Fluorine in PDB 1agr: Complex of ALF4-Activated Gi-Alpha-1 with RGS4
Protein crystallography data
The structure of Complex of ALF4-Activated Gi-Alpha-1 with RGS4, PDB code: 1agr
was solved by
J.J.G.Tesmer,
S.R.Sprang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
5.00 /
2.80
|
|
Space group
|
P 21 21 2
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
164.000,
97.200,
110.000,
90.00,
90.00,
90.00
|
|
R / Rfree (%)
|
21.6 /
29.1
|
Other elements in 1agr:
The structure of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
(pdb code 1agr). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the
Complex of ALF4-Activated Gi-Alpha-1 with RGS4, PDB code: 1agr:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Fluorine binding site 1 out
of 8 in 1agr
Go back to
Fluorine Binding Sites List in 1agr
Fluorine binding site 1 out
of 8 in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F357
b:9.2
occ:1.00
|
F1
|
A:ALF357
|
0.0
|
9.2
|
1.0
|
|
AL
|
A:ALF357
|
1.8
|
12.3
|
1.0
|
|
O3B
|
A:GDP355
|
2.4
|
28.5
|
1.0
|
|
F4
|
A:ALF357
|
2.5
|
8.3
|
1.0
|
|
F2
|
A:ALF357
|
2.5
|
2.6
|
1.0
|
|
NH2
|
A:ARG178
|
2.5
|
11.1
|
1.0
|
|
O
|
A:HOH359A
|
2.7
|
22.2
|
1.0
|
|
N
|
A:GLU43
|
2.8
|
25.9
|
1.0
|
|
NE2
|
A:GLN204
|
3.0
|
2.4
|
1.0
|
|
CA
|
A:GLY42
|
3.5
|
19.1
|
1.0
|
|
CZ
|
A:ARG178
|
3.5
|
19.8
|
1.0
|
|
F3
|
A:ALF357
|
3.5
|
19.3
|
1.0
|
|
C
|
A:GLY42
|
3.5
|
21.6
|
1.0
|
|
NH1
|
A:ARG178
|
3.6
|
22.4
|
1.0
|
|
CA
|
A:GLU43
|
3.7
|
27.7
|
1.0
|
|
CD
|
A:GLN204
|
3.7
|
5.4
|
1.0
|
|
PB
|
A:GDP355
|
3.8
|
16.9
|
1.0
|
|
OE1
|
A:GLN204
|
3.8
|
8.7
|
1.0
|
|
CG
|
A:GLU43
|
3.9
|
39.2
|
1.0
|
|
O
|
A:HOH377
|
4.2
|
13.6
|
1.0
|
|
CG
|
A:LYS180
|
4.3
|
29.1
|
1.0
|
|
O1B
|
A:GDP355
|
4.3
|
7.8
|
1.0
|
|
CB
|
A:GLU43
|
4.4
|
28.4
|
1.0
|
|
O
|
A:GLY42
|
4.6
|
22.1
|
1.0
|
|
O3A
|
A:GDP355
|
4.6
|
11.5
|
1.0
|
|
O2B
|
A:GDP355
|
4.6
|
2.0
|
1.0
|
|
N
|
A:GLY203
|
4.7
|
12.0
|
1.0
|
|
N
|
A:THR181
|
4.7
|
21.3
|
1.0
|
|
NE
|
A:ARG178
|
4.7
|
21.4
|
1.0
|
|
CA
|
A:LYS180
|
4.7
|
19.4
|
1.0
|
|
CD
|
A:LYS180
|
4.7
|
34.1
|
1.0
|
|
O
|
A:HOH365
|
4.7
|
11.6
|
1.0
|
|
MG
|
A:MG356
|
4.8
|
14.3
|
1.0
|
|
N
|
A:GLY42
|
4.9
|
17.8
|
1.0
|
|
CB
|
A:LYS180
|
4.9
|
13.6
|
1.0
|
|
C
|
A:GLU43
|
5.0
|
26.6
|
1.0
|
|
NZ
|
A:LYS46
|
5.0
|
15.0
|
1.0
|
|
Fluorine binding site 2 out
of 8 in 1agr
Go back to
Fluorine Binding Sites List in 1agr
Fluorine binding site 2 out
of 8 in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F357
b:2.6
occ:1.00
|
F2
|
A:ALF357
|
0.0
|
2.6
|
1.0
|
|
AL
|
A:ALF357
|
1.8
|
12.3
|
1.0
|
|
F3
|
A:ALF357
|
2.4
|
19.3
|
1.0
|
|
O3B
|
A:GDP355
|
2.4
|
28.5
|
1.0
|
|
F1
|
A:ALF357
|
2.5
|
9.2
|
1.0
|
|
NH1
|
A:ARG178
|
2.5
|
22.4
|
1.0
|
|
O
|
A:HOH365
|
2.6
|
11.6
|
1.0
|
|
N
|
A:THR181
|
2.6
|
21.3
|
1.0
|
|
O
|
A:HOH359A
|
2.7
|
22.2
|
1.0
|
|
MG
|
A:MG356
|
3.0
|
14.3
|
1.0
|
|
NH2
|
A:ARG178
|
3.0
|
11.1
|
1.0
|
|
CA
|
A:LYS180
|
3.1
|
19.4
|
1.0
|
|
CZ
|
A:ARG178
|
3.2
|
19.8
|
1.0
|
|
C
|
A:LYS180
|
3.3
|
22.1
|
1.0
|
|
OG1
|
A:THR181
|
3.4
|
29.4
|
1.0
|
|
F4
|
A:ALF357
|
3.5
|
8.3
|
1.0
|
|
O2B
|
A:GDP355
|
3.6
|
2.0
|
1.0
|
|
PB
|
A:GDP355
|
3.6
|
16.9
|
1.0
|
|
CA
|
A:THR181
|
3.7
|
21.4
|
1.0
|
|
CB
|
A:THR181
|
3.7
|
26.5
|
1.0
|
|
O
|
A:VAL179
|
3.7
|
15.9
|
1.0
|
|
CG
|
A:LYS180
|
3.9
|
29.1
|
1.0
|
|
CB
|
A:LYS180
|
4.0
|
13.6
|
1.0
|
|
N
|
A:LYS180
|
4.1
|
18.3
|
1.0
|
|
O2A
|
A:GDP355
|
4.2
|
20.3
|
1.0
|
|
C
|
A:VAL179
|
4.3
|
13.8
|
1.0
|
|
O
|
A:THR181
|
4.3
|
17.8
|
1.0
|
|
O
|
A:LYS180
|
4.4
|
27.3
|
1.0
|
|
C
|
A:THR181
|
4.5
|
19.6
|
1.0
|
|
NE
|
A:ARG178
|
4.5
|
21.4
|
1.0
|
|
O
|
A:HOH364
|
4.6
|
15.1
|
1.0
|
|
O3A
|
A:GDP355
|
4.6
|
11.5
|
1.0
|
|
O1B
|
A:GDP355
|
4.8
|
7.8
|
1.0
|
|
OG
|
A:SER47
|
4.8
|
19.6
|
1.0
|
|
NE2
|
A:GLN204
|
4.8
|
2.4
|
1.0
|
|
N
|
A:GLU43
|
4.8
|
25.9
|
1.0
|
|
PA
|
A:GDP355
|
4.9
|
19.2
