Atomistry » Fluorine » PDB 8q35-8qxs » 8qm7
Atomistry »
  Fluorine »
    PDB 8q35-8qxs »
      8qm7 »

Fluorine in PDB 8qm7: Potential Drug Binding Sites For Translation Initiation Factor EIF4E

Protein crystallography data

The structure of Potential Drug Binding Sites For Translation Initiation Factor EIF4E, PDB code: 8qm7 was solved by A.Cleasby, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 64.12 / 2.19
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.157, 69.122, 64.435, 90, 95.67, 90
R / Rfree (%) 19.2 / 24

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Potential Drug Binding Sites For Translation Initiation Factor EIF4E (pdb code 8qm7). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Potential Drug Binding Sites For Translation Initiation Factor EIF4E, PDB code: 8qm7:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 8qm7

Go back to Fluorine Binding Sites List in 8qm7
Fluorine binding site 1 out of 2 in the Potential Drug Binding Sites For Translation Initiation Factor EIF4E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Potential Drug Binding Sites For Translation Initiation Factor EIF4E within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F304

b:25.7
occ:0.94
F25 A:W5K304 0.0 25.7 0.9
C24 A:W5K304 1.3 27.4 0.9
C23 A:W5K304 2.3 27.6 0.9
C19 A:W5K304 2.4 28.2 0.9
H51 A:W5K304 2.5 27.6 0.9
H40 A:W5K304 2.7 30.6 0.9
C12 A:W5K304 2.8 29.5 0.9
C11 A:W5K304 3.0 30.6 0.9
CD1 A:LEU45 3.2 29.2 1.0
CZ2 A:TRP130 3.3 18.8 1.0
NE1 A:TRP130 3.3 20.0 1.0
C22 A:W5K304 3.6 28.0 0.9
C20 A:W5K304 3.6 28.2 0.9
CE2 A:TRP130 3.6 19.3 1.0
CD2 A:LEU134 3.7 26.3 1.0
C13 A:W5K304 3.9 31.1 0.9
CD1 A:LEU134 4.0 25.6 1.0
C21 A:W5K304 4.1 28.0 0.9
C10 A:W5K304 4.1 31.6 0.9
H41 A:W5K304 4.3 31.1 0.9
H50 A:W5K304 4.4 28.0 0.9
H48 A:W5K304 4.4 28.2 0.9
CG A:LEU45 4.4 30.7 1.0
CG A:LEU134 4.4 25.2 1.0
CH2 A:TRP130 4.5 18.9 1.0
CB A:LEU93 4.6 22.2 1.0
H39 A:W5K304 4.6 31.6 0.9
CD1 A:TRP130 4.6 19.3 1.0
CD2 A:LEU45 4.6 31.4 1.0
CB A:TYR91 4.8 35.7 1.0
C14 A:W5K304 4.9 32.5 0.9
C9 A:W5K304 5.0 33.0 0.9
CD2 A:TRP130 5.0 18.6 1.0
N A:LEU93 5.0 21.4 1.0

Fluorine binding site 2 out of 2 in 8qm7

Go back to Fluorine Binding Sites List in 8qm7
Fluorine binding site 2 out of 2 in the Potential Drug Binding Sites For Translation Initiation Factor EIF4E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Potential Drug Binding Sites For Translation Initiation Factor EIF4E within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F403

b:30.6
occ:0.89
F25 B:W5K403 0.0 30.6 0.9
C24 B:W5K403 1.4 31.3 0.9
C23 B:W5K403 2.4 29.7 0.9
C19 B:W5K403 2.4 32.6 0.9
H51 B:W5K403 2.5 29.7 0.9
H40 B:W5K403 2.7 35.8 0.9
C12 B:W5K403 2.8 34.4 0.9
C11 B:W5K403 3.0 35.8 0.9
NE1 B:TRP130 3.3 25.6 1.0
CZ2 B:TRP130 3.3 26.0 1.0
CD1 B:LEU45 3.4 33.7 1.0
CE2 B:TRP130 3.5 25.6 1.0
CD2 B:LEU134 3.6 30.5 1.0
C22 B:W5K403 3.6 29.1 0.9
C20 B:W5K403 3.6 30.9 0.9
CD1 B:LEU134 3.9 29.0 1.0
C13 B:W5K403 3.9 35.9 0.9
C21 B:W5K403 4.1 29.9 0.9
C10 B:W5K403 4.1 37.0 0.9
H41 B:W5K403 4.3 35.9 0.9
CG B:LEU134 4.3 30.1 1.0
H50 B:W5K403 4.4 29.1 0.9
H48 B:W5K403 4.4 30.9 0.9
CH2 B:TRP130 4.4 25.9 1.0
CD1 B:TRP130 4.5 25.5 1.0
CG B:LEU45 4.5 33.9 1.0
H39 B:W5K403 4.6 37.0 0.9
CB B:LEU93 4.6 28.8 1.0
CD2 B:LEU45 4.7 34.7 1.0
CB B:TYR91 4.8 46.7 1.0
C14 B:W5K403 4.9 37.6 0.9
CD2 B:TRP130 4.9 24.8 1.0
C9 B:W5K403 4.9 39.0 0.9

Reference:

Y.S.Sharp, M.Martella, C.I.Milton, G.Ward, A.J.Woodhead, C.J.Richardson, M.G.Carr, E.Chiarparin, B.D.Cons, J.Coyle, S.D'agostino, C.E.East, S.D.Hiscock, C.Martinez-Fleites, P.N.Mortenson, N.Palmer, P.Pathuri, M.V.Powers, S.M.Saalau, J.D.St.Denis, K.Swabey, M.Vinkovic, G.Williams, P.A.Clarke. Integrating Fragment-Based Screening with Targeted Protein Degradation and Genetic Rescue to Explore EIF4E Function Nat Commun 2025.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-024-54356-1
Page generated: Sat Feb 8 18:14:28 2025

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy