Atomistry » Fluorine » PDB 8e90-8eyv » 8el0
Atomistry »
  Fluorine »
    PDB 8e90-8eyv »
      8el0 »

Fluorine in PDB 8el0: Structure of Mbp-Mcl-1 in Complex with A Macrocyclic Compound

Protein crystallography data

The structure of Structure of Mbp-Mcl-1 in Complex with A Macrocyclic Compound, PDB code: 8el0 was solved by R.A.Judge, A.S.Judd, A.J.Souers, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 79.69 / 1.92
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 97.99, 136.943, 38.387, 90, 90, 90
R / Rfree (%) 19.3 / 22.4

Other elements in 8el0:

The structure of Structure of Mbp-Mcl-1 in Complex with A Macrocyclic Compound also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of Mbp-Mcl-1 in Complex with A Macrocyclic Compound (pdb code 8el0). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Mbp-Mcl-1 in Complex with A Macrocyclic Compound, PDB code: 8el0:

Fluorine binding site 1 out of 1 in 8el0

Go back to Fluorine Binding Sites List in 8el0
Fluorine binding site 1 out of 1 in the Structure of Mbp-Mcl-1 in Complex with A Macrocyclic Compound


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Mbp-Mcl-1 in Complex with A Macrocyclic Compound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F4000

b:56.1
occ:1.00
F A:WLW4000 0.0 56.1 1.0
C46 A:WLW4000 1.4 55.4 1.0
C47 A:WLW4000 2.3 54.7 1.0
C45 A:WLW4000 2.3 55.0 1.0
CD1 A:LEU235 2.8 87.8 1.0
CD2 A:LEU235 3.0 87.9 1.0
CG1 A:VAL249 3.3 65.8 1.0
CG A:LEU235 3.4 87.2 1.0
CB A:VAL249 3.6 65.2 1.0
C48 A:WLW4000 3.6 54.0 1.0
C44 A:WLW4000 3.6 54.1 1.0
SD A:MET231 4.0 69.7 1.0
C43 A:WLW4000 4.1 53.3 1.0
CD1 A:LEU246 4.2 76.3 1.0
CG2 A:VAL249 4.4 65.6 1.0
CG A:MET231 4.5 68.4 1.0
O A:LEU246 4.5 72.1 1.0
CE2 A:PHE270 4.7 42.8 1.0
CB A:LEU235 4.8 85.5 1.0
CA A:VAL249 4.8 64.6 1.0
C A:VAL249 4.8 64.1 1.0
N A:MET250 4.8 63.7 1.0

Reference:

J.Yuda, C.Will, D.C.Phillips, L.Abraham, C.Alvey, A.Avigdor, W.Buck, L.Besenhofer, E.Boghaert, D.Cheng, D.Cojocari, K.Doyle, M.Hansen, K.Huang, E.F.Johnson, A.S.Judd, R.A.Judge, J.C.Kalvass, A.Kunzer, L.T.Lam, R.Li, R.L.Martin, A.Mastracchio, M.Mitten, A.Petrich, J.Wang, J.E.Ward, H.Zhang, X.Wang, J.E.Wolff, K.M.Bell-Mcguinn, A.J.Souers. Selective Mcl-1 Inhibitor Abbv-467 Is Efficacious in Tumor Models, Associated with Cardiac Troponin Increases in Patients To Be Published.
Page generated: Wed Jul 16 03:56:22 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy