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Fluorine in PDB 8sce: Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide

Enzymatic activity of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide

All present enzymatic activity of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide:
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide, PDB code: 8sce was solved by J.K.Muckelbauer, K.Ghosh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.00 / 1.89
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 135.812, 140.235, 86.949, 90, 126.14, 90
R / Rfree (%) 20.2 / 22.8

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide (pdb code 8sce). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide, PDB code: 8sce:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Fluorine binding site 1 out of 8 in 8sce

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Fluorine binding site 1 out of 8 in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:18.8
occ:1.00
 F2 A:ZVD501 0.0 18.8 1.0
C15 A:ZVD501 1.4 18.7 1.0
H17 A:ZVD501 2.0 18.3 1.0
C16 A:ZVD501 2.4 22.4 1.0
C14 A:ZVD501 2.4 20.7 1.0
O2 A:ZVD501 2.6 24.1 1.0
H16 A:ZVD501 2.7 20.1 1.0
H22 A:ZVD501 2.7 18.9 1.0
N6 A:ZVD501 2.9 24.3 1.0
C18 A:ZVD501 3.0 17.1 1.0
O1 A:ZVD501 3.1 24.3 1.0
O A:HOH645 3.2 19.5 1.0
NH2 A:ARG273 3.2 22.2 1.0
C13 A:ZVD501 3.3 22.6 1.0
CA A:GLY268 3.3 17.1 1.0
N A:GLY268 3.3 17.4 1.0
H15 A:ZVD501 3.3 21.1 1.0
O A:HOH613 3.3 25.9 1.0
H23 A:ZVD501 3.4 15.7 1.0
O A:HOH627 3.4 28.2 1.0
H14 A:ZVD501 3.4 25.1 1.0
H24 A:ZVD501 3.5 24.4 1.0
C17 A:ZVD501 3.7 25.1 1.0
C A:ASN267 3.8 19.2 1.0
H21 A:ZVD501 4.0 16.2 1.0
CZ A:ARG273 4.0 23.2 1.0
H19 A:ZVD501 4.1 24.0 1.0
H20 A:ZVD501 4.1 24.7 1.0
O A:ASN267 4.1 18.9 1.0
H5 A:ZVD501 4.2 23.0 1.0
NH1 A:ARG273 4.3 14.7 1.0
O A:PRO266 4.4 19.0 1.0
C12 A:ZVD501 4.5 19.2 1.0
CA A:ASN267 4.5 15.5 1.0
H18 A:ZVD501 4.5 25.7 1.0
C A:GLY268 4.6 17.8 1.0
O A:MET265 4.7 21.8 1.0
C A:PRO266 4.8 19.2 1.0
N A:SER269 4.9 14.3 1.0
N A:ASN267 4.9 16.3 1.0
N4 A:ZVD501 4.9 24.0 1.0

Fluorine binding site 2 out of 8 in 8sce

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Fluorine binding site 2 out of 8 in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:28.1
occ:1.00
 F1 A:ZVD501 0.0 28.1 1.0
C1 A:ZVD501 1.3 24.6 1.0
C2 A:ZVD501 2.3 23.5 1.0
C4 A:ZVD501 2.4 22.3 1.0
HN3 A:ZVD501 2.4 20.8 1.0
H2 A:ZVD501 2.6 23.4 1.0
N3 A:ZVD501 2.7 20.4 1.0
CB A:TYR262 3.4 19.9 1.0
CD1 A:LEU318 3.5 22.1 1.0
CG1 A:VAL246 3.5 23.7 1.0
O A:VAL263 3.5 26.8 1.0
N1 A:ZVD501 3.5 22.6 1.0
N2 A:ZVD501 3.6 25.9 1.0
CG A:TYR262 3.7 23.8 1.0
O A:HOH691 3.7 35.2 1.0
CB A:VAL246 3.8 24.1 1.0
CG A:MET265 3.9 25.8 1.0
C3 A:ZVD501 4.0 26.2 1.0
CD2 A:TYR262 4.0 24.2 1.0
C5 A:ZVD501 4.1 17.4 1.0
CD1 A:TYR262 4.4 25.7 1.0
CG2 A:VAL246 4.5 23.8 1.0
CB A:ALA211 4.7 19.7 1.0
C A:VAL263 4.7 25.1 1.0
N5 A:ZVD501 4.7 18.2 1.0
CG A:LEU318 4.8 21.7 1.0
CA A:TYR262 4.8 17.8 1.0
H4 A:ZVD501 4.9 17.4 1.0
SD A:MET265 4.9 31.1 1.0
CE2 A:TYR262 4.9 25.7 1.0
N A:VAL263 4.9 20.2 1.0
C6 A:ZVD501 5.0 18.1 1.0

