Atomistry » Fluorine » PDB 8jp0-8kct » 8jvi
Atomistry »
  Fluorine »
    PDB 8jp0-8kct »
      8jvi »

Fluorine in PDB 8jvi: Structure of Human TRPV4 with Antagonist A2

Fluorine Binding Sites:

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Structure of Human TRPV4 with Antagonist A2 (pdb code 8jvi). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Structure of Human TRPV4 with Antagonist A2, PDB code: 8jvi:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 1 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1201

b:40.8
occ:1.00
 F03 B:F9M1201 0.0 40.8 1.0
C31 B:F9M1201 1.4 40.8 1.0
F04 B:F9M1201 2.2 40.8 1.0
F05 B:F9M1201 2.2 40.8 1.0
C28 B:F9M1201 2.4 40.8 1.0
C26 B:F9M1201 3.2 40.8 1.0
C27 B:F9M1201 3.4 40.8 1.0
O B:LYS465 3.9 33.8 1.0
CG2 B:VAL469 4.0 42.5 1.0
N09 B:F9M1201 4.5 40.8 1.0
CG1 B:VAL469 4.6 42.5 1.0
O B:ARG464 4.6 32.2 1.0
N10 B:F9M1201 4.6 40.8 1.0
CB B:VAL469 4.8 42.5 1.0
C B:LYS465 4.9 33.8 1.0

Fluorine binding site 2 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 2 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1201

b:40.8
occ:1.00
 F04 B:F9M1201 0.0 40.8 1.0
C31 B:F9M1201 1.4 40.8 1.0
F03 B:F9M1201 2.2 40.8 1.0
F05 B:F9M1201 2.2 40.8 1.0
C28 B:F9M1201 2.4 40.8 1.0
C27 B:F9M1201 2.7 40.8 1.0
C26 B:F9M1201 3.7 40.8 1.0
N10 B:F9M1201 4.2 40.8 1.0
N09 B:F9M1201 4.9 40.8 1.0
O B:LYS465 5.0 33.8 1.0

Fluorine binding site 3 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 3 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1201

b:40.8
occ:1.00
 F05 B:F9M1201 0.0 40.8 1.0
C31 B:F9M1201 1.4 40.8 1.0
F04 B:F9M1201 2.2 40.8 1.0
F03 B:F9M1201 2.2 40.8 1.0
C28 B:F9M1201 2.4 40.8 1.0
C26 B:F9M1201 2.9 40.8 1.0
C27 B:F9M1201 3.6 40.8 1.0
N09 B:F9M1201 4.3 40.8 1.0
N10 B:F9M1201 4.8 40.8 1.0
CG1 B:VAL469 4.9 42.5 1.0

Fluorine binding site 4 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 4 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F1201

b:22.0
occ:1.00
 F03 C:F9M1201 0.0 22.0 1.0
C31 C:F9M1201 1.4 22.0 1.0
F05 C:F9M1201 2.2 22.0 1.0
F04 C:F9M1201 2.2 22.0 1.0
C28 C:F9M1201 2.4 22.0 1.0
C26 C:F9M1201 3.2 22.0 1.0
C27 C:F9M1201 3.4 22.0 1.0
N09 C:F9M1201 4.5 22.0 1.0
N10 C:F9M1201 4.6 22.0 1.0

Fluorine binding site 5 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 5 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F1201

b:22.0
occ:1.00
 F04 C:F9M1201 0.0 22.0 1.0
C31 C:F9M1201 1.4 22.0 1.0
F05 C:F9M1201 2.2 22.0 1.0
F03 C:F9M1201 2.2 22.0 1.0
C28 C:F9M1201 2.4 22.0 1.0
C26 C:F9M1201 2.9 22.0 1.0
C27 C:F9M1201 3.6 22.0 1.0
CG2 C:VAL469 3.9 21.2 1.0
O C:LYS465 4.1 20.9 1.0
N09 C:F9M1201 4.3 22.0 1.0
O C:ARG464 4.7 20.3 1.0
CB C:VAL469 4.7 21.2 1.0
N10 C:F9M1201 4.8 22.0 1.0
CG1 C:VAL469 5.0 21.2 1.0