|
1.0
|
|
OE1
|
A:GLN204
|
5.0
|
8.7
|
1.0
|
|
CD
|
A:LYS180
|
5.0
|
34.1
|
1.0
|
|
Fluorine binding site 3 out
of 8 in 1agr
Go back to
Fluorine Binding Sites List in 1agr
Fluorine binding site 3 out
of 8 in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F357
b:19.3
occ:1.00
|
F3
|
A:ALF357
|
0.0
|
19.3
|
1.0
|
|
AL
|
A:ALF357
|
1.7
|
12.3
|
1.0
|
|
MG
|
A:MG356
|
2.0
|
14.3
|
1.0
|
|
F2
|
A:ALF357
|
2.4
|
2.6
|
1.0
|
|
F4
|
A:ALF357
|
2.4
|
8.3
|
1.0
|
|
O
|
A:HOH364
|
2.5
|
15.1
|
1.0
|
|
O
|
A:HOH359A
|
2.7
|
22.2
|
1.0
|
|
O3B
|
A:GDP355
|
2.8
|
28.5
|
1.0
|
|
O2B
|
A:GDP355
|
2.9
|
2.0
|
1.0
|
|
OG1
|
A:THR181
|
2.9
|
29.4
|
1.0
|
|
CB
|
A:THR181
|
3.0
|
26.5
|
1.0
|
|
PB
|
A:GDP355
|
3.2
|
16.9
|
1.0
|
|
O
|
A:HOH365
|
3.3
|
11.6
|
1.0
|
|
O
|
A:VAL201
|
3.4
|
29.0
|
1.0
|
|
F1
|
A:ALF357
|
3.5
|
9.2
|
1.0
|
|
N
|
A:THR181
|
3.6
|
21.3
|
1.0
|
|
O1B
|
A:GDP355
|
3.8
|
7.8
|
1.0
|
|
OG
|
A:SER47
|
3.8
|
19.6
|
1.0
|
|
CA
|
A:THR181
|
3.8
|
21.4
|
1.0
|
|
CA
|
A:GLY202
|
4.0
|
8.6
|
1.0
|
|
O
|
A:THR181
|
4.1
|
17.8
|
1.0
|
|
CE
|
A:LYS46
|
4.1
|
19.8
|
1.0
|
|
NZ
|
A:LYS46
|
4.1
|
15.0
|
1.0
|
|
N
|
A:GLY203
|
4.2
|
12.0
|
1.0
|
|
CG2
|
A:THR181
|
4.2
|
21.1
|
1.0
|
|
C
|
A:VAL201
|
4.3
|
23.5
|
1.0
|
|
C
|
A:THR181
|
4.4
|
19.6
|
1.0
|
|
C
|
A:GLY202
|
4.6
|
11.3
|
1.0
|
|
NH1
|
A:ARG178
|
4.6
|
22.4
|
1.0
|
|
N
|
A:GLY202
|
4.6
|
18.1
|
1.0
|
|
O3A
|
A:GDP355
|
4.7
|
11.5
|
1.0
|
|
C
|
A:LYS180
|
4.8
|
22.1
|
1.0
|
|
CB
|
A:SER47
|
5.0
|
24.8
|
1.0
|
|
Fluorine binding site 4 out
of 8 in 1agr
Go back to
Fluorine Binding Sites List in 1agr
Fluorine binding site 4 out
of 8 in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F357
b:8.3
occ:1.00
|
F4
|
A:ALF357
|
0.0
|
8.3
|
1.0
|
|
AL
|
A:ALF357
|
1.7
|
12.3
|
1.0
|
|
F3
|
A:ALF357
|
2.4
|
19.3
|
1.0
|
|
F1
|
A:ALF357
|
2.5
|
9.2
|
1.0
|
|
O
|
A:HOH359A
|
2.6
|
22.2
|
1.0
|
|
N
|
A:GLY203
|
2.7
|
12.0
|
1.0
|
|
NZ