Fluorine binding site 3 out of 8 in 8sce

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Fluorine binding site 3 out of 8 in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F501

b:21.7
occ:1.00
 F2 B:ZVD501 0.0 21.7 1.0
C15 B:ZVD501 1.3 19.9 1.0
H17 B:ZVD501 2.0 18.9 1.0
C14 B:ZVD501 2.3 18.6 1.0
C16 B:ZVD501 2.4 23.2 1.0
H22 B:ZVD501 2.6 20.8 1.0
H16 B:ZVD501 2.6 16.4 1.0
O2 B:ZVD501 2.7 26.8 1.0
N6 B:ZVD501 2.9 24.1 1.0
C18 B:ZVD501 2.9 21.6 1.0
O1 B:ZVD501 3.0 20.3 1.0
NH2 B:ARG273 3.2 20.9 1.0
C13 B:ZVD501 3.2 22.1 1.0
H23 B:ZVD501 3.2 20.6 1.0
O B:HOH630 3.3 18.9 1.0
CA B:GLY268 3.3 16.3 1.0
H15 B:ZVD501 3.3 17.6 1.0
N B:GLY268 3.3 17.1 1.0
O B:HOH656 3.4 24.1 1.0
O B:HOH620 3.4 23.0 1.0
H14 B:ZVD501 3.5 24.4 1.0
H24 B:ZVD501 3.6 27.5 1.0
C17 B:ZVD501 3.7 25.0 1.0
C B:ASN267 3.7 21.7 1.0
H21 B:ZVD501 3.9 20.9 1.0
H20 B:ZVD501 4.0 25.7 1.0
CZ B:ARG273 4.0 22.9 1.0
O B:ASN267 4.1 19.6 1.0
H19 B:ZVD501 4.1 23.7 1.0
H5 B:ZVD501 4.2 23.9 1.0
NH1 B:ARG273 4.3 20.1 1.0
O B:PRO266 4.4 20.8 1.0
CA B:ASN267 4.4 17.6 1.0
C12 B:ZVD501 4.5 20.3 1.0
H18 B:ZVD501 4.5 25.4 1.0
C B:GLY268 4.5 19.1 1.0
O B:MET265 4.8 19.7 1.0
C B:PRO266 4.8 21.4 1.0
N B:SER269 4.9 16.5 1.0
N B:ASN267 4.9 18.2 1.0

Fluorine binding site 4 out of 8 in 8sce

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Fluorine binding site 4 out of 8 in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F501

b:26.7
occ:1.00
 F1 B:ZVD501 0.0 26.7 1.0
C1 B:ZVD501 1.3 26.9 1.0
HN3 B:ZVD501 2.3 21.2 1.0
C4 B:ZVD501 2.3 23.4 1.0
C2 B:ZVD501 2.4 25.7 1.0
H2 B:ZVD501 2.7 25.4 1.0
N3 B:ZVD501 2.7 22.1 1.0
CB B:TYR262 3.3 20.6 1.0
O B:VAL263 3.4 23.2 1.0
O B:HOH685 3.5 37.4 1.0
N2 B:ZVD501 3.6 25.3 1.0
N1 B:ZVD501 3.6 24.2 1.0
CG1 B:VAL246 3.6 23.3 1.0
CD1 B:LEU318 3.7 22.7 1.0
CG B:TYR262 3.7 24.7 1.0
CB B:VAL246 3.8 23.4 1.0
CG B:MET265 4.0 23.8 1.0
C3 B:ZVD501 4.0 23.4 1.0
C5 B:ZVD501 4.0 20.9 1.0
CD2 B:TYR262 4.1 25.9 1.0
CG2 B:VAL246 4.4 24.1 1.0
CD1 B:TYR262 4.5 28.3 1.0
CB B:ALA211 4.6 18.3 1.0
C B:VAL263 4.6 23.2 1.0
CA B:TYR262 4.7 18.8 1.0
N5 B:ZVD501 4.7 21.1 1.0
N B:VAL263 4.8 17.3 1.0
H4 B:ZVD501 4.8 19.0 1.0
C B:TYR262 4.8 20.9 1.0
C6 B:ZVD501 4.9 19.1 1.0
CE2 B:TYR262 5.0 27.2 1.0
SD B:MET265 5.0 29.3 1.0

