Fluorine in PDB 8d7u: Cereblon~DDB1 Bound to Cc-92480 with DDB1 in the Linear Conformation

The structure of Cereblon~DDB1 Bound to Cc-92480 with DDB1 in the Linear Conformation also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Fluorine atom in the Cereblon~DDB1 Bound to Cc-92480 with DDB1 in the Linear Conformation (pdb code 8d7u). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cereblon~DDB1 Bound to Cc-92480 with DDB1 in the Linear Conformation, PDB code: 8d7u:

Fluorine binding site 1 out of 1 in the Cereblon~DDB1 Bound to Cc-92480 with DDB1 in the Linear Conformation


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cereblon~DDB1 Bound to Cc-92480 with DDB1 in the Linear Conformation within 5.0Å range: probe atom residue distance (Å) B Occ B:F502 b:50.1 occ:1.00 F B:QFC502 0.0 50.1 1.0 C B:QFC502 1.4 50.1 1.0 C1 B:QFC502 2.3 50.1 1.0 C5 B:QFC502 2.4 50.1 1.0 N B:QFC502 2.8 50.1 1.0 C6 B:QFC502 3.0 50.1 1.0 ND1 B:HIS353 3.1 38.1 1.0 C30 B:QFC502 3.2 50.1 1.0 C2 B:QFC502 3.6 50.1 1.0 C4 B:QFC502 3.6 50.1 1.0 CE1 B:HIS353 3.8 38.1 1.0 O B:PRO352 4.1 41.0 1.0 C3 B:QFC502 4.1 50.1 1.0 CG B:HIS353 4.3 38.1 1.0 C7 B:QFC502 4.3 50.1 1.0 CA B:HIS353 4.3 38.1 1.0 CE2 B:PHE102 4.3 51.8 1.0 C29 B:QFC502 4.4 50.1 1.0 N1 B:QFC502 4.5 50.1 1.0 CZ B:PHE102 4.5 51.8 1.0 CB B:HIS353 4.6 38.1 1.0 C31 B:QFC502 4.8 50.1 1.0 C B:PRO352 4.8 41.0 1.0 CD2 B:PHE102 4.9 51.8 1.0 N B:HIS353 5.0 38.1 1.0

E.R.Watson, S.J.Novick, M.E.Matyskiela, P.P.Chamberlain, A.H.De La Pena, J.Y.Zhu, E.Tran, P.R.Griffin, I.E.Wertz, G.C.Lander. Molecular Glue Celmod Compounds Are Allosteric Regulators of Cereblon Conformation Biorxiv 2022.
DOI: 10.1101/2022.07.02.498551