|
A:LYS46
|
2.9
|
15.0
|
1.0
|
|
O3B
|
A:GDP355
|
2.9
|
28.5
|
1.0
|
|
CA
|
A:GLY203
|
3.2
|
12.1
|
1.0
|
|
CA
|
A:GLY42
|
3.2
|
19.1
|
1.0
|
|
F2
|
A:ALF357
|
3.5
|
2.6
|
1.0
|
|
O1B
|
A:GDP355
|
3.5
|
7.8
|
1.0
|
|
CE
|
A:LYS46
|
3.6
|
19.8
|
1.0
|
|
PB
|
A:GDP355
|
3.6
|
16.9
|
1.0
|
|
N
|
A:GLU43
|
3.6
|
25.9
|
1.0
|
|
C
|
A:GLY202
|
3.7
|
11.3
|
1.0
|
|
OE1
|
A:GLN204
|
3.9
|
8.7
|
1.0
|
|
CA
|
A:GLY202
|
3.9
|
8.6
|
1.0
|
|
C
|
A:GLY42
|
4.0
|
21.6
|
1.0
|
|
O
|
A:VAL201
|
4.1
|
29.0
|
1.0
|
|
O
|
A:ALA41
|
4.2
|
13.3
|
1.0
|
|
N
|
A:GLY42
|
4.2
|
17.8
|
1.0
|
|
O2B
|
A:GDP355
|
4.2
|
2.0
|
1.0
|
|
C
|
A:GLY203
|
4.3
|
15.0
|
1.0
|
|
MG
|
A:MG356
|
4.3
|
14.3
|
1.0
|
|
N
|
A:GLN204
|
4.3
|
13.9
|
1.0
|
|
NE2
|
A:GLN204
|
4.4
|
2.4
|
1.0
|
|
CD
|
A:GLN204
|
4.4
|
5.4
|
1.0
|
|
O
|
A:HOH364
|
4.5
|
15.1
|
1.0
|
|
C
|
A:ALA41
|
4.5
|
11.6
|
1.0
|
|
O
|
A:GLY202
|
4.7
|
14.2
|
1.0
|
|
CA
|
A:GLU43
|
4.8
|
27.7
|
1.0
|
|
NH2
|
A:ARG178
|
4.9
|
11.1
|
1.0
|
|
C
|
A:VAL201
|
4.9
|
23.5
|
1.0
|
|
O
|
A:THR181
|
4.9
|
17.8
|
1.0
|
|
O
|
A:GLY40
|
4.9
|
14.3
|
1.0
|
|
N
|
A:GLY202
|
4.9
|
18.1
|
1.0
|
|
Fluorine binding site 5 out
of 8 in 1agr
Go back to
Fluorine Binding Sites List in 1agr
Fluorine binding site 5 out
of 8 in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F357
b:22.4
occ:1.00
|
F1
|
D:ALF357
|
0.0
|
22.4
|
1.0
|
|
AL
|
D:ALF357
|
1.7
|
28.8
|
1.0
|
|
O3B
|
D:GDP355
|
2.3
|
31.5
|
1.0
|
|
F4
|
D:ALF357
|
2.5
|
18.6
|
1.0
|
|
F2
|
D:ALF357
|
2.5
|
14.2
|
1.0
|
|
NH2
|
D:ARG178
|
2.5
|
11.8
|
1.0
|
|
O
|
D:HOH360D
|
2.7
|
25.5
|
1.0
|
|
N
|
D:GLU43
|
2.8
|
23.5
|
1.0
|
|
NE2
|
D:GLN204
|
3.0
|
17.3
|
1.0
|
|
CZ
|
D:ARG178
|
3.4
|
18.1
|
1.0
|
|
F3
|
D:ALF357
|
3.5
|
21.1
|
1.0
|
|
CA
|
D:GLY42
|
3.5
|
22.9
|
1.0
|
|
C
|
D:GLY42
|
3.6
|
20.2
|
1.0
|
|
NH1
|
D:ARG178
|
3.6
|
15.3
|
1.0
|
|
CA
|
D:GLU43
|
3.7
|
28.3
|
1.0
|
|
PB
|
D:GDP355
|
3.8
|
27.5
|
1.0
|
|
CD
