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Fluorine in PDB 8pbk: Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate
Enzymatic activity of Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate
All present enzymatic activity of Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate:
2.1.3.2; 3.5.2.3; 6.3.5.5;
2.1.3.2; 3.5.2.3; 6.3.5.5;
Protein crystallography data
The structure of Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate, PDB code: 8pbk
was solved by
F.Del Cano-Ochoa,
S.Ramon-Maiques,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 44.36 / 1.69 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 82.158, 158.123, 61.939, 90, 90, 90 |
| R / Rfree (%) | 13.9 / 18.3 |
Other elements in 8pbk:
The structure of Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate
(pdb code 8pbk). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate, PDB code: 8pbk:
In total only one binding site of Fluorine was determined in the Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate, PDB code: 8pbk:
Fluorine binding site 1 out of 1 in 8pbk
Go back to
Fluorine Binding Sites List in 8pbk
Fluorine binding site 1 out
of 1 in the Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Mutant R1722W of the Dihydroorotase Domain of Human Cad Protein Bound to the Inhibitor Fluoorotate within 5.0Å range:
|
Reference:
F.Del Cano-Ochoa,
B.G.Ng,
A.Rubio-Del-Campo,
S.Mahajan,
M.P.Wilson,
M.Vilar,
D.Rymen,
P.Sanchez-Pintos,
J.Kenny,
M.Ley Martos,
T.Campos,
S.B.Wortmann,
H.H.Freeze,
S.Ramon-Maiques.
Beyond Genetics: Deciphering the Impact of Missense Variants in Cad Deficiency. J Inherit Metab Dis 2023.
ISSN: ISSN 1573-2665
PubMed: 37540500
DOI: 10.1002/JIMD.12667
Page generated: Wed Jul 16 06:29:00 2025
ISSN: ISSN 1573-2665
PubMed: 37540500
DOI: 10.1002/JIMD.12667
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