Fluorine in PDB 9b65: Biased Agonist Bound CB1-Gi Structure

The binding sites of Fluorine atom in the Biased Agonist Bound CB1-Gi Structure (pdb code 9b65). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Biased Agonist Bound CB1-Gi Structure, PDB code: 9b65:

Fluorine binding site 1 out of 1 in the Biased Agonist Bound CB1-Gi Structure


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Biased Agonist Bound CB1-Gi Structure within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:126.0 occ:1.00 FAU R:KCA501 0.0 126.0 1.0 CAT R:KCA501 1.4 126.0 1.0 CAV R:KCA501 2.4 126.0 1.0 CAS R:KCA501 2.4 126.0 1.0 H19 R:KCA501 2.5 126.0 1.0 H18 R:KCA501 2.6 126.0 1.0 CD2 R:LEU193 3.0 127.2 1.0 CE2 R:TYR275 3.1 125.8 1.0 OH R:TYR275 3.6 125.8 1.0 CAW R:KCA501 3.6 126.0 1.0 CAR R:KCA501 3.6 126.0 1.0 CZ R:TYR275 3.8 125.8 1.0 CD2 R:TYR275 4.1 125.8 1.0 CAQ R:KCA501 4.1 126.0 1.0 CG R:LEU193 4.1 127.2 1.0 CB R:THR197 4.3 121.8 1.0 H20 R:KCA501 4.4 126.0 1.0 CD1 R:LEU193 4.4 127.2 1.0 H17 R:KCA501 4.4 126.0 1.0 CG2 R:THR197 4.4 121.8 1.0 OG1 R:THR197 4.6 121.8 1.0 O R:ALA248 4.8 128.2 1.0 O R:ILE247 4.8 126.6 1.0 CG1 R:ILE271 5.0 133.3 1.0

V.A.Rangari, E.S.O'brien, A.S.Powers, R.Slivicki, Z.Bertels, K.Appourchaux, D.Aydin, N.Ramos-Gonzalez, J.Mwirigi, L.Lin, E.Mangutov, B.L.Sobecks, Y.Awad-Agbaria, M.B.Uphade, J.Aguilar, T.N.Peddada, Y.Shiimura, X.-P.Huang, J.Folarin-Hines, M.Payne, A.Kalathil, B.R.Varga, B.K.Kobilka, A.A.Pradhan, M.D.Cameron, K.K.Kumar, R.O.Dror, R.W.Gereau, S.Majumdar. A Cryptic Pocket in CB1 Drives Peripheral and Functional Selectivity Nature 2025.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-025-08618-7