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Fluorine in PDB 8fxa: Bromodomain of Cbp Liganded with ICBP4

Enzymatic activity of Bromodomain of Cbp Liganded with ICBP4

All present enzymatic activity of Bromodomain of Cbp Liganded with ICBP4:
2.3.1.48;

Protein crystallography data

The structure of Bromodomain of Cbp Liganded with ICBP4, PDB code: 8fxa was solved by E.Schonbrunn, M.Bikowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.59 / 1.65
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 33.71, 81.83, 48, 90, 109.51, 90
R / Rfree (%) 14.6 / 18

Fluorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Bromodomain of Cbp Liganded with ICBP4 (pdb code 8fxa). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Bromodomain of Cbp Liganded with ICBP4, PDB code: 8fxa:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in 8fxa

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Fluorine binding site 1 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1204

b:25.8
occ:1.00
 F36 A:YJY1204 0.0 25.8 1.0
C35 A:YJY1204 1.4 24.6 1.0
F38 A:YJY1204 2.2 26.8 1.0
F37 A:YJY1204 2.2 28.4 1.0
C34 A:YJY1204 2.3 15.1 1.0
C39 A:YJY1204 3.0 18.2 1.0
CB A:LEU1109 3.2 9.8 1.0
C33 A:YJY1204 3.3 18.3 1.0
C27 A:YJY1204 3.4 12.7 1.0
C28 A:YJY1204 3.4 13.5 1.0
C A:LEU1109 3.8 7.5 1.0
N A:PRO1110 4.0 6.6 1.0
O A:LEU1109 4.0 9.7 1.0
CA A:LEU1109 4.1 9.9 1.0
CD1 A:LEU1109 4.2 17.5 1.0
O A:HOH1388 4.2 22.1 1.0
C40 A:YJY1204 4.3 10.4 1.0
CG A:LEU1109 4.3 14.8 1.0
CD A:PRO1110 4.4 7.0 1.0
CA A:PRO1110 4.4 8.8 1.0
C32 A:YJY1204 4.5 14.2 1.0
C23 A:YJY1204 4.6 10.1 1.0
C26 A:YJY1204 4.8 22.4 1.0
CB A:PRO1110 4.8 9.3 1.0
C45 A:YJY1204 4.9 14.3 1.0

Fluorine binding site 2 out of 12 in 8fxa

Go back to Fluorine Binding Sites List in 8fxa
Fluorine binding site 2 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1204

b:28.4
occ:1.00
 F37 A:YJY1204 0.0 28.4 1.0
C35 A:YJY1204 1.4 24.6 1.0
F36 A:YJY1204 2.2 25.8 1.0
F38 A:YJY1204 2.2 26.8 1.0
C34 A:YJY1204 2.4 15.1 1.0
C39 A:YJY1204 2.9 18.2 1.0
C33 A:YJY1204 3.5 18.3 1.0
CD1 A:LEU1109 3.5 17.5 1.0
CB A:LEU1109 3.9 9.8 1.0
C40 A:YJY1204 4.3 10.4 1.0
CG A:LEU1109 4.3 14.8 1.0
C32 A:YJY1204 4.7 14.2 1.0

Fluorine binding site 3 out of 12 in 8fxa

Go back to Fluorine Binding Sites List in 8fxa
Fluorine binding site 3 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1204

b:26.8
occ:1.00
 F38 A:YJY1204 0.0 26.8 1.0
C35 A:YJY1204 1.4 24.6 1.0
F36 A:YJY1204 2.2 25.8 1.0
F37 A:YJY1204 2.2 28.4 1.0
C34 A:YJY1204 2.4 15.1 1.0
C33 A:YJY1204 2.7 18.3 1.0
O A:HOH1457 3.5 30.3 1.0
O A:HOH1428 3.6 18.2 1.0
C39 A:YJY1204 3.7 18.2 1.0
C27 A:YJY1204 3.9 12.7 1.0
C32 A:YJY1204 4.1 14.2 1.0
C28 A:YJY1204 4.1 13.5 1.0
C26 A:YJY1204 4.7 22.4 1.0
C23 A:YJY1204 4.7 10.1 1.0
C40 A:YJY1204 4.8 10.4 1.0
N31 A:YJY1204 4.9 14.1 1.0
C45 A:YJY1204 5.0 14.3 1.0