Fluorine binding site 6 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 6 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:F1201

b:22.0
occ:1.00
 F05 C:F9M1201 0.0 22.0 1.0
C31 C:F9M1201 1.4 22.0 1.0
F04 C:F9M1201 2.2 22.0 1.0
F03 C:F9M1201 2.2 22.0 1.0
C28 C:F9M1201 2.4 22.0 1.0
C27 C:F9M1201 2.7 22.0 1.0
C26 C:F9M1201 3.7 22.0 1.0
O C:LYS465 4.1 20.9 1.0
N10 C:F9M1201 4.2 22.0 1.0
N09 C:F9M1201 4.9 22.0 1.0

Fluorine binding site 7 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 7 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1201

b:40.8
occ:1.00
 F03 D:F9M1201 0.0 40.8 1.0
C31 D:F9M1201 1.4 40.8 1.0
F04 D:F9M1201 2.2 40.8 1.0
F05 D:F9M1201 2.2 40.8 1.0
C28 D:F9M1201 2.4 40.8 1.0
C26 D:F9M1201 3.2 40.8 1.0
C27 D:F9M1201 3.4 40.8 1.0
O D:LYS465 3.9 33.8 1.0
CG2 D:VAL469 4.0 42.5 1.0
N09 D:F9M1201 4.5 40.8 1.0
CG1 D:VAL469 4.6 42.5 1.0
O D:ARG464 4.6 32.2 1.0
N10 D:F9M1201 4.6 40.8 1.0
CB D:VAL469 4.8 42.5 1.0
C D:LYS465 4.9 33.8 1.0

Fluorine binding site 8 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 8 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1201

b:40.8
occ:1.00
 F04 D:F9M1201 0.0 40.8 1.0
C31 D:F9M1201 1.4 40.8 1.0
F03 D:F9M1201 2.2 40.8 1.0
F05 D:F9M1201 2.2 40.8 1.0
C28 D:F9M1201 2.4 40.8 1.0
C27 D:F9M1201 2.7 40.8 1.0
C26 D:F9M1201 3.7 40.8 1.0
N10 D:F9M1201 4.2 40.8 1.0
N09 D:F9M1201 4.9 40.8 1.0
O D:LYS465 5.0 33.8 1.0

Fluorine binding site 9 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 9 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F1201

b:40.8
occ:1.00
 F05 D:F9M1201 0.0 40.8 1.0
C31 D:F9M1201 1.4 40.8 1.0
F04 D:F9M1201 2.2 40.8 1.0
F03 D:F9M1201 2.2 40.8 1.0
C28 D:F9M1201 2.4 40.8 1.0
C26 D:F9M1201 2.9 40.8 1.0
C27 D:F9M1201 3.6 40.8 1.0
N09 D:F9M1201 4.3 40.8 1.0
N10 D:F9M1201 4.8 40.8 1.0
CG1 D:VAL469 4.9 42.5 1.0

Fluorine binding site 10 out of 12 in 8jvi

Go back to Fluorine Binding Sites List in 8jvi
Fluorine binding site 10 out of 12 in the Structure of Human TRPV4 with Antagonist A2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Structure of Human TRPV4 with Antagonist A2 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1201

b:22.0
occ:1.00
 F03 A:F9M1201 0.0 22.0 1.0
C31 A:F9M1201 1.4 22.0 1.0
F05 A:F9M1201 2.2 22.0 1.0
F04 A:F9M1201 2.2 22.0 1.0
C28 A:F9M1201 2.4 22.0 1.0
C26 A:F9M1201 3.2 22.0 1.0
C27 A:F9M1201 3.4 22.0 1.0
N09 A:F9M1201 4.5 22.0 1.0
N10 A:F9M1201 4.6 22.0 1.0

Reference:

J.Fan, C.Guo, D.Liao, H.Ke, J.Lei, W.Xie, Y.Tang, M.Tominaga, Z.Huang, X.Lei. Structural Pharmacology of TRPV4 Antagonists. Adv Sci 01583 2024.
ISSN: ESSN 2198-3844
PubMed: 38659239
DOI: 10.1002/ADVS.202401583
Page generated: Wed Jul 16 05:52:27 2025

Last articles

Fe in 4NVJ
Fe in 4NVK
Fe in 4NVI
Fe in 4NVH
Fe in 4NVG
Fe in 4NVF
Fe in 4NVE
Fe in 4NVD
Fe in 4NVC
Fe in 4NSE
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy