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Fluorine in PDB 8pbg: Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate
Enzymatic activity of Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate
All present enzymatic activity of Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate:
2.1.3.2; 3.5.2.3; 6.3.5.5;
2.1.3.2; 3.5.2.3; 6.3.5.5;
Protein crystallography data
The structure of Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate, PDB code: 8pbg
was solved by
F.Del Cano-Ochoa,
S.Ramon-Maiques,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 44.53 / 1.46 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 82.06, 159.031, 61.933, 90, 90, 90 |
| R / Rfree (%) | 12.3 / 15 |
Other elements in 8pbg:
The structure of Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate
(pdb code 8pbg). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate, PDB code: 8pbg:
In total only one binding site of Fluorine was determined in the Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate, PDB code: 8pbg:
Fluorine binding site 1 out of 1 in 8pbg
Go back to
Fluorine Binding Sites List in 8pbg
Fluorine binding site 1 out
of 1 in the Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Mutant K1556T of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoroorotate within 5.0Å range:
|
Reference:
F.Del Cano-Ochoa,
B.G.Ng,
A.Rubio-Del-Campo,
S.Mahajan,
M.P.Wilson,
M.Vilar,
D.Rymen,
P.Sanchez-Pintos,
J.Kenny,
M.Ley Martos,
T.Campos,
S.B.Wortmann,
H.H.Freeze,
S.Ramon-Maiques.
Beyond Genetics: Deciphering the Impact of Missense Variants in Cad Deficiency. J Inherit Metab Dis 2023.
ISSN: ISSN 1573-2665
PubMed: 37540500
DOI: 10.1002/JIMD.12667
Page generated: Wed Jul 16 06:29:00 2025
ISSN: ISSN 1573-2665
PubMed: 37540500
DOI: 10.1002/JIMD.12667
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