Fluorine in PDB 8f1y: Egfr Kinase in Complex with Poziotinib

All present enzymatic activity of Egfr Kinase in Complex with Poziotinib:
2.7.10.1;

The structure of Egfr Kinase in Complex with Poziotinib, PDB code: 8f1y was solved by T.S.Beyett, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	59.43 / 2.75
Space group	I 2 3
Cell size a, b, c (Å), α, β, γ (°)	145.572, 145.572, 145.572, 90, 90, 90
R / Rfree (%)	20.5 / 22.8

The structure of Egfr Kinase in Complex with Poziotinib also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Fluorine atom in the Egfr Kinase in Complex with Poziotinib (pdb code 8f1y). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Egfr Kinase in Complex with Poziotinib, PDB code: 8f1y:

Fluorine binding site 1 out of 1 in the Egfr Kinase in Complex with Poziotinib


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Egfr Kinase in Complex with Poziotinib within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:74.5 occ:1.00 FAW A:R2E1101 0.0 74.5 1.0 CAV A:R2E1101 1.3 67.0 1.0 CAT A:R2E1101 2.3 76.4 1.0 CAO A:R2E1101 2.4 72.1 1.0 N1 A:R2E1101 2.8 59.4 1.0 CL2 A:R2E1101 2.9 74.9 1.0 NAN A:R2E1101 2.9 60.5 1.0 C6 A:R2E1101 3.0 60.5 1.0 CB A:ALA743 3.1 55.5 1.0 CG2 A:THR790 3.3 49.4 1.0 O A:ALA743 3.4 65.2 1.0 CAR A:R2E1101 3.6 72.5 1.0 CAP A:R2E1101 3.6 71.5 1.0 C A:ALA743 3.7 53.1 1.0 C2 A:R2E1101 3.8 65.3 1.0 CG1 A:VAL726 3.9 52.1 1.0 CA A:ALA743 4.0 64.3 1.0 CAQ A:R2E1101 4.1 67.8 1.0 C5 A:R2E1101 4.1 59.4 1.0 N A:ILE744 4.4 64.6 1.0 CB A:LYS745 4.6 63.5 1.0 CB A:THR790 4.6 58.7 1.0 N3 A:R2E1101 4.6 59.6 1.0 CG2 A:VAL726 4.7 69.0 1.0 C A:ILE744 4.7 66.5 1.0 C4 A:R2E1101 4.8 54.6 1.0 O A:ILE744 4.9 69.0 1.0 CB A:VAL726 4.9 53.9 1.0 N A:ALA743 4.9 61.9 1.0 N A:LYS745 4.9 61.7 1.0 CL1 A:R2E1101 5.0 68.6 1.0 CA A:ILE744 5.0 61.8 1.0

T.S.Beyett, M.J.Eck. Egfr Kinase in Complex with Poziotinib To Be Published.