|
D:GLN204
|
3.8
|
10.6
|
1.0
|
|
OE1
|
D:GLN204
|
3.8
|
15.8
|
1.0
|
|
CG
|
D:GLU43
|
3.9
|
43.1
|
1.0
|
|
O
|
D:HOH378
|
4.1
|
26.9
|
1.0
|
|
CG
|
D:LYS180
|
4.3
|
25.0
|
1.0
|
|
O1B
|
D:GDP355
|
4.3
|
17.7
|
1.0
|
|
CB
|
D:GLU43
|
4.4
|
28.1
|
1.0
|
|
O3A
|
D:GDP355
|
4.5
|
19.4
|
1.0
|
|
N
|
D:THR181
|
4.6
|
26.9
|
1.0
|
|
CA
|
D:LYS180
|
4.6
|
17.3
|
1.0
|
|
NE
|
D:ARG178
|
4.6
|
13.9
|
1.0
|
|
O
|
D:GLY42
|
4.6
|
17.7
|
1.0
|
|
O2B
|
D:GDP355
|
4.7
|
17.7
|
1.0
|
|
CD
|
D:LYS180
|
4.7
|
25.9
|
1.0
|
|
N
|
D:GLY203
|
4.7
|
22.9
|
1.0
|
|
O
|
D:HOH366
|
4.7
|
14.5
|
1.0
|
|
MG
|
D:MG356
|
4.8
|
15.2
|
1.0
|
|
CB
|
D:LYS180
|
4.9
|
10.9
|
1.0
|
|
N
|
D:GLY42
|
5.0
|
23.1
|
1.0
|
|
C
|
D:GLU43
|
5.0
|
31.1
|
1.0
|
|
Fluorine binding site 6 out
of 8 in 1agr
Go back to
Fluorine Binding Sites List in 1agr
Fluorine binding site 6 out
of 8 in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F357
b:14.2
occ:1.00
|
F2
|
D:ALF357
|
0.0
|
14.2
|
1.0
|
|
AL
|
D:ALF357
|
1.8
|
28.8
|
1.0
|
|
F3
|
D:ALF357
|
2.3
|
21.1
|
1.0
|
|
O3B
|
D:GDP355
|
2.4
|
31.5
|
1.0
|
|
F1
|
D:ALF357
|
2.5
|
22.4
|
1.0
|
|
NH1
|
D:ARG178
|
2.5
|
15.3
|
1.0
|
|
O
|
D:HOH366
|
2.6
|
14.5
|
1.0
|
|
N
|
D:THR181
|
2.6
|
26.9
|
1.0
|
|
O
|
D:HOH360D
|
2.7
|
25.5
|
1.0
|
|
MG
|
D:MG356
|
3.0
|
15.2
|
1.0
|
|
NH2
|
D:ARG178
|
3.0
|
11.8
|
1.0
|
|
CA
|
D:LYS180
|
3.1
|
17.3
|
1.0
|
|
CZ
|
D:ARG178
|
3.2
|
18.1
|
1.0
|
|
C
|
D:LYS180
|
3.3
|
24.4
|
1.0
|
|
OG1
|
D:THR181
|
3.4
|
42.7
|
1.0
|
|
F4
|
D:ALF357
|
3.5
|
18.6
|
1.0
|
|
PB
|
D:GDP355
|
3.6
|
27.5
|
1.0
|
|
O2B
|
D:GDP355
|
3.6
|
17.7
|
1.0
|
|
CA
|
D:THR181
|
3.7
|
30.9
|
1.0
|
|
CB
|
D:THR181
|
3.7
|
37.7
|
1.0
|
|
O
|
D:VAL179
|
3.7
|
20.4
|
1.0
|
|
CG
|
D:LYS180
|
4.0
|
25.0
|
1.0
|
|
N
|
D:LYS180
|
4.1
|
17.9
|
1.0
|
|
CB
|
D:LYS180
|
4.1
|
10.9
|
1.0
|
|
O2A
|
D:GDP355
|
4.1
|
30.6
|
1.0
|
|
C
|
D:VAL179
|
4.3
|
16.2
|
1.0
|
|
O
|
D:THR181
|
4.3
|
