Fluorine in PDB 8uqo: PLCB3-Gbg-Gaq Complex on Membranes

All present enzymatic activity of PLCB3-Gbg-Gaq Complex on Membranes:
3.1.4.11;

The structure of PLCB3-Gbg-Gaq Complex on Membranes also contains other interesting chemical elements:

Aluminium	(Al)	1 atom
Magnesium	(Mg)	1 atom
Calcium	(Ca)	1 atom

The binding sites of Fluorine atom in the PLCB3-Gbg-Gaq Complex on Membranes (pdb code 8uqo). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the PLCB3-Gbg-Gaq Complex on Membranes, PDB code: 8uqo:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the PLCB3-Gbg-Gaq Complex on Membranes


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of PLCB3-Gbg-Gaq Complex on Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:72.8 occ:1.00 F1 A:ALF402 0.0 72.8 1.0 AL A:ALF402 1.8 72.8 1.0 O2B A:GDP401 2.4 43.2 1.0 F3 A:ALF402 2.5 72.8 1.0 F4 A:ALF402 2.5 72.8 1.0 CB A:THR186 2.6 36.1 1.0 O1B A:GDP401 2.7 43.2 1.0 PB A:GDP401 2.8 43.2 1.0 O3B A:GDP401 2.9 43.2 1.0 N A:THR186 3.0 36.1 1.0 MG A:MG403 3.1 67.9 1.0 O A:HOH501 3.1 20.0 1.0 CA A:THR186 3.3 36.1 1.0 CG2 A:THR186 3.4 36.1 1.0 H2 A:HOH501 3.5 20.0 1.0 O A:THR186 3.5 36.1 1.0 OG1 A:THR186 3.5 36.1 1.0 F2 A:ALF402 3.6 72.8 1.0 C A:THR186 3.9 36.1 1.0 H1 A:HOH501 3.9 20.0 1.0 C A:PRO185 4.3 40.6 1.0 O A:VAL206 4.4 32.8 1.0 O3A A:GDP401 4.4 43.2 1.0 NZ A:LYS52 4.4 36.2 1.0 N A:GLY208 4.5 35.8 1.0 CA A:GLY207 4.6 33.0 1.0 CA A:PRO185 4.6 40.6 1.0 C A:GLY207 4.8 33.0 1.0 CE A:LYS52 4.9 36.2 1.0 O A:VAL184 4.9 40.3 1.0

Fluorine binding site 2 out of 4 in the PLCB3-Gbg-Gaq Complex on Membranes


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of PLCB3-Gbg-Gaq Complex on Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:72.8 occ:1.00 F2 A:ALF402 0.0 72.8 1.0 AL A:ALF402 1.8 72.8 1.0 F4 A:ALF402 2.5 72.8 1.0 F3 A:ALF402 2.5 72.8 1.0 O A:HOH501 2.6 20.0 1.0 H1 A:HOH501 2.9 20.0 1.0 OE1 A:GLN209 3.0 40.6 1.0 N A:GLU49 3.0 42.3 1.0 O1B A:GDP401 3.1 43.2 1.0 CA A:GLY48 3.3 41.8 1.0 O3B A:GDP401 3.3 43.2 1.0 H2 A:HOH501 3.4 20.0 1.0 F1 A:ALF402 3.6 72.8 1.0 C A:GLY48 3.6 41.8 1.0 NH2 A:ARG183 3.8 40.6 1.0 PB A:GDP401 3.9 43.2 1.0 CA A:GLU49 4.1 42.3 1.0 CD A:GLN209 4.1 40.6 1.0 CA A:GLY208 4.2 35.8 1.0 N A:GLY208 4.3 35.8 1.0 C A:GLY208 4.4 35.8 1.0 N A:GLY48 4.6 41.8 1.0 NZ A:LYS52 4.6 36.2 1.0 CZ A:ARG183 4.6 40.6 1.0 NH1 A:ARG183 4.6 40.6 1.0 N A:GLN209 4.7 40.6 1.0 CG A:GLN209 4.7 40.6 1.0 O A:THR47 4.8 38.9 1.0 O2B A:GDP401 4.8 43.2 1.0 O A:GLY48 4.9 41.8 1.0 CB A:GLU49 4.9 42.3 1.0 O A:GLY208 5.0 35.8 1.0