Fluorine binding site 4 out of 12 in 8fxa

Go back to Fluorine Binding Sites List in 8fxa
Fluorine binding site 4 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1204

b:19.9
occ:1.00
 F42 A:YJY1204 0.0 19.9 1.0
C41 A:YJY1204 1.3 14.9 1.0
F43 A:YJY1204 2.2 18.5 1.0
F44 A:YJY1204 2.2 17.1 1.0
C40 A:YJY1204 2.3 10.4 1.0
C39 A:YJY1204 2.9 18.2 1.0
CG A:PRO1110 3.0 9.7 1.0
C45 A:YJY1204 3.4 14.3 1.0
CD2 A:PHE1177 3.5 6.8 1.0
CE2 A:PHE1177 3.5 7.6 1.0
CD A:PRO1110 3.5 7.0 1.0
CB A:PRO1110 3.6 9.3 1.0
CG2 A:VAL1174 3.9 8.5 1.0
C34 A:YJY1204 4.2 15.1 1.0
CB A:ARG1173 4.2 7.5 1.0
N A:VAL1174 4.4 6.6 1.0
C32 A:YJY1204 4.6 14.2 1.0
CA A:VAL1174 4.6 6.3 1.0
N A:PRO1110 4.6 6.6 1.0
C A:ARG1173 4.7 7.9 1.0
CZ A:PHE1177 4.7 7.4 1.0
CG A:PHE1177 4.7 6.6 1.0
CA A:PRO1110 4.8 8.8 1.0
O A:HOH1400 4.8 11.3 1.0
C33 A:YJY1204 4.9 18.3 1.0
CB A:VAL1174 4.9 6.9 1.0
NH1 A:ARG1173 4.9 11.2 1.0
CZ A:ARG1173 4.9 10.2 1.0
NE A:ARG1173 5.0 8.4 1.0

Fluorine binding site 5 out of 12 in 8fxa

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Fluorine binding site 5 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1204

b:18.5
occ:1.00
 F43 A:YJY1204 0.0 18.5 1.0
C41 A:YJY1204 1.4 14.9 1.0
F42 A:YJY1204 2.2 19.9 1.0
F44 A:YJY1204 2.2 17.1 1.0
C40 A:YJY1204 2.4 10.4 1.0
C45 A:YJY1204 2.7 14.3 1.0
O A:HOH1400 3.2 11.3 1.0
CZ A:ARG1173 3.2 10.2 1.0
NE A:ARG1173 3.3 8.4 1.0
O A:HOH1414 3.3 33.0 1.0
CB A:ARG1173 3.4 7.5 1.0
NH2 A:ARG1173 3.5 9.4 1.0
C39 A:YJY1204 3.7 18.2 1.0
NH1 A:ARG1173 3.7 11.2 1.0
CG2 A:VAL1174 3.7 8.5 1.0
CD A:ARG1173 3.9 9.0 1.0
N A:VAL1174 4.0 6.6 1.0
C32 A:YJY1204 4.0 14.2 1.0
CG A:ARG1173 4.2 8.0 1.0
CA A:ARG1173 4.4 7.2 1.0
C A:ARG1173 4.4 7.9 1.0
CA A:VAL1174 4.7 6.3 1.0
CB A:VAL1174 4.8 6.9 1.0
C34 A:YJY1204 4.8 15.1 1.0
CE2 A:PHE1177 4.8 7.6 1.0
N08 A:YJY1204 4.9 11.9 1.0
CG A:PRO1110 4.9 9.7 1.0
N31 A:YJY1204 4.9 14.1 1.0
C33 A:YJY1204 4.9 18.3 1.0
N A:ARG1173 4.9 7.3 1.0
O01 A:YJY1204 4.9 14.9 1.0