21.7
|
1.0
|
|
O3A
|
D:GDP355
|
4.4
|
19.4
|
1.0
|
|
O
|
D:LYS180
|
4.4
|
34.3
|
1.0
|
|
NE
|
D:ARG178
|
4.5
|
13.9
|
1.0
|
|
C
|
D:THR181
|
4.5
|
28.3
|
1.0
|
|
O
|
D:HOH365
|
4.5
|
18.9
|
1.0
|
|
O1B
|
D:GDP355
|
4.7
|
17.7
|
1.0
|
|
OG
|
D:SER47
|
4.7
|
24.1
|
1.0
|
|
N
|
D:GLU43
|
4.8
|
23.5
|
1.0
|
|
PA
|
D:GDP355
|
4.8
|
21.4
|
1.0
|
|
NE2
|
D:GLN204
|
4.8
|
17.3
|
1.0
|
|
Fluorine binding site 7 out
of 8 in 1agr
Go back to
Fluorine Binding Sites List in 1agr
Fluorine binding site 7 out
of 8 in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F357
b:21.1
occ:1.00
|
F3
|
D:ALF357
|
0.0
|
21.1
|
1.0
|
|
AL
|
D:ALF357
|
1.7
|
28.8
|
1.0
|
|
MG
|
D:MG356
|
2.0
|
15.2
|
1.0
|
|
F2
|
D:ALF357
|
2.3
|
14.2
|
1.0
|
|
O
|
D:HOH365
|
2.5
|
18.9
|
1.0
|
|
F4
|
D:ALF357
|
2.5
|
18.6
|
1.0
|
|
O3B
|
D:GDP355
|
2.7
|
31.5
|
1.0
|
|
O
|
D:HOH360D
|
2.8
|
25.5
|
1.0
|
|
O2B
|
D:GDP355
|
2.9
|
17.7
|
1.0
|
|
OG1
|
D:THR181
|
2.9
|
42.7
|
1.0
|
|
CB
|
D:THR181
|
3.0
|
37.7
|
1.0
|
|
PB
|
D:GDP355
|
3.1
|
27.5
|
1.0
|
|
O
|
D:HOH366
|
3.3
|
14.5
|
1.0
|
|
F1
|
D:ALF357
|
3.5
|
22.4
|
1.0
|
|
O
|
D:VAL201
|
3.5
|
39.4
|
1.0
|
|
N
|
D:THR181
|
3.6
|
26.9
|
1.0
|
|
O1B
|
D:GDP355
|
3.8
|
17.7
|
1.0
|
|
OG
|
D:SER47
|
3.8
|
24.1
|
1.0
|
|
CA
|
D:THR181
|
3.8
|
30.9
|
1.0
|
|
CA
|
D:GLY202
|
4.1
|
21.7
|
1.0
|
|
O
|
D:THR181
|
4.1
|
21.7
|
1.0
|
|
CE
|
D:LYS46
|
4.1
|
34.7
|
1.0
|
|
NZ
|
D:LYS46
|
4.2
|
32.9
|
1.0
|
|
CG2
|
D:THR181
|
4.2
|
34.5
|
1.0
|
|
N
|
D:GLY203
|
4.3
|
22.9
|
1.0
|
|
C
|
D:VAL201
|
4.4
|
33.5
|
1.0
|
|
C
|
D:THR181
|
4.4
|
28.3
|
1.0
|
|
NH1
|
D:ARG178
|
4.6
|
15.3
|
1.0
|
|
O3A
|
D:GDP355
|
4.6
|
19.4
|
1.0
|
|
C
|
D:GLY202
|
4.6
|
22.7
|
1.0
|
|
N
|
D:GLY202
|
4.7
|
29.7
|
1.0
|
|
C
|
D:LYS180
|
4.8
|
24.4
|
1.0
|
|
CB
|
D:SER47
|
4.9
|
32.6
|
1.0
|
|
Fluorine binding site 8 out
of 8 in 1agr
Go back to
Fluorine Binding Sites List in 1agr
Fluorine binding site 8 out
