Fluorine in PDB 1gs4: Structural Basis For the Glucocorticoid Response in A Mutant Human Androgen Receptor (Arccr) Derived From An Androgen-Independent Prostate Cancer

The structure of Structural Basis For the Glucocorticoid Response in A Mutant Human Androgen Receptor (Arccr) Derived From An Androgen-Independent Prostate Cancer, PDB code: 1gs4 was solved by P.M.Matias, M.A.Carrondo, R.Coelho, M.Thomaz, X.-Y.Zhao, A.Wegg, K.Crusius, U.Egner, P.Donner, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	21.50 / 1.95
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.350, 66.230, 73.050, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 28.5

The binding sites of Fluorine atom in the Structural Basis For the Glucocorticoid Response in A Mutant Human Androgen Receptor (Arccr) Derived From An Androgen-Independent Prostate Cancer (pdb code 1gs4). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structural Basis For the Glucocorticoid Response in A Mutant Human Androgen Receptor (Arccr) Derived From An Androgen-Independent Prostate Cancer, PDB code: 1gs4:

Fluorine binding site 1 out of 1 in the Structural Basis For the Glucocorticoid Response in A Mutant Human Androgen Receptor (Arccr) Derived From An Androgen-Independent Prostate Cancer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structural Basis For the Glucocorticoid Response in A Mutant Human Androgen Receptor (Arccr) Derived From An Androgen-Independent Prostate Cancer within 5.0Å range: probe atom residue distance (Å) B Occ A:F1918 b:25.9 occ:1.00 F9 A:ZK51918 0.0 25.9 1.0 C9 A:ZK51918 1.4 29.4 1.0 C11 A:ZK51918 2.3 26.9 1.0 C8 A:ZK51918 2.3 29.1 1.0 C10 A:ZK51918 2.4 26.2 1.0 C14 A:ZK51918 2.7 33.4 1.0 C1 A:ZK51918 2.8 31.2 1.0 C7 A:ZK51918 2.8 21.6 1.0 C5 A:ZK51918 2.9 23.3 1.0 C12 A:ZK51918 2.9 29.9 1.0 CB A:LEU704 3.4 18.8 1.0 C6 A:ZK51918 3.4 24.3 1.0 C13 A:ZK51918 3.4 35.8 1.0 CD2 A:LEU704 3.5 25.1 1.0 O2 A:ZK51918 3.6 27.5 1.0 C4 A:ZK51918 3.7 25.7 1.0 C19 A:ZK51918 3.8 30.5 1.0 CG A:LEU704 3.8 27.7 1.0 O A:LEU704 3.9 23.8 1.0 C2 A:ZK51918 4.0 27.2 1.0 CD1 A:LEU704 4.1 23.0 1.0 C15 A:ZK51918 4.1 31.5 1.0 C3 A:ZK51918 4.1 27.8 1.0 O3 A:ZK51918 4.2 31.4 1.0 CA A:LEU704 4.2 24.8 1.0 C A:LEU704 4.3 24.9 1.0 CE2 A:PHE764 4.3 26.5 1.0 CD2 A:PHE764 4.4 23.0 1.0 C17 A:ZK51918 4.4 31.0 1.0 C18 A:ZK51918 4.5 26.8 1.0 C16 A:ZK51918 5.0 30.1 1.0

P.M.Matias, M.A.Carrondo, R.Coelho, M.Thomaz, X.-Y.Zhao, A.Wegg, K.Crusius, U.Egner, P.Donner. Structural Basis For the Glucocorticoid Response in A Mutant Human Androgen Receptor (Ar(Ccr)) Derived From An Androgen-Independent Prostate Cancer J.Med.Chem. V. 45 1439 2002.
ISSN: ISSN 0022-2623
PubMed: 11906285
DOI: 10.1021/JM011072J