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Fluorine in PDB 8wkf: Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis
Enzymatic activity of Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis
All present enzymatic activity of Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis:
3.1.4.35;
3.1.4.35;
Protein crystallography data
The structure of Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis, PDB code: 8wkf
was solved by
F.C.Zhang,
Y.Y.Huang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 23.01 / 2.40 |
| Space group | P 31 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.428, 74.428, 131.478, 90, 90, 120 |
| R / Rfree (%) | 19.6 / 24.8 |
Other elements in 8wkf:
The structure of Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
| Chlorine | (Cl) | 1 atom |
| Zinc | (Zn) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis
(pdb code 8wkf). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis, PDB code: 8wkf:
In total only one binding site of Fluorine was determined in the Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis, PDB code: 8wkf:
Fluorine binding site 1 out of 1 in 8wkf
Go back to
Fluorine Binding Sites List in 8wkf
Fluorine binding site 1 out
of 1 in the Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis within 5.0Å range:
|
Reference:
F.C.Zhang,
Y.Y.Huang.
Rational Design of Highly Selective PDE5 Inhibitors For the Treatment of Idiopathic Pulmonary Fibrosis To Be Published.
Page generated: Wed Jul 16 10:02:36 2025
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