Fluorine binding site 3 out of 4 in the PLCB3-Gbg-Gaq Complex on Membranes


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of PLCB3-Gbg-Gaq Complex on Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:72.8 occ:1.00 F3 A:ALF402 0.0 72.8 1.0 AL A:ALF402 1.8 72.8 1.0 O3B A:GDP401 2.2 43.2 1.0 F1 A:ALF402 2.5 72.8 1.0 NZ A:LYS52 2.5 36.2 1.0 F2 A:ALF402 2.5 72.8 1.0 N A:GLY208 3.1 35.8 1.0 CA A:GLY208 3.1 35.8 1.0 O A:HOH501 3.2 20.0 1.0 PB A:GDP401 3.3 43.2 1.0 CE A:LYS52 3.4 36.2 1.0 H2 A:HOH501 3.5 20.0 1.0 O1B A:GDP401 3.5 43.2 1.0 F4 A:ALF402 3.6 72.8 1.0 C A:GLY207 3.6 33.0 1.0 O2B A:GDP401 3.7 43.2 1.0 H1 A:HOH501 4.0 20.0 1.0 O A:THR47 4.1 38.9 1.0 O A:GLY207 4.1 33.0 1.0 CA A:GLY48 4.2 41.8 1.0 C A:GLY208 4.2 35.8 1.0 CA A:GLY207 4.2 33.0 1.0 O A:VAL206 4.3 32.8 1.0 N A:GLU49 4.4 42.3 1.0 O3A A:GDP401 4.7 43.2 1.0 CD A:LYS52 4.7 36.2 1.0 C A:THR47 4.8 38.9 1.0 CB A:THR186 4.8 36.1 1.0 C A:GLY48 4.8 41.8 1.0 N A:GLN209 4.8 40.6 1.0 O A:THR186 4.9 36.1 1.0 O A:GLY208 4.9 35.8 1.0 N A:GLY48 4.9 41.8 1.0 MG A:MG403 5.0 67.9 1.0 CG A:LYS52 5.0 36.2 1.0

Fluorine binding site 4 out of 4 in the PLCB3-Gbg-Gaq Complex on Membranes


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of PLCB3-Gbg-Gaq Complex on Membranes within 5.0Å range: probe atom residue distance (Å) B Occ A:F402 b:72.8 occ:1.00 F4 A:ALF402 0.0 72.8 1.0 AL A:ALF402 1.8 72.8 1.0 O1B A:GDP401 2.2 43.2 1.0 O A:HOH501 2.5 20.0 1.0 F2 A:ALF402 2.5 72.8 1.0 F1 A:ALF402 2.5 72.8 1.0 H1 A:HOH501 2.6 20.0 1.0 NH2 A:ARG183 2.9 40.6 1.0 N A:THR186 3.0 36.1 1.0 CA A:PRO185 3.1 40.6 1.0 H2 A:HOH501 3.4 20.0 1.0 PB A:GDP401 3.4 43.2 1.0 C A:PRO185 3.5 40.6 1.0 F3 A:ALF402 3.6 72.8 1.0 CB A:PRO185 3.6 40.6 1.0 CZ A:ARG183 3.8 40.6 1.0 O3B A:GDP401 3.8 43.2 1.0 O2B A:GDP401 3.8 43.2 1.0 O A:THR186 3.9 36.1 1.0 CA A:THR186 4.1 36.1 1.0 CB A:THR186 4.3 36.1 1.0 NH1 A:ARG183 4.4 40.6 1.0 N A:PRO185 4.4 40.6 1.0 C A:THR186 4.5 36.1 1.0 O A:VAL184 4.5 40.3 1.0 OE1 A:GLN209 4.5 40.6 1.0 O1A A:GDP401 4.5 43.2 1.0 NE A:ARG183 4.5 40.6 1.0 O A:PRO185 4.6 40.6 1.0 O3A A:GDP401 4.8 43.2 1.0 C A:VAL184 4.9 40.3 1.0 N A:GLU49 5.0 42.3 1.0

M.E.Falzone, R.Mackinnon. The Mechanism of G Alpha Q Regulation of Plc Beta 3 -Catalyzed PIP2 Hydrolysis. Proc.Natl.Acad.Sci.Usa V. 120 11120 2023.
ISSN: ESSN 1091-6490
PubMed: 37991948
DOI: 10.1073/PNAS.2315011120