Fluorine binding site 6 out of 12 in 8fxa

Go back to Fluorine Binding Sites List in 8fxa
Fluorine binding site 6 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1204

b:17.1
occ:1.00
 F44 A:YJY1204 0.0 17.1 1.0
C41 A:YJY1204 1.4 14.9 1.0
F42 A:YJY1204 2.2 19.9 1.0
F43 A:YJY1204 2.2 18.5 1.0
C40 A:YJY1204 2.3 10.4 1.0
C39 A:YJY1204 3.0 18.2 1.0
NH1 A:ARG1173 3.1 11.2 1.0
CD A:ARG1173 3.2 9.0 1.0
CE2 A:PHE1177 3.3 7.6 1.0
C45 A:YJY1204 3.3 14.3 1.0
CZ A:ARG1173 3.3 10.2 1.0
NE A:ARG1173 3.4 8.4 1.0
CB A:ARG1173 3.4 7.5 1.0
O A:HOH1383 3.7 12.8 1.0
CG A:ARG1173 3.8 8.0 1.0
CZ A:PHE1177 4.0 7.4 1.0
CD2 A:PHE1177 4.0 6.8 1.0
NH2 A:ARG1173 4.2 9.4 1.0
C34 A:YJY1204 4.2 15.1 1.0
C32 A:YJY1204 4.5 14.2 1.0
CA A:ARG1173 4.8 7.2 1.0
C33 A:YJY1204 4.8 18.3 1.0
C A:ARG1173 5.0 7.9 1.0

Fluorine binding site 7 out of 12 in 8fxa

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Fluorine binding site 7 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1302

b:20.4
occ:1.00
 F36 B:YJY1302 0.0 20.4 1.0
C35 B:YJY1302 1.4 15.2 1.0
F37 B:YJY1302 2.2 18.5 1.0
F38 B:YJY1302 2.2 17.9 1.0
C34 B:YJY1302 2.3 11.1 1.0
C39 B:YJY1302 2.9 13.5 1.0
CG B:PRO1110 3.1 12.5 1.0
C33 B:YJY1302 3.4 13.7 1.0
CD2 B:PHE1177 3.6 7.5 1.0
CB B:PRO1110 3.6 12.0 1.0
CE2 B:PHE1177 3.6 7.0 1.0
CD B:PRO1110 3.6 7.1 1.0
CG2 B:VAL1174 3.6 8.8 1.0
O B:HOH1476 3.9 15.3 1.0
C40 B:YJY1302 4.2 17.1 1.0
CB B:ARG1173 4.3 5.5 1.0
N B:VAL1174 4.3 5.8 1.0
CA B:VAL1174 4.5 5.4 1.0
C32 B:YJY1302 4.5 13.2 1.0
C B:ARG1173 4.7 5.4 1.0
N B:PRO1110 4.7 7.8 1.0
CB B:VAL1174 4.7 6.2 1.0
CG B:PHE1177 4.8 5.1 1.0
O A:HOH1331 4.8 9.8 1.0
CA B:PRO1110 4.8 8.4 1.0
CZ B:PHE1177 4.8 6.3 1.0
C45 B:YJY1302 4.9 17.7 1.0
CZ B:ARG1173 5.0 9.6 1.0

Fluorine binding site 8 out of 12 in 8fxa

Go back to Fluorine Binding Sites List in 8fxa
Fluorine binding site 8 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1302