Fluorine binding site 5 out of 8 in 8sce

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Fluorine binding site 5 out of 8 in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F502

b:20.9
occ:1.00
 F2 D:ZVD502 0.0 20.9 1.0
C15 D:ZVD502 1.3 21.4 1.0
H17 D:ZVD502 2.0 22.1 1.0
C14 D:ZVD502 2.3 24.2 1.0
C16 D:ZVD502 2.4 23.9 1.0
H23 D:ZVD502 2.6 22.3 1.0
H16 D:ZVD502 2.7 23.0 1.0
O2 D:ZVD502 2.7 24.9 1.0
N6 D:ZVD502 2.8 26.5 1.0
C18 D:ZVD502 2.9 23.0 1.0
NH2 D:ARG273 3.1 17.6 1.0
O D:HOH618 3.2 22.9 1.0
CA D:GLY268 3.2 20.1 1.0
O1 D:ZVD502 3.2 31.0 1.0
C13 D:ZVD502 3.2 27.2 1.0
H22 D:ZVD502 3.2 22.5 1.0
H15 D:ZVD502 3.3 24.0 1.0
N D:GLY268 3.3 18.6 1.0
H14 D:ZVD502 3.4 26.1 1.0
O D:HOH622 3.4 31.3 1.0
O D:HOH648 3.4 28.8 1.0
H24 D:ZVD502 3.5 25.0 1.0
C D:ASN267 3.7 20.6 1.0
C17 D:ZVD502 3.8 24.8 1.0
H21 D:ZVD502 3.9 23.5 1.0
CZ D:ARG273 4.0 28.9 1.0
H20 D:ZVD502 4.1 24.8 1.0
O D:ASN267 4.1 20.1 1.0
H19 D:ZVD502 4.1 23.8 1.0
H5 D:ZVD502 4.2 20.7 1.0
NH1 D:ARG273 4.3 20.2 1.0
C12 D:ZVD502 4.4 23.7 1.0
O D:PRO266 4.4 23.3 1.0
CA D:ASN267 4.5 16.7 1.0
C D:GLY268 4.5 23.1 1.0
H18 D:ZVD502 4.6 24.1 1.0
O D:MET265 4.7 22.4 1.0
N D:SER269 4.8 19.9 1.0
C D:PRO266 4.9 22.6 1.0
N D:ASN267 4.9 17.0 1.0
N4 D:ZVD502 4.9 21.1 1.0

Fluorine binding site 6 out of 8 in 8sce

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Fluorine binding site 6 out of 8 in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
D:F502

b:31.4
occ:1.00
 F1 D:ZVD502 0.0 31.4 1.0
C1 D:ZVD502 1.3 28.7 1.0
HN3 D:ZVD502 2.3 26.8 1.0
C2 D:ZVD502 2.3 25.6 1.0
C4 D:ZVD502 2.3 27.2 1.0
H2 D:ZVD502 2.6 25.6 1.0
N3 D:ZVD502 2.7 27.2 1.0
CB D:TYR262 3.3 25.4 1.0
O D:VAL263 3.3 30.0 1.0
N1 D:ZVD502 3.6 26.9 1.0
N2 D:ZVD502 3.6 27.8 1.0
CD1 D:LEU318 3.6 26.6 1.0
CG D:TYR262 3.8 28.4 1.0
CG D:MET265 3.8 27.8 1.0
CG1 D:VAL246 3.9 31.3 1.0
C3 D:ZVD502 4.0 28.1 1.0
C5 D:ZVD502 4.0 24.2 1.0
CB D:VAL246 4.1 29.8 1.0
CD2 D:TYR262 4.2 29.7 1.0
CD1 D:TYR262 4.4 30.8 1.0
C D:VAL263 4.5 30.7 1.0
N D:VAL263 4.6 23.9 1.0
CA D:TYR262 4.6 23.7 1.0
CB D:ALA211 4.6 25.0 1.0
CG2 D:VAL246 4.6 30.2 1.0
N5 D:ZVD502 4.7 25.0 1.0
C D:TYR262 4.7 26.5 1.0
SD D:MET265 4.8 31.8 1.0
H4 D:ZVD502 4.8 23.8 1.0
C6 D:ZVD502 4.9 23.6 1.0
CE D:MET265 5.0 28.3 1.0
CB D:MET265 5.0 24.6 1.0

Fluorine binding site 7 out of 8 in 8sce

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Fluorine binding site 7 out of 8 in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F503

