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Fluorine in PDB 8fpi: Co-Structure of the Respiratory Syncytial Virus Rna-Dependent Rna Polymerase with Mrk-1

Enzymatic activity of Co-Structure of the Respiratory Syncytial Virus Rna-Dependent Rna Polymerase with Mrk-1

All present enzymatic activity of Co-Structure of the Respiratory Syncytial Virus Rna-Dependent Rna Polymerase with Mrk-1:
2.1.1.375; 2.7.7.48; 2.7.7.88;

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Co-Structure of the Respiratory Syncytial Virus Rna-Dependent Rna Polymerase with Mrk-1 (pdb code 8fpi). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Co-Structure of the Respiratory Syncytial Virus Rna-Dependent Rna Polymerase with Mrk-1, PDB code: 8fpi:

Fluorine binding site 1 out of 1 in 8fpi

Go back to Fluorine Binding Sites List in 8fpi
Fluorine binding site 1 out of 1 in the Co-Structure of the Respiratory Syncytial Virus Rna-Dependent Rna Polymerase with Mrk-1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Co-Structure of the Respiratory Syncytial Virus Rna-Dependent Rna Polymerase with Mrk-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F9001

b:53.4
occ:1.00
F A:Y6L9001 0.0 53.4 1.0
C9 A:Y6L9001 1.4 53.4 1.0
C8 A:Y6L9001 2.3 53.4 1.0
C10 A:Y6L9001 2.3 53.4 1.0
H10 A:Y6L9001 2.6 53.4 1.0
H11 A:Y6L9001 2.6 53.4 1.0
HD11 A:ILE1241 2.7 53.7 1.0
HD13 A:ILE1241 2.7 53.7 1.0
HG22 A:THR1365 2.7 54.9 1.0
HG21 A:ILE1368 3.0 56.6 1.0
CD1 A:ILE1241 3.1 53.7 1.0
HG12 A:ILE1241 3.1 53.7 1.0
HG22 A:ILE1368 3.2 56.6 1.0
HB A:ILE1368 3.4 56.6 1.0
CG2 A:ILE1368 3.5 56.6 1.0
HD1 A:PHE1385 3.5 52.2 1.0
C7 A:Y6L9001 3.6 53.4 1.0
C11 A:Y6L9001 3.6 53.4 1.0
CG1 A:ILE1241 3.6 53.7 1.0
CG2 A:THR1365 3.7 54.9 1.0
HE1 A:PHE1385 3.7 52.2 1.0
HB A:THR1365 3.8 54.9 1.0
CB A:ILE1368 3.9 56.6 1.0
HD12 A:ILE1241 4.0 53.7 1.0
HG21 A:THR1365 4.0 54.9 1.0
HG13 A:ILE1241 4.0 53.7 1.0
HB2 A:CYS1388 4.0 51.0 1.0
C6 A:Y6L9001 4.1 53.4 1.0
HG13 A:ILE1368 4.1 56.6 1.0
CD1 A:PHE1385 4.2 52.2 1.0
CE1 A:PHE1385 4.2 52.2 1.0
CB A:THR1365 4.2 54.9 1.0
HB3 A:CYS1388 4.3 51.0 1.0
HG23 A:THR1365 4.3 54.9 1.0
HG23 A:ILE1368 4.4 56.6 1.0
SG A:CYS1388 4.4 51.0 1.0
HD12 A:LEU1372 4.4 55.5 1.0
CB A:CYS1388 4.4 51.0 1.0
HA A:THR1365 4.5 54.9 1.0
H9 A:Y6L9001 4.5 53.4 1.0
H12 A:Y6L9001 4.5 53.4 1.0
HD11 A:LEU1372 4.5 55.5 1.0
HG23 A:ILE1241 4.6 53.7 1.0
CG1 A:ILE1368 4.6 56.6 1.0
HE1 A:MET1228 4.6 52.1 1.0
HA A:PHE1385 4.8 52.2 1.0
O A:THR1365 4.8 54.9 1.0
HD13 A:ILE1389 4.9 50.9 1.0
CA A:THR1365 4.9 54.9 1.0
CD1 A:LEU1372 4.9 55.5 1.0
CB A:ILE1241 4.9 53.7 1.0

Reference:

V.A.Kleiner, T.O.Fischmann, J.A.Howe, D.C.Beshore, M.J.Eddins, Y.Hou, T.Mayhood, D.Klein, D.D.Nahas, B.J.Lucas, D.Ma, K.Getty, R.Fearns. Conserved Allosteric Inhibitory Site on the Respiratory Syncytial Virus and Human Metapneumovirus Rna-Dependent Rna Polymerases Commun Biol 2023.
ISSN: ESSN 2399-3642
Page generated: Wed Jul 16 04:43:56 2025

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