b:18.5
occ:1.00
 F37 B:YJY1302 0.0 18.5 1.0
C35 B:YJY1302 1.4 15.2 1.0
F36 B:YJY1302 2.2 20.4 1.0
F38 B:YJY1302 2.2 17.9 1.0
C34 B:YJY1302 2.4 11.1 1.0
C33 B:YJY1302 2.7 13.7 1.0
O A:HOH1331 3.1 9.8 1.0
CZ B:ARG1173 3.2 9.6 1.0
NE B:ARG1173 3.3 7.8 1.0
NH2 B:ARG1173 3.4 8.6 1.0
CB B:ARG1173 3.4 5.5 1.0
CG2 B:VAL1174 3.6 8.8 1.0
C39 B:YJY1302 3.7 13.5 1.0
NH1 B:ARG1173 3.8 10.1 1.0
CD B:ARG1173 3.9 7.8 1.0
N B:VAL1174 4.0 5.8 1.0
C32 B:YJY1302 4.0 13.2 1.0
OE1 A:GLU1186 4.2 9.2 1.0
CG B:ARG1173 4.3 6.3 1.0
C B:ARG1173 4.4 5.4 1.0
CA B:ARG1173 4.4 5.6 1.0
CA B:VAL1174 4.6 5.4 1.0
CB B:VAL1174 4.7 6.2 1.0
C40 B:YJY1302 4.8 17.1 1.0
CE2 B:PHE1177 4.8 7.0 1.0
N B:ARG1173 4.9 5.8 1.0
N08 B:YJY1302 4.9 13.0 1.0
N31 B:YJY1302 4.9 12.0 1.0
C45 B:YJY1302 4.9 17.7 1.0
O01 B:YJY1302 4.9 18.5 1.0
OE2 A:GLU1186 4.9 15.7 1.0
O B:HOH1487 5.0 23.7 1.0
CD A:GLU1186 5.0 9.6 1.0

Fluorine binding site 9 out of 12 in 8fxa

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Fluorine binding site 9 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1302

b:17.9
occ:1.00
 F38 B:YJY1302 0.0 17.9 1.0
C35 B:YJY1302 1.4 15.2 1.0
F36 B:YJY1302 2.2 20.4 1.0
F37 B:YJY1302 2.2 18.5 1.0
C34 B:YJY1302 2.3 11.1 1.0
C39 B:YJY1302 2.9 13.5 1.0
NH1 B:ARG1173 3.1 10.1 1.0
CE2 B:PHE1177 3.2 7.0 1.0
CD B:ARG1173 3.2 7.8 1.0
CZ B:ARG1173 3.3 9.6 1.0
NE B:ARG1173 3.3 7.8 1.0
CB B:ARG1173 3.3 5.5 1.0
C33 B:YJY1302 3.4 13.7 1.0
O A:HOH1362 3.7 12.7 1.0
O B:HOH1476 3.8 15.3 1.0
CG B:ARG1173 3.9 6.3 1.0
CZ B:PHE1177 3.9 6.3 1.0
CD2 B:PHE1177 4.0 7.5 1.0
NH2 B:ARG1173 4.2 8.6 1.0
C40 B:YJY1302 4.2 17.1 1.0
O A:HOH1393 4.4 12.4 1.0
C32 B:YJY1302 4.5 13.2 1.0
CA B:ARG1173 4.7 5.6 1.0
C45 B:YJY1302 4.9 17.7 1.0
C B:ARG1173 4.9 5.4 1.0

Fluorine binding site 10 out of 12 in 8fxa

Go back to Fluorine Binding Sites List in 8fxa
Fluorine binding site 10 out of 12 in the Bromodomain of Cbp Liganded with ICBP4


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Bromodomain of Cbp Liganded with ICBP4 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1302

b:32.2
occ:1.00
 F42 B:YJY1302 0.0 32.2 1.0
C41 B:YJY1302 1.4 26.6 1.0
F43 B:YJY1302 2.2 28.3 1.0
F44 B:YJY1302 2.2 33.6 1.0
C40 B:YJY1302 2.4 17.1 1.0
C45 B:YJY1302 2.7 17.7 1.0
O B:HOH1530 3.6 22.7 1.0
C39 B:YJY1302 3.7 13.5 1.0
C24 B:YJY1302 3.8 21.0 1.0
C25 B:YJY1302 3.9 14.5 1.0
C32 B:YJY1302 4.0 13.2 1.0
O A:HOH1455 4.3 22.3 1.0
O B:HOH1516 4.4 31.2 1.0
C34 B:YJY1302 4.8 11.1 1.0
N31 B:YJY1302 4.9 12.0 1.0
C33 B:YJY1302 4.9 13.7 1.0

Reference:

E.Schonbrunn, M.Bikowitz. Group 3 Medulloblastoma Transcriptional Networks Are Sensitive to EP300/Cbp Bromodomain Inhibition To Be Published.
Page generated: Wed Jul 16 04:50:33 2025

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