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Atomistry » Fluorine » PDB 8fhz-8fpe » 8fjt » |
Fluorine in PDB 8fjt: Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF362 InhibitorEnzymatic activity of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF362 Inhibitor
All present enzymatic activity of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF362 Inhibitor:
2.1.2.1; Protein crystallography data
The structure of Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF362 Inhibitor, PDB code: 8fjt
was solved by
J.M.Katinas,
C.E.Dann Iii,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF362 Inhibitor
(pdb code 8fjt). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF362 Inhibitor, PDB code: 8fjt: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 8fjtGo back to![]() ![]()
Fluorine binding site 1 out
of 2 in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF362 Inhibitor
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 8fjtGo back to![]() ![]()
Fluorine binding site 2 out
of 2 in the Human Mitochondrial Serine Hydroxymethyltransferase (SHMT2) in Complex with Plp, Glycine and AGF362 Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
M.J.Nayeen,
J.M.Katinas,
T.Magdum,
K.Shah,
J.E.Wong,
C.E.O'connor,
A.N.Fifer,
A.Wallace-Povirk,
Z.Hou,
L.H.Matherly,
C.E.Dann 3Rd,
A.Gangjee.
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria. J.Med.Chem. V. 66 11294 2023.
Page generated: Wed Jul 16 04:33:48 2025
ISSN: ISSN 0022-2623 PubMed: 37582241 DOI: 10.1021/ACS.JMEDCHEM.3C00763 |
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