EQK1602 4.5 34.4 1.0 N08 A:EQK1801 4.6 42.7 1.0 N C:ILE663 4.6 30.1 1.0 CG2 C:ILE659 4.6 28.0 1.0 CD1 C:ILE663 4.7 30.1 1.0 O C:ILE659 4.7 28.0 1.0 C C:VAL662 4.8 27.9 1.0 CA C:ILE663 4.9 30.1 1.0 C15 B:EQK1602 5.0 34.4 1.0 CG2 C:VAL662 5.0 27.9 1.0

Fluorine binding site 4 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ B:F1603 b:38.9 occ:1.00 F02 B:EQK1603 0.0 38.9 1.0 C26 B:EQK1603 1.4 38.9 1.0 F03 B:EQK1603 2.2 38.9 1.0 F04 B:EQK1603 2.2 38.9 1.0 CE2 A:PHE590 2.3 43.2 1.0 C22 B:EQK1603 2.4 38.9 1.0 CZ A:PHE590 2.8 43.2 1.0 C20 B:EQK1603 3.0 38.9 1.0 C16 B:EQK1603 3.1 38.9 1.0 CD2 A:PHE590 3.4 43.2 1.0 C21 B:EQK1603 3.7 38.9 1.0 C17 B:EQK1603 3.7 38.9 1.0 N09 B:EQK1603 3.7 38.9 1.0 CE1 A:PHE590 4.2 43.2 1.0 CD2 A:LEU669 4.3 40.7 1.0 S01 B:EQK1603 4.4 38.9 1.0 CD2 A:LEU591 4.4 40.8 1.0 C24 B:EQK1603 4.6 38.9 1.0 C15 B:EQK1603 4.6 38.9 1.0 CG A:PHE590 4.6 43.2 1.0 C25 B:EQK1603 4.7 38.9 1.0 CD1 A:PHE590 4.9 43.2 1.0 N08 B:EQK1603 5.0 38.9 1.0 CG1 B:ILE663 5.0 34.0 1.0

Fluorine binding site 5 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ B:F1603 b:38.9 occ:1.00 F03 B:EQK1603 0.0 38.9 1.0 C26 B:EQK1603 1.4 38.9 1.0 F04 B:EQK1603 2.2 38.9 1.0 F02 B:EQK1603 2.2 38.9 1.0 C22 B:EQK1603 2.4 38.9 1.0 N09 B:EQK1603 2.9 38.9 1.0 CZ A:PHE590 3.7 43.2 1.0 C20 B:EQK1603 3.7 38.9 1.0 CE2 A:PHE590 3.8 43.2 1.0 CE1 A:TYR594 3.9 36.1 1.0 CE1 A:PHE633 4.2 29.9 1.0 CD1 A:TYR594 4.2 36.1 1.0 CZ A:TYR594 4.2 36.1 1.0 CG2 A:THR636 4.2 31.4 1.0 C25 B:EQK1603 4.3 38.9 1.0 C16 B:EQK1603 4.5 38.9 1.0 OH A:TYR594 4.6 36.1 1.0 CG2 A:ILE637 4.7 31.9 1.0 CD1 A:PHE633 4.7 29.9 1.0 S01 B:EQK1603 4.7 38.9 1.0 CE2 A:TYR594 4.8 36.1 1.0 CG A:TYR594 4.8 36.1 1.0 CD2 A:LEU669 4.8 40.7 1.0 CD2 A:LEU591 4.8 40.8 1.0 C21 B:EQK1603 5.0 38.9 1.0

Fluorine binding site 6 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ B:F1603 b:38.9 occ:1.00 F04 B:EQK1603 0.0 38.9 1.0 C26 B:EQK1603 1.4 38.9 1.0 F03 B:EQK1603 2.2 38.9 1.0 F02 B:EQK1603 2.2 38.9 1.0 C22 B:EQK1603 2.4 38.9 1.0 C20 B:EQK1603 3.2 38.9 1.0 CG1 B:ILE663 3.3 34.0 1.0 C21 B:EQK1603 3.3 38.9 1.0 C16 B:EQK1603 3.4 38.9 1.0 N09 B:EQK1603 3.6 38.9 1.0 CD1 B:ILE663 4.0 34.0 1.0 CB B:ILE663 4.3 34.0 1.0 C24 B:EQK1603 4.4 38.9 1.0 CE2 A:PHE590 4.4 43.2 1.0 S01 B:EQK1603 4.4 38.9 1.0 CA B:ILE663 4.5 34.0 1.0 CG2 B:ILE663 4.5 34.0 1.0 CE1 A:PHE633 4.5 29.9 1.0 CD1 B:PHE666 4.6 49.1 1.0 C25 B:EQK1603 4.6 38.9 1.0 C17 B:EQK1603 4.6 38.9 1.0 CD2 A:LEU591 4.8 40.8 1.0 CG2 A:ILE637 4.9 31.9 1.0 CZ A:PHE590 4.9 43.2 1.0

