Fluorine in PDB 8wpg: Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent

The structure of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

The binding sites of Fluorine atom in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent (pdb code 8wpg). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent, PDB code: 8wpg:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ B:F909 b:123.6 occ:1.00 F1 B:YP4909 0.0 123.6 1.0 C12 B:YP4909 1.3 125.5 1.0 F2 B:YP4909 2.1 125.9 1.0 F3 B:YP4909 2.1 125.8 1.0 O B:TRP818 2.2 120.5 1.0 C8 B:YP4909 2.4 124.4 1.0 C9 B:YP4909 2.8 123.6 1.0 CD1 B:ILE822 3.3 132.5 1.0 C B:TRP818 3.4 122.1 1.0 C7 B:YP4909 3.7 122.8 1.0 CE3 B:TRP818 4.0 120.0 1.0 CB B:TRP818 4.0 119.9 1.0 CA B:TRP818 4.1 120.8 1.0 C10 B:YP4909 4.2 122.6 1.0 N B:ILE819 4.4 132.3 1.0 CG1 B:ILE822 4.5 133.1 1.0 CA B:ILE819 4.6 132.3 1.0 CD2 B:TRP818 4.6 119.7 1.0 CG B:TRP818 4.7 120.3 1.0 C6 B:YP4909 4.8 122.0 1.0 CZ3 B:TRP818 4.9 120.2 1.0

Fluorine binding site 2 out of 6 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ B:F909 b:125.9 occ:1.00 F2 B:YP4909 0.0 125.9 1.0 C12 B:YP4909 1.3 125.5 1.0 F1 B:YP4909 2.1 123.6 1.0 F3 B:YP4909 2.1 125.8 1.0 C8 B:YP4909 2.4 124.4 1.0 C7 B:YP4909 3.0 122.8 1.0 C9 B:YP4909 3.5 123.6 1.0 CE2 B:YP4909 3.5 121.7 1.0 O B:TRP818 3.9 120.5 1.0 CD2 B:YP4909 4.0 122.0 1.0 CE3 B:TRP818 4.1 120.0 1.0 CD1 B:ILE777 4.1 146.6 1.0 CZ B:YP4909 4.1 123.3 1.0 C6 B:YP4909 4.3 122.0 1.0 CB B:TRP818 4.5 119.9 1.0 CD2 B:TRP818 4.6 119.7 1.0 C10 B:YP4909 4.6 122.6 1.0 CZ3 B:TRP818 4.8 120.2 1.0 CG B:TRP818 4.8 120.3 1.0 CB B:ILE777 4.9 145.5 1.0 C B:TRP818 4.9 122.1 1.0 CG B:YP4909 5.0 122.7 1.0 C11 B:YP4909 5.0 122.4 1.0 CG1 B:ILE777 5.0 147.7 1.0

Fluorine binding site 3 out of 6 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ B:F909 b:125.8 occ:1.00 F3 B:YP4909 0.0 125.8 1.0 C12 B:YP4909 1.3 125.5 1.0 F1 B:YP4909 2.1 123.6 1.0 F2 B:YP4909 2.1 125.9 1.0 C8 B:YP4909 2.4 124.4 1.0 C7 B:YP4909 3.0 122.8 1.0 C9 B:YP4909 3.4 123.6 1.0 CD1 B:ILE777 3.9 146.6 1.0 CD1 B:ILE822 4.0 132.5 1.0 O B:TRP818 4.2 120.5 1.0 C6 B:YP4909 4.3 122.0 1.0 C10 B:YP4909 4.6 122.6 1.0 C11 B:YP4909 4.9 122.4 1.0

Fluorine binding site 4 out of 6 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ A:F906 b:122.7 occ:1.00 F1 A:YP4906 0.0 122.7 1.0 C12 A:YP4906 1.3 121.8 1.0 F2 A:YP4906 2.1 121.8 1.0 F3 A:YP4906 2.1 120.8 1.0 O A:TRP818 2.2 120.0 1.0 C8 A:YP4906 2.4 120.7 1.0 C9 A:YP4906 2.8 119.6 1.0 C A:TRP818 3.3 118.4 1.0 CB A:TRP818 3.6 117.4 1.0 C7 A:YP4906 3.7 120.3 1.0 CD1 A:ILE822 3.8 131.5 1.0 CG1 A:ILE822 4.0 132.0 1.0 CA A:TRP818 4.0 117.5 1.0 C10 A:YP4906 4.2 120.3 1.0 N A:ILE819 4.3 125.0 1.0 CE3 A:TRP818 4.5 118.5 1.0 CA A:ILE819 4.5 127.0 1.0 CG A:TRP818 4.7 119.3 1.0 C6 A:YP4906 4.8 120.9 1.0 CD2 A:TRP818 4.9 119.1 1.0

Fluorine binding site 5 out of 6 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ A:F906 b:121.8 occ:1.00 F2 A:YP4906 0.0 121.8 1.0 C12 A:YP4906 1.3 121.8 1.0 F1 A:YP4906 2.1 122.7 1.0 F3 A:YP4906 2.1 120.8 1.0 C8 A:YP4906 2.4 120.7 1.0 C7 A:YP4906 3.1 120.3 1.0 CB A:TRP818 3.2 117.4 1.0 C9 A:YP4906 3.4 119.6 1.0 CE2 A:YP4906 3.5 119.8 1.0 CE3 A:TRP818 3.5 118.5 1.0 O A:TRP818 3.6 120.0 1.0 CG A:TRP818 3.8 119.3 1.0 CD2 A:TRP818 3.8 119.1 1.0 CZ A:YP4906 4.2 120.9 1.0 CA A:TRP818 4.3 117.5 1.0 C A:TRP818 4.3 118.4 1.0 CD2 A:YP4906 4.3 120.9 1.0 C6 A:YP4906 4.4 120.9 1.0 CZ3 A:TRP818 4.6 117.8 1.0 C10 A:YP4906 4.6 120.3 1.0 CG2 A:ILE777 4.8 144.6 1.0 CD1 A:TRP818 4.9 119.1 1.0 C11 A:YP4906 5.0 120.5 1.0

Fluorine binding site 6 out of 6 in the Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human Calcium-Sensing Receptor Bound with Cinacalcet in Detergent within 5.0Å range: probe atom residue distance (Å) B Occ A:F906 b:120.8 occ:1.00 F3 A:YP4906 0.0 120.8 1.0 C12 A:YP4906 1.3 121.8 1.0 F1 A:YP4906 2.1 122.7 1.0 F2 A:YP4906 2.1 121.8 1.0 C8 A:YP4906 2.4 120.7 1.0 C7 A:YP4906 2.9 120.3 1.0 C9 A:YP4906 3.5 119.6 1.0 CG2 A:ILE777 4.2 144.6 1.0 C6 A:YP4906 4.2 120.9 1.0 O A:TRP818 4.3 120.0 1.0 C10 A:YP4906 4.7 120.3 1.0 CE2 A:YP4906 4.9 119.8 1.0 C11 A:YP4906 4.9 120.5 1.0

S.Ling, X.Meng, Y.Zhang, Z.Xia, Y.Zhou, F.Yang, P.Shi, C.Shi, C.Tian. Structural Insights Into Asymmetric Activation of the Calcium-Sensing Receptor-G Q Complex. Cell Res. 2023.
ISSN: ISSN 1001-0602
PubMed: 37919470
DOI: 10.1038/S41422-023-00892-2