Fluorine in PDB 8udr: Structure of the P1B7 Antibody Bound to the Sotorasib-Modified Kras G12C Peptide Presented By the A*03:01 Mhc I Complex

The binding sites of Fluorine atom in the Structure of the P1B7 Antibody Bound to the Sotorasib-Modified Kras G12C Peptide Presented By the A*03:01 Mhc I Complex (pdb code 8udr). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of the P1B7 Antibody Bound to the Sotorasib-Modified Kras G12C Peptide Presented By the A*03:01 Mhc I Complex, PDB code: 8udr:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Structure of the P1B7 Antibody Bound to the Sotorasib-Modified Kras G12C Peptide Presented By the A*03:01 Mhc I Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of the P1B7 Antibody Bound to the Sotorasib-Modified Kras G12C Peptide Presented By the A*03:01 Mhc I Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:F301 b:20.1 occ:1.00 F1 D:MOV301 0.0 20.1 1.0 C4 D:MOV301 1.4 20.1 1.0 C3 D:MOV301 2.3 20.1 1.0 C5 D:MOV301 2.4 20.1 1.0 HG23 E:THR118 2.9 23.1 1.0 C6 D:MOV301 2.9 20.1 1.0 F2 D:MOV301 3.0 20.1 1.0 HG21 E:THR118 3.1 23.1 1.0 C30 D:MOV301 3.1 20.1 1.0 CG2 E:THR118 3.5 23.1 1.0 N1 D:MOV301 3.6 20.1 1.0 C1 D:MOV301 3.6 20.1 1.0 HG13 A:VAL76 3.7 17.4 1.0 HG12 A:VAL76 3.8 17.4 1.0 C26 D:MOV301 3.8 20.1 1.0 HG22 E:THR118 3.9 23.1 1.0 C2 D:MOV301 4.1 20.1 1.0 CG1 A:VAL76 4.3 17.4 1.0 C29 D:MOV301 4.3 20.1 1.0 O3 D:MOV301 4.3 20.1 1.0 HB E:THR118 4.7 23.1 1.0 CB E:THR118 4.7 23.1 1.0 HG11 A:VAL76 4.7 17.4 1.0 C27 D:MOV301 4.8 20.1 1.0 C17 D:MOV301 4.9 20.1 1.0 C7 D:MOV301 4.9 20.1 1.0 C28 D:MOV301 5.0 20.1 1.0

Fluorine binding site 2 out of 2 in the Structure of the P1B7 Antibody Bound to the Sotorasib-Modified Kras G12C Peptide Presented By the A*03:01 Mhc I Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of the P1B7 Antibody Bound to the Sotorasib-Modified Kras G12C Peptide Presented By the A*03:01 Mhc I Complex within 5.0Å range: probe atom residue distance (Å) B Occ D:F301 b:20.1 occ:1.00 F2 D:MOV301 0.0 20.1 1.0 C30 D:MOV301 1.4 20.1 1.0 C29 D:MOV301 2.4 20.1 1.0 C6 D:MOV301 2.4 20.1 1.0 HG12 A:VAL76 2.6 17.4 1.0 C3 D:MOV301 2.9 20.1 1.0 F1 D:MOV301 3.0 20.1 1.0 C4 D:MOV301 3.2 20.1 1.0 CG1 A:VAL76 3.6 17.4 1.0 C28 D:MOV301 3.6 20.1 1.0 C26 D:MOV301 3.6 20.1 1.0 HG11 A:VAL76 3.8 17.4 1.0 N1 D:MOV301 3.8 20.1 1.0 HG13 A:VAL76 3.9 17.4 1.0 HG23 E:THR118 3.9 23.1 1.0 HG2 D:PRO127 4.1 21.3 1.0 C27 D:MOV301 4.1 20.1 1.0 C5 D:MOV301 4.3 20.1 1.0 HG23 A:VAL76 4.5 17.4 1.0 HA A:VAL76 4.5 17.4 1.0 HG1 A:THR80 4.6 18.0 1.0 OG1 A:THR80 4.7 18.0 1.0 O3 D:MOV301 4.8 20.1 1.0 C2 D:MOV301 4.8 20.1 1.0 CB A:VAL76 4.8 17.4 1.0 O A:VAL76 4.8 17.4 1.0 C15 D:MOV301 5.0 20.1 1.0 CG2 E:THR118 5.0 23.1 1.0 C1 D:MOV301 5.0 20.1 1.0

A.Pandey, P.J.Rohweder, L.M.Chan, C.Ongpipattanakul, D.Chung, B.Paolella, F.M.Quimby, N.Nguyen, K.A.Verba, M.J.Evans, C.S.Craik. Therapeutic Targeting and Structural Characterization of A Sotorasib-Haptenated Kras G12C Mhc I Complex To Be Published.