Fluorine in PDB 1fuy: Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate

Enzymatic activity of Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate

All present enzymatic activity of Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate:
4.2.1.20;

Protein crystallography data

The structure of Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate, PDB code: 1fuy was solved by M.Weyand, I.Schlichting, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 2.25
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	184.000, 60.700, 67.400, 90.00, 95.75, 90.00
*R / R_free (%)*	17 / 22.4

Other elements in 1fuy:

The structure of Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate also contains other interesting chemical elements:

Sodium

(Na)

1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate (pdb code 1fuy). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate, PDB code: 1fuy:

Fluorine binding site 1 out of 1 in 1fuy

Go back to

Fluorine Binding Sites List in 1fuy

Fluorine binding site 1 out of 1 in the Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate

Mono view

Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of BETAA169L/BETAC170W Double Mutant of Tryptophan Synthase Complexed with 5-Fluoro-Indole-Propanol Phosphate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:F269 b:44.1 occ:1.00	F	A:FIP269	0.0	44.1	1.0
	C5	A:FIP269	1.3	42.2	1.0
	C6	A:FIP269	2.3	40.0	1.0
	C4	A:FIP269	2.4	39.8	1.0
	CD1	A:ILE153	3.2	31.7	1.0
	C7	A:FIP269	3.6	39.6	1.0
	C9	A:FIP269	3.6	38.9	1.0
	CE1	A:PHE212	3.7	48.4	1.0
	CZ	A:PHE212	3.8	48.2	1.0
	C8	A:FIP269	4.0	38.0	1.0
	O	B:HOH474	4.1	43.1	1.0
	CG1	A:ILE153	4.3	32.4	1.0
	CB	A:ALA129	4.5	20.9	1.0
	CD2	A:LEU100	4.5	30.9	1.0
	CE1	A:TYR175	4.6	34.9	1.0
	OH	A:TYR175	4.7	36.1	1.0
	CZ	A:TYR175	4.7	36.0	1.0
	CD1	A:PHE212	4.8	47.5	1.0
	CD1	A:LEU127	4.9	29.8	1.0
	CE2	A:PHE212	4.9	47.9	1.0
	CD2	A:LEU127	4.9	31.3	1.0
	CD1	A:LEU177	4.9	43.8	1.0
	C3	A:FIP269	5.0	39.0	1.0

Reference:

M.Weyand, I.Schlichting. Structural Basis For the Impaired Channeling and Allosteric Inter-Subunit Communication in the Beta A169L/Beta C170W Mutant of Tryptophan Synthase. J.Biol.Chem. V. 275 41058 2000.
ISSN: ISSN 0021-9258
PubMed: 11034989
DOI: 10.1074/JBC.C000479200

Page generated: Sun Dec 13 11:29:36 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy