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Fluorine in PDB 8ax3: Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride
Enzymatic activity of Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride
All present enzymatic activity of Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride:
3.2.1.104; 3.2.1.45;
3.2.1.104; 3.2.1.45;
Protein crystallography data
The structure of Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride, PDB code: 8ax3
was solved by
R.J.Rowland,
G.J.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 51.82 / 1.59 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 52.92, 155.984, 68.036, 90, 101.96, 90 |
| R / Rfree (%) | 18.2 / 21.3 |
Other elements in 8ax3:
The structure of Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
| Calcium | (Ca) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride
(pdb code 8ax3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride, PDB code: 8ax3:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride, PDB code: 8ax3:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 8ax3
Go back to
Fluorine Binding Sites List in 8ax3
Fluorine binding site 1 out
of 4 in the Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 8ax3
Go back to
Fluorine Binding Sites List in 8ax3
Fluorine binding site 2 out
of 4 in the Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 8ax3
Go back to
Fluorine Binding Sites List in 8ax3
Fluorine binding site 3 out
of 4 in the Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 8ax3
Go back to
Fluorine Binding Sites List in 8ax3
Fluorine binding site 4 out
of 4 in the Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Structure of Recombinant Human Beta-Glucocerebrosidase in Complex with L-Carbaxylosyl Fluoride within 5.0Å range:
|
Reference:
S.Bhosale,
S.Kandalkar,
P.A.Gilormini,
O.Akintola,
R.J.Rowland,
P.J.P.Adabala,
D.King,
M.C.Deen,
K.Xi,
G.J.Davies,
D.J.Vocadlo,
A.J.Bennet.
Single Turnover Covalent Inhibitors For Functional Chaperoning of Lysosomal Glycoside Hydrolases To Be Published.
Page generated: Wed Jul 16 02:42:58 2025
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