Fluorine in PDB 7yac: Paltusotine-Bound SSTR2-Gi Complex

The binding sites of Fluorine atom in the Paltusotine-Bound SSTR2-Gi Complex (pdb code 7yac). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Paltusotine-Bound SSTR2-Gi Complex, PDB code: 7yac:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Paltusotine-Bound SSTR2-Gi Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Paltusotine-Bound SSTR2-Gi Complex within 5.0Å range: probe atom residue distance (Å) B Occ E:F401 b:107.2 occ:1.00 F24 E:IUD401 0.0 107.2 1.0 C22 E:IUD401 1.4 107.2 1.0 C23 E:IUD401 2.4 107.2 1.0 C21 E:IUD401 2.4 107.2 1.0 C20 E:IUD401 3.7 107.2 1.0 C18 E:IUD401 3.7 107.2 1.0 OH E:TYR50 3.9 120.2 1.0 CG2 E:VAL103 3.9 123.0 1.0 OD1 E:ASP295 4.0 119.0 1.0 C19 E:IUD401 4.1 107.2 1.0 CE1 E:PHE294 4.4 119.3 1.0 CG2 E:VAL298 4.6 109.3 1.0 CG1 E:VAL298 4.6 109.3 1.0 CG E:GLN102 4.7 121.4 1.0 F25 E:IUD401 4.8 107.2 1.0 CD2 E:LEU99 4.8 115.8 1.0 O E:LEU99 4.8 115.8 1.0 CB E:VAL298 4.9 109.3 1.0 C17 E:IUD401 4.9 107.2 1.0 CD1 E:PHE294 4.9 119.3 1.0 CG E:ASP295 5.0 119.0 1.0 CZ E:TYR50 5.0 120.2 1.0

Fluorine binding site 2 out of 2 in the Paltusotine-Bound SSTR2-Gi Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Paltusotine-Bound SSTR2-Gi Complex within 5.0Å range: probe atom residue distance (Å) B Occ E:F401 b:107.2 occ:1.00 F25 E:IUD401 0.0 107.2 1.0 C20 E:IUD401 1.4 107.2 1.0 C21 E:IUD401 2.4 107.2 1.0 C19 E:IUD401 2.4 107.2 1.0 CG E:LEU99 3.2 115.8 1.0 CB E:GLN102 3.3 121.4 1.0 CA E:LEU99 3.5 115.8 1.0 CB E:LEU99 3.6 115.8 1.0 C22 E:IUD401 3.6 107.2 1.0 C18 E:IUD401 3.6 107.2 1.0 CG E:GLN102 3.7 121.4 1.0 CD1 E:LEU99 3.9 115.8 1.0 O E:LEU99 4.0 115.8 1.0 C23 E:IUD401 4.1 107.2 1.0 CD2 E:LEU99 4.2 115.8 1.0 C E:LEU99 4.2 115.8 1.0 N E:LEU99 4.5 115.8 1.0 OE1 E:GLN102 4.5 121.4 1.0 CD E:GLN102 4.6 121.4 1.0 CZ3 E:TRP108 4.6 132.3 1.0 O E:PHE98 4.6 116.7 1.0 CB E:CYS193 4.7 123.9 1.0 CA E:GLN102 4.7 121.4 1.0 F24 E:IUD401 4.8 107.2 1.0 SG E:CYS193 4.9 123.9 1.0 N E:GLN102 4.9 121.4 1.0 C17 E:IUD401 4.9 107.2 1.0 C E:PHE98 4.9 116.7 1.0

J.Zhao, H.Fu, J.Yu, W.Hong, X.Tian, J.Qi, S.Sun, C.Zhao, C.Wu, Z.Xu, L.Cheng, R.Chai, W.Yan, X.Wei, Z.Shao. Prospect of Acromegaly Therapy: Molecular Mechanism of Clinical Drugs Octreotide and Paltusotine. Nat Commun V. 14 962 2023.
ISSN: ESSN 2041-1723
PubMed: 36810324
DOI: 10.1038/S41467-023-36673-Z