of 8 in the Complex of ALF4-Activated Gi-Alpha-1 with RGS4
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Complex of ALF4-Activated Gi-Alpha-1 with RGS4 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F357
b:18.6
occ:1.00
|
F4
|
D:ALF357
|
0.0
|
18.6
|
1.0
|
|
AL
|
D:ALF357
|
1.7
|
28.8
|
1.0
|
|
F1
|
D:ALF357
|
2.5
|
22.4
|
1.0
|
|
F3
|
D:ALF357
|
2.5
|
21.1
|
1.0
|
|
O
|
D:HOH360D
|
2.6
|
25.5
|
1.0
|
|
N
|
D:GLY203
|
2.7
|
22.9
|
1.0
|
|
O3B
|
D:GDP355
|
2.9
|
31.5
|
1.0
|
|
NZ
|
D:LYS46
|
2.9
|
32.9
|
1.0
|
|
CA
|
D:GLY42
|
3.2
|
22.9
|
1.0
|
|
CA
|
D:GLY203
|
3.2
|
18.9
|
1.0
|
|
O1B
|
D:GDP355
|
3.5
|
17.7
|
1.0
|
|
F2
|
D:ALF357
|
3.5
|
14.2
|
1.0
|
|
N
|
D:GLU43
|
3.6
|
23.5
|
1.0
|
|
PB
|
D:GDP355
|
3.6
|
27.5
|
1.0
|
|
CE
|
D:LYS46
|
3.6
|
34.7
|
1.0
|
|
C
|
D:GLY202
|
3.7
|
22.7
|
1.0
|
|
OE1
|
D:GLN204
|
3.9
|
15.8
|
1.0
|
|
C
|
D:GLY42
|
3.9
|
20.2
|
1.0
|
|
CA
|
D:GLY202
|
4.0
|
21.7
|
1.0
|
|
O
|
D:ALA41
|
4.1
|
22.0
|
1.0
|
|
O
|
D:VAL201
|
4.1
|
39.4
|
1.0
|
|
N
|
D:GLY42
|
4.2
|
23.1
|
1.0
|
|
C
|
D:GLY203
|
4.3
|
19.1
|
1.0
|
|
O2B
|
D:GDP355
|
4.3
|
17.7
|
1.0
|
|
N
|
D:GLN204
|
4.3
|
20.3
|
1.0
|
|
MG
|
D:MG356
|
4.4
|
15.2
|
1.0
|
|
NE2
|
D:GLN204
|
4.4
|
17.3
|
1.0
|
|
CD
|
D:GLN204
|
4.4
|
10.6
|
1.0
|
|
C
|
D:ALA41
|
4.5
|
19.0
|
1.0
|
|
O
|
D:HOH365
|
4.5
|
18.9
|
1.0
|
|
O
|
D:GLY202
|
4.7
|
24.1
|
1.0
|
|
CA
|
D:GLU43
|
4.8
|
28.3
|
1.0
|
|
O
|
D:GLY40
|
4.9
|
22.6
|
1.0
|
|
NH2
|
D:ARG178
|
4.9
|
11.8
|
1.0
|
|
O
|
D:THR181
|
4.9
|
21.7
|
1.0
|
|
C
|
D:VAL201
|
5.0
|
33.5
|
1.0
|
|
N
|
D:GLY202
|
5.0
|
29.7
|
1.0
|
|
Reference:
J.J.Tesmer,
D.M.Berman,
A.G.Gilman,
S.R.Sprang.
Structure of RGS4 Bound to ALF4--Activated G(I ALPHA1): Stabilization of the Transition State For Gtp Hydrolysis. Cell(Cambridge,Mass.) V. 89 251 1997.
ISSN: ISSN 0092-8674
PubMed: 9108480
DOI: 10.1016/S0092-8674(00)80204-4
Page generated: Sun Dec 13 11:28:10 2020
|
