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Fluorine in PDB 8fpj: Co-Structure of the Human Metapneunomovirus Rna-Dependent Rna Polymerase with Mrk-1

Enzymatic activity of Co-Structure of the Human Metapneunomovirus Rna-Dependent Rna Polymerase with Mrk-1

All present enzymatic activity of Co-Structure of the Human Metapneunomovirus Rna-Dependent Rna Polymerase with Mrk-1:
2.1.1.375; 2.7.7.48; 2.7.7.88;

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Co-Structure of the Human Metapneunomovirus Rna-Dependent Rna Polymerase with Mrk-1 (pdb code 8fpj). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Co-Structure of the Human Metapneunomovirus Rna-Dependent Rna Polymerase with Mrk-1, PDB code: 8fpj:

Fluorine binding site 1 out of 1 in 8fpj

Go back to Fluorine Binding Sites List in 8fpj
Fluorine binding site 1 out of 1 in the Co-Structure of the Human Metapneunomovirus Rna-Dependent Rna Polymerase with Mrk-1


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Co-Structure of the Human Metapneunomovirus Rna-Dependent Rna Polymerase with Mrk-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F9901

b:38.5
occ:1.00
F A:Y6L9901 0.0 38.5 1.0
C9 A:Y6L9901 1.4 38.5 1.0
C8 A:Y6L9901 2.3 38.5 1.0
C10 A:Y6L9901 2.3 38.5 1.0
H10 A:Y6L9901 2.6 38.5 0.0
H11 A:Y6L9901 2.6 38.5 0.0
HD13 A:ILE1293 2.6 41.5 0.0
HG21 A:ILE1293 3.0 41.5 0.0
HD12 A:ILE1166 3.1 39.4 0.0
HD1 A:PHE1310 3.2 36.9 0.0
HB A:ILE1166 3.6 39.4 0.0
CD1 A:ILE1293 3.6 41.5 1.0
C7 A:Y6L9901 3.6 38.5 1.0
C11 A:Y6L9901 3.6 38.5 1.0
HG23 A:ILE1293 3.7 41.5 0.0
HB3 A:ALA1313 3.7 34.8 0.0
CG2 A:ILE1293 3.8 41.5 1.0
HD13 A:ILE1166 4.0 39.4 0.0
CD1 A:ILE1166 4.0 39.4 1.0
HD11 A:ILE1293 4.0 41.5 0.0
CD1 A:PHE1310 4.0 36.9 1.0
HD12 A:ILE1293 4.1 41.5 0.0
HB1 A:ALA1313 4.1 34.8 0.0
C6 A:Y6L9901 4.1 38.5 1.0
HG21 A:ILE1166 4.1 39.4 0.0
HG21 A:THR1290 4.1 40.7 0.0
HB A:THR1290 4.1 40.7 0.0
HA A:PHE1310 4.2 36.9 0.0
HG12 A:ILE1293 4.2 41.5 0.0
CB A:ALA1313 4.3 34.8 1.0
CB A:ILE1166 4.4 39.4 1.0
CG1 A:ILE1293 4.4 41.5 1.0
HE1 A:PHE1310 4.4 36.9 0.0
HE1 A:MET1153 4.4 38.8 0.0
HG22 A:ILE1293 4.4 41.5 0.0
HB2 A:ALA1313 4.4 34.8 0.0
H9 A:Y6L9901 4.5 38.5 0.0
H12 A:Y6L9901 4.5 38.5 0.0
HB2 A:PHE1310 4.5 36.9 0.0
HG22 A:ILE1166 4.6 39.4 0.0
CG2 A:ILE1166 4.6 39.4 1.0
HD11 A:ILE1166 4.6 39.4 0.0
CB A:ILE1293 4.6 41.5 1.0
CE1 A:PHE1310 4.7 36.9 1.0
HD23 A:LEU1308 4.7 37.4 0.0
CG1 A:ILE1166 4.8 39.4 1.0
CG2 A:THR1290 4.8 40.7 1.0
HB A:ILE1293 4.9 41.5 0.0
HE3 A:MET1153 4.9 38.8 0.0
CB A:THR1290 4.9 40.7 1.0
HD11 A:LEU1297 4.9 42.1 0.0
HD21 A:LEU1308 5.0 37.4 0.0
CA A:PHE1310 5.0 36.9 1.0
HG13 A:ILE1314 5.0 35.3 0.0

Reference:

V.A.Kleiner, T.O.Fischmann, J.A.Howe, D.C.Beshore, M.J.Eddins, Y.Hou, T.Mayhood, D.Klein, D.D.Nahas, B.J.Lucas, D.Ma, K.Getty, R.Fearns. Conserved Allosteric Inhibitory Site on the Respiratory Syncytial Virus and Human Metapneumovirus Rna-Dependent Rna Polymerases Commun Biol 2023.
ISSN: ESSN 2399-3642
Page generated: Wed Jul 16 04:43:56 2025

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