Fluorine in PDB 8ffv: Cryo-Em Structure of the Gr-HSP90-FKBP52 Complex

All present enzymatic activity of Cryo-Em Structure of the Gr-HSP90-FKBP52 Complex:
3.6.4.10;

The structure of Cryo-Em Structure of the Gr-HSP90-FKBP52 Complex also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of the Gr-HSP90-FKBP52 Complex (pdb code 8ffv). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of the Gr-HSP90-FKBP52 Complex, PDB code: 8ffv:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of the Gr-HSP90-FKBP52 Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Gr-HSP90-FKBP52 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:F801 b:373.1 occ:1.00 F1 C:DEX801 0.0 373.1 1.0 C9 C:DEX801 1.4 369.4 1.0 C11 C:DEX801 2.3 376.6 1.0 C8 C:DEX801 2.4 367.5 1.0 C10 C:DEX801 2.4 361.6 1.0 H14 C:DEX801 2.6 451.2 1.0 HD13 C:LEU563 2.8 464.7 1.0 HE2 C:PHE623 2.8 450.8 1.0 HB3 C:LEU563 2.8 472.6 1.0 C1 C:DEX801 2.9 367.3 1.0 C5 C:DEX801 3.0 349.1 1.0 C14 C:DEX801 3.0 376.0 1.0 C12 C:DEX801 3.0 383.4 1.0 C7 C:DEX801 3.1 362.1 1.0 HD22 C:LEU563 3.4 460.9 1.0 O2 C:DEX801 3.5 379.1 1.0 CE2 C:PHE623 3.6 375.6 1.0 C6 C:DEX801 3.6 336.0 1.0 C13 C:DEX801 3.6 380.6 1.0 C2 C:DEX801 3.7 367.6 1.0 CD1 C:LEU563 3.8 387.3 1.0 C4 C:DEX801 3.8 348.2 1.0 C19 C:DEX801 3.8 352.0 1.0 CB C:LEU563 3.8 393.8 1.0 HD2 C:PHE623 3.8 451.6 1.0 CD2 C:PHE623 4.1 376.3 1.0 C3 C:DEX801 4.1 365.4 1.0 HB2 C:LEU563 4.1 472.6 1.0 CG C:LEU563 4.2 394.3 1.0 HD12 C:LEU563 4.2 464.7 1.0 CD2 C:LEU563 4.3 384.1 1.0 O3 C:DEX801 4.4 382.8 1.0 C15 C:DEX801 4.4 377.4 1.0 HD11 C:LEU563 4.5 464.7 1.0 CZ C:PHE623 4.5 385.3 1.0 HD22 C:LEU608 4.5 417.8 1.0 HZ C:PHE623 4.6 462.4 1.0 C17 C:DEX801 4.7 387.4 1.0 C18 C:DEX801 4.7 373.9 1.0 O C:LEU563 4.8 380.3 1.0 CA C:LEU563 4.9 392.9 1.0 HD21 C:LEU563 4.9 460.9 1.0 C C:LEU563 5.0 389.1 1.0 HD23 C:LEU563 5.0 460.9 1.0

C.M.Noddings, J.L.Johnson, D.A.Agard. Cryo-Em Reveals How HSP90 and Fkbp Immunophilins Co-Regulate the Glucocorticoid Receptor Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41594-023-01128-Y