b:23.7
occ:1.00
 F2 E:ZVD503 0.0 23.7 1.0
C15 E:ZVD503 1.4 22.8 1.0
H17 E:ZVD503 2.0 21.6 1.0
C14 E:ZVD503 2.4 22.7 1.0
C16 E:ZVD503 2.4 25.4 1.0
H16 E:ZVD503 2.7 23.0 1.0
O2 E:ZVD503 2.7 27.1 1.0
N6 E:ZVD503 2.8 22.1 1.0
H22 E:ZVD503 3.0 23.9 1.0
C18 E:ZVD503 3.0 24.6 1.0
H23 E:ZVD503 3.1 23.4 1.0
O E:HOH604 3.1 29.0 1.0
NH2 E:ARG273 3.1 22.2 1.0
O E:HOH627 3.2 25.5 1.0
O1 E:ZVD503 3.2 31.3 1.0
C13 E:ZVD503 3.3 25.9 1.0
CA E:GLY268 3.3 19.3 1.0
H15 E:ZVD503 3.3 22.2 1.0
N E:GLY268 3.3 19.8 1.0
O E:HOH626 3.3 29.3 1.0
H14 E:ZVD503 3.3 22.4 1.0
H24 E:ZVD503 3.6 27.8 1.0
C17 E:ZVD503 3.8 29.5 1.0
C E:ASN267 3.8 22.1 1.0
CZ E:ARG273 4.0 28.6 1.0
H21 E:ZVD503 4.1 24.9 1.0
H20 E:ZVD503 4.1 28.7 1.0
H19 E:ZVD503 4.1 29.8 1.0
O E:ASN267 4.1 21.1 1.0
H5 E:ZVD503 4.2 28.4 1.0
NH1 E:ARG273 4.3 16.4 1.0
C12 E:ZVD503 4.5 24.4 1.0
O E:PRO266 4.5 22.7 1.0
CA E:ASN267 4.5 17.2 1.0
C E:GLY268 4.6 21.6 1.0
H18 E:ZVD503 4.6 29.8 1.0
O E:MET265 4.7 20.6 1.0
N E:SER269 4.8 18.9 1.0
C E:PRO266 4.9 23.0 1.0
N E:ASN267 4.9 16.7 1.0
N4 E:ZVD503 5.0 28.8 1.0

Fluorine binding site 8 out of 8 in 8sce

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Fluorine binding site 8 out of 8 in the Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Crystal Structure of IRAK4-Hsa Complexed with N-[(2R)-2-Fluoro-3- Hydroxy-3-Methylbutyl]-6-[(5-Fluoropyri-Yl)Amino]-4-[(Propan-2-Yl) Amino]Pyridine-3-Carboxamide within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F503

b:32.6
occ:1.00
 F1 E:ZVD503 0.0 32.6 1.0
C1 E:ZVD503 1.3 28.3 1.0
HN3 E:ZVD503 2.3 25.5 1.0
C2 E:ZVD503 2.4 27.9 1.0
C4 E:ZVD503 2.4 26.8 1.0
H2 E:ZVD503 2.6 27.6 1.0
N3 E:ZVD503 2.7 25.6 1.0
CB E:TYR262 3.3 26.4 1.0
O E:VAL263 3.5 27.5 1.0
CD1 E:LEU318 3.6 26.3 1.0
N1 E:ZVD503 3.6 30.1 1.0
N2 E:ZVD503 3.6 28.8 1.0
CG1 E:VAL246 3.6 32.5 1.0
CG E:TYR262 3.7 28.4 1.0
CB E:VAL246 3.9 32.5 1.0
CG E:MET265 4.0 27.4 1.0
C3 E:ZVD503 4.0 30.7 1.0
CD2 E:TYR262 4.0 29.2 1.0
C5 E:ZVD503 4.1 25.4 1.0
CD1 E:TYR262 4.3 30.8 1.0
CG2 E:VAL246 4.5 32.7 1.0
CB E:ALA211 4.6 23.0 1.0
CA E:TYR262 4.7 25.1 1.0
C E:VAL263 4.7 29.9 1.0
N5 E:ZVD503 4.7 27.3 1.0
N E:VAL263 4.8 27.4 1.0
C E:TYR262 4.9 30.2 1.0
H4 E:ZVD503 4.9 23.5 1.0
CG E:LEU318 5.0 26.1 1.0
CE2 E:TYR262 5.0 29.9 1.0
SD E:MET265 5.0 31.0 1.0
C6 E:ZVD503 5.0 24.4 1.0

Reference:

S.R.Kumar, S.Dudhgoankar, J.B.Santella, V.R.R.Paidi, S.Nair, R.Sistla, H.Wu, D.S.Gardner, S.Stachura, C.L.Cavallaro, G.D.Brown, W.J.Pitts, J.Kempson, A.J.Tebben, J.S.Tokarski, X.Zhu, J.A.Carman, K.Foster, J.Caceres Cortes, G.Everlof, M.A.Galella, A.Sarjeant, D.A.Holloway, L.Fan, X.Li, C.Chaudhry, G.Locke, A.Chimalakondra, T.T.Mariappan, S.Ruepp, P.A.Elzinga, A.Saxena, D.Xie, S.E.Kiefer, C.Yan, J.A.Newitt, K.Ghosh, R.K.Anumula, J.S.Sack, J.A.Tino, P.H.Carter, J.Hynes, J.V.Duncia. The Discovery of IRAK4 Inhibitor Clinical Candidates Bms-986126 and Bms-986147 For the Treatment of Autoimmune Diseases To Be Published.
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