Fluorine in PDB 1dxw: Structure of Hetero Complex of Non Structural Protein (Ns) of Hepatitis C Virus (Hcv) and Synthetic Peptidic Compound

The structure of Structure of Hetero Complex of Non Structural Protein (Ns) of Hepatitis C Virus (Hcv) and Synthetic Peptidic Compound also contains other interesting chemical elements:

Zinc

(Zn)

20 atoms

The binding sites of Fluorine atom in the Structure of Hetero Complex of Non Structural Protein (Ns) of Hepatitis C Virus (Hcv) and Synthetic Peptidic Compound (pdb code 1dxw). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of Hetero Complex of Non Structural Protein (Ns) of Hepatitis C Virus (Hcv) and Synthetic Peptidic Compound, PDB code: 1dxw:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Structure of Hetero Complex of Non Structural Protein (Ns) of Hepatitis C Virus (Hcv) and Synthetic Peptidic Compound


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Hetero Complex of Non Structural Protein (Ns) of Hepatitis C Virus (Hcv) and Synthetic Peptidic Compound within 5.0Å range: probe atom residue distance (Å) B Occ A:F188 b:0.0 occ:1.00 F1 A:2ZF188 0.0 0.0 1.0 CG2 A:2ZF188 1.4 0.0 1.0 HG1 A:2ZF188 2.0 0.0 1.0 HD3 A:LYS136 2.2 0.0 1.0 HA A:LYS136 2.2 0.0 1.0 HA2 A:2ZF188 2.3 0.0 1.0 F2 A:2ZF188 2.3 0.0 1.0 CB2 A:2ZF188 2.4 0.0 1.0 HZ1 A:LYS136 2.5 0.0 1.0 HZ3 A:LYS136 2.6 0.0 1.0 HB1 A:2ZF188 2.7 0.0 1.0 CA2 A:2ZF188 2.8 0.0 1.0 NZ A:LYS136 3.0 0.0 1.0 CD A:LYS136 3.2 0.0 1.0 CA A:LYS136 3.3 0.0 1.0 HB22 A:2ZF188 3.3 0.0 1.0 O A:LEU135 3.4 0.0 1.0 H A:GLY137 3.4 0.0 1.0 HG2 A:LYS136 3.5 0.0 1.0 O3 A:2ZF188 3.6 0.0 1.0 N A:LYS136 3.7 0.0 1.0 C A:LEU135 3.7 0.0 1.0 OE11 A:2ZF188 3.7 0.0 1.0 CG A:LYS136 3.8 0.0 1.0 CE A:LYS136 3.8 0.0 1.0 N2 A:2ZF188 3.8 0.0 1.0 HG21 A:VAL132 3.8 0.0 1.0 HZ2 A:LYS136 3.9 0.0 1.0 HD2 A:LYS136 4.0 0.0 1.0 C6 A:2ZF188 4.0 0.0 1.0 C5 A:2ZF188 4.0 0.0 1.0 CB A:LYS136 4.1 0.0 1.0 CD3 A:2ZF188 4.1 0.0 1.0 N A:GLY137 4.2 0.0 1.0 O A:VAL132 4.3 0.0 1.0 HB2 A:ALA157 4.3 0.0 1.0 C A:LYS136 4.3 0.0 1.0 HB2 A:LEU135 4.3 0.0 1.0 H A:LYS136 4.3 0.0 1.0 HE3 A:LYS136 4.4 0.0 1.0 HG A:SER138 4.4 0.0 1.0 HB3 A:LYS136 4.4 0.0 1.0 HE2 A:PHE154 4.5 0.0 1.0 H14 A:2ZF188 4.5 0.0 1.0 HE2 A:LYS136 4.5 0.0 1.0 OG A:SER139 4.6 0.0 1.0 HB3 A:LEU135 4.6 0.0 1.0 H A:SER138 4.7 0.0 1.0 O A:2ZF188 4.7 0.0 1.0 CG2 A:VAL132 4.7 0.0 1.0 HG3 A:LYS136 4.8 0.0 1.0 CB A:LEU135 4.8 0.0 1.0 CA A:LEU135 4.9 0.0 1.0 HG22 A:VAL132 4.9 0.0 1.0 HG23 A:VAL132 4.9 0.0 1.0 HB1 A:ALA157 4.9 0.0 1.0

Fluorine binding site 2 out of 2 in the Structure of Hetero Complex of Non Structural Protein (Ns) of Hepatitis C Virus (Hcv) and Synthetic Peptidic Compound


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Hetero Complex of Non Structural Protein (Ns) of Hepatitis C Virus (Hcv) and Synthetic Peptidic Compound within 5.0Å range: probe atom residue distance (Å) B Occ A:F188 b:0.0 occ:1.00 F2 A:2ZF188 0.0 0.0 1.0 CG2 A:2ZF188 1.3 0.0 1.0 HG1 A:2ZF188 1.6 0.0 1.0 HB2 A:ALA157 2.2 0.0 1.0 F1 A:2ZF188 2.3 0.0 1.0 CB2 A:2ZF188 2.5 0.0 1.0 HB22 A:2ZF188 2.7 0.0 1.0 O A:2ZF188 2.8 0.0 1.0 HB1 A:ALA157 2.9 0.0 1.0 H A:ALA157 2.9 0.0 1.0 CB A:ALA157 3.0 0.0 1.0 CA2 A:2ZF188 3.3 0.0 1.0 HA2 A:2ZF188 3.3 0.0 1.0 HB1 A:2ZF188 3.3 0.0 1.0 HZ1 A:LYS136 3.3 0.0 1.0 HG21 A:VAL132 3.4 0.0 1.0 HZ3 A:LYS136 3.4 0.0 1.0 N2 A:2ZF188 3.4 0.0 1.0 O3 A:2ZF188 3.5 0.0 1.0 HG22 A:VAL132 3.5 0.0 1.0 C5 A:2ZF188 3.5 0.0 1.0 N A:ALA157 3.6 0.0 1.0 HE2 A:PHE154 3.7 0.0 1.0 HB3 A:ALA157 3.7 0.0 1.0 C4 A:2ZF188 3.8 0.0 1.0 NZ A:LYS136 3.8 0.0 1.0 CG2 A:VAL132 3.8 0.0 1.0 HB2 A:2ZF188 3.9 0.0 1.0 H14 A:2ZF188 3.9 0.0 1.0 CA A:ALA157 4.0 0.0 1.0 HZ A:PHE154 4.0 0.0 1.0 HB3 A:2ZF188 4.0 0.0 1.0 HA A:ALA156 4.0 0.0 1.0 HG23 A:VAL132 4.0 0.0 1.0 HB2 A:LEU135 4.1 0.0 1.0 HZ2 A:LYS136 4.2 0.0 1.0 HB3 A:LEU135 4.3 0.0 1.0 HD3 A:LYS136 4.3 0.0 1.0 CB A:2ZF188 4.3 0.0 1.0 HA A:LYS136 4.4 0.0 1.0 CE2 A:PHE154 4.4 0.0 1.0 O A:LEU135 4.4 0.0 1.0 CA1 A:2ZF188 4.5 0.0 1.0 N1 A:2ZF188 4.5 0.0 1.0 C A:ALA156 4.6 0.0 1.0 CZ A:PHE154 4.6 0.0 1.0 HA1 A:2ZF188 4.6 0.0 1.0 CA A:2ZF188 4.7 0.0 1.0 CB A:LEU135 4.7 0.0 1.0 HN2 A:2ZF188 4.7 0.0 1.0 HA A:ALA157 4.7 0.0 1.0 C6 A:2ZF188 4.7 0.0 1.0 O A:VAL132 4.8 0.0 1.0 HG A:SER138 4.8 0.0 1.0 CA A:ALA156 4.8 0.0 1.0 C A:LEU135 4.9 0.0 1.0 O A:ALA157 4.9 0.0 1.0 C A:ALA157 4.9 0.0 1.0

G.Barbato, D.O.Cicero, F.Cordier, F.Narjes, B.Gerlach, S.Sambucini, S.Grzesiek, V.G.Matassa, R.Defrancesco, R.Bazzo. Inhibitor Binding Induces Active Site Stabilisation of the Hcv NS3 Protein Serine Protease Domain Embo J. V. 19 1195 2000.
ISSN: ISSN 0261-4189
PubMed: 10716920
DOI: 10.1093/EMBOJ/19.6.1195