Fluorine in PDB 8ffw: Cryo-Em Structure of the Gr-HSP90-FKBP51 Complex

All present enzymatic activity of Cryo-Em Structure of the Gr-HSP90-FKBP51 Complex:
3.6.4.10; 5.2.1.8;

The structure of Cryo-Em Structure of the Gr-HSP90-FKBP51 Complex also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of the Gr-HSP90-FKBP51 Complex (pdb code 8ffw). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of the Gr-HSP90-FKBP51 Complex, PDB code: 8ffw:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of the Gr-HSP90-FKBP51 Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Gr-HSP90-FKBP51 Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:F801 b:500.3 occ:1.00 F1 C:DEX801 0.0 500.3 1.0 C9 C:DEX801 1.4 496.2 1.0 C11 C:DEX801 2.2 502.8 1.0 C8 C:DEX801 2.4 493.9 1.0 C10 C:DEX801 2.4 491.6 1.0 HE2 C:PHE623 2.7 609.8 1.0 H14 C:DEX801 2.8 599.5 1.0 C1 C:DEX801 2.9 497.9 1.0 C5 C:DEX801 3.0 481.1 1.0 C7 C:DEX801 3.1 492.6 1.0 C12 C:DEX801 3.1 506.8 1.0 C14 C:DEX801 3.1 499.6 1.0 HD22 C:LEU563 3.3 629.1 1.0 HD13 C:LEU563 3.3 631.8 1.0 O2 C:DEX801 3.5 507.7 1.0 C6 C:DEX801 3.6 477.7 1.0 CE2 C:PHE623 3.7 508.2 1.0 C13 C:DEX801 3.7 505.8 1.0 C2 C:DEX801 3.7 498.9 1.0 C4 C:DEX801 3.8 476.7 1.0 C19 C:DEX801 3.8 488.6 1.0 HB3 C:LEU563 3.8 632.9 1.0 HD22 C:LEU608 3.8 591.8 1.0 HZ C:PHE623 4.0 621.7 1.0 C3 C:DEX801 4.1 486.1 1.0 CD2 C:LEU563 4.3 524.2 1.0 CZ C:PHE623 4.3 518.1 1.0 CD1 C:LEU563 4.3 526.5 1.0 HD21 C:LEU608 4.6 591.8 1.0 C15 C:DEX801 4.6 501.2 1.0 CD2 C:LEU608 4.6 493.1 1.0 O3 C:DEX801 4.6 513.3 1.0 CD2 C:PHE623 4.7 508.8 1.0 HD23 C:LEU608 4.7 591.8 1.0 CG C:LEU563 4.7 527.5 1.0 HD2 C:PHE623 4.7 610.5 1.0 HD21 C:LEU563 4.7 629.1 1.0 CB C:LEU563 4.7 527.4 1.0 HD11 C:LEU563 4.7 631.8 1.0 C18 C:DEX801 4.7 510.2 1.0 C17 C:DEX801 4.8 511.3 1.0 HD23 C:LEU563 5.0 629.1 1.0

C.M.Noddings, J.L.Johnson, D.A.Agard. Cryo-Em Reveals How HSP90 and Fkbp Immunophilins Co-Regulate the Glucocorticoid Receptor Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41594-023-01128-Y