Fluorine binding site 7 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ C:F1101 b:35.4 occ:1.00 F02 C:EQK1101 0.0 35.4 1.0 C26 C:EQK1101 1.4 35.4 1.0 F04 C:EQK1101 2.2 35.4 1.0 F03 C:EQK1101 2.2 35.4 1.0 C22 C:EQK1101 2.3 35.4 1.0 N09 C:EQK1101 2.9 35.4 1.0 CD2 B:LEU553 3.3 39.3 1.0 C20 C:EQK1101 3.7 35.4 1.0 CE2 C:PHE656 3.9 32.6 1.0 O B:LEU553 4.1 39.3 1.0 CB B:ALA556 4.2 34.7 1.0 C25 C:EQK1101 4.2 35.4 1.0 CZ C:PHE656 4.3 32.6 1.0 N B:LEU557 4.4 36.5 1.0 C16 C:EQK1101 4.5 35.4 1.0 CB B:LEU557 4.6 36.5 1.0 S01 C:EQK1101 4.7 35.4 1.0 CG B:LEU553 4.7 39.3 1.0 CA B:LEU553 4.7 39.3 1.0 CA B:LEU557 4.7 36.5 1.0 CD2 C:LEU657 4.7 29.9 1.0 C21 C:EQK1101 4.8 35.4 1.0 C B:ALA556 4.8 34.7 1.0 CB B:LEU553 4.8 39.3 1.0 C B:LEU553 4.8 39.3 1.0 CD1 B:LEU557 4.9 36.5 1.0

Fluorine binding site 8 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ C:F1101 b:35.4 occ:1.00 F03 C:EQK1101 0.0 35.4 1.0 C26 C:EQK1101 1.4 35.4 1.0 F04 C:EQK1101 2.2 35.4 1.0 F02 C:EQK1101 2.2 35.4 1.0 C22 C:EQK1101 2.4 35.4 1.0 C20 C:EQK1101 3.0 35.4 1.0 C21 C:EQK1101 3.0 35.4 1.0 CZ C:PHE656 3.0 32.6 1.0 C16 C:EQK1101 3.0 35.4 1.0 CE2 C:PHE656 3.4 32.6 1.0 N09 C:EQK1101 3.8 35.4 1.0 C24 C:EQK1101 4.0 35.4 1.0 C17 C:EQK1101 4.0 35.4 1.0 CE1 C:PHE656 4.2 32.6 1.0 S01 C:EQK1101 4.4 35.4 1.0 CD2 B:LEU553 4.7 39.3 1.0 C25 C:EQK1101 4.7 35.4 1.0 CD2 C:PHE656 4.7 32.6 1.0 N08 C:EQK1101 4.8 35.4 1.0 C15 C:EQK1101 4.8 35.4 1.0

Fluorine binding site 9 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ C:F1101 b:35.4 occ:1.00 F04 C:EQK1101 0.0 35.4 1.0 C26 C:EQK1101 1.4 35.4 1.0 F02 C:EQK1101 2.2 35.4 1.0 F03 C:EQK1101 2.2 35.4 1.0 C22 C:EQK1101 2.4 35.4 1.0 CD1 B:LEU557 3.1 36.5 1.0 C20 C:EQK1101 3.3 35.4 1.0 N09 C:EQK1101 3.4 35.4 1.0 C21 C:EQK1101 3.4 35.4 1.0 C16 C:EQK1101 3.8 35.4 1.0 CB B:LEU557 3.9 36.5 1.0 CG B:LEU557 3.9 36.5 1.0 CD2 B:LEU557 4.2 36.5 1.0 CA B:LEU557 4.3 36.5 1.0 C25 C:EQK1101 4.5 35.4 1.0 S01 C:EQK1101 4.5 35.4 1.0 N B:LEU557 4.7 36.5 1.0 C24 C:EQK1101 4.7 35.4 1.0 O B:LEU553 4.9 39.3 1.0

Fluorine binding site 10 out of 30 in the Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Structure of Human TRPV3_G573S in Complex with Trpvicin in C2 Symmetry within 5.0Å range: probe atom residue distance (Å) B Occ C:F1105 b:43.3 occ:1.00 F02 C:EQK1105 0.0 43.3 1.0 C26 C:EQK1105 1.4 43.3 1.0 F03 C:EQK1105 2.2 43.3 1.0 F04 C:EQK1105 2.2 43.3 1.0 C22 C:EQK1105 2.3 43.3 1.0 N09 C:EQK1105 2.9 43.3 1.0 O05 C:EQK1106 3.1 38.4 1.0 C25 D:EQK1103 3.2 33.9 1.0 N10 D:EQK1103 3.3 33.9 1.0 S01 D:EQK1103 3.3 33.9 1.0 C32 C:EQK1106 3.4 38.4 1.0 C20 C:EQK1105 3.7 43.3 1.0 C27 D:EQK1103 3.7 33.9 1.0 O06 D:EQK1103 3.8 33.9 1.0 O07 D:EQK1103 4.0 33.9 1.0 CE2 D:PHE666 4.0 49.1 1.0 N09 D:EQK1103 4.0 33.9 1.0 C20 D:EQK1103 4.2 33.9 1.0 C25 C:EQK1105 4.2 43.3 1.0 CD2 D:LEU669 4.3 44.7 1.0 C29 C:EQK1106 4.4 38.4 1.0 C16 C:EQK1105 4.4 43.3 1.0 CZ D:PHE666 4.5 49.1 1.0 C22 D:EQK1103 4.5 33.9 1.0 C28 D:EQK1103 4.6 33.9 1.0 C30 D:EQK1103 4.6 33.9 1.0 C33 D:EQK1103 4.7 33.9 1.0 S01 C:EQK1105 4.7 43.3 1.0 C21 C:EQK1105 4.7 43.3 1.0 CD2 D:PHE666 5.0 49.1 1.0

J.Fan, L.Hu, Z.Yue, D.Liao, F.Guo, H.Ke, D.Jiang, Y.Yang, X.Lei. Structural Basis of TRPV3 Inhibition By An Antagonist. Nat.Chem.Biol. 2022.
ISSN: ESSN 1552-4469
PubMed: 36302896
DOI: 10.1038/S41589-022-01166-5