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Fluorine in PDB 1h5u: The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug

Enzymatic activity of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug

All present enzymatic activity of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug:
2.4.1.1;

Protein crystallography data

The structure of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug, PDB code: 1h5u was solved by N.G.Oikonomakos, S.E.Zographos, V.T.Skamnaki, G.Archontis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 26.25 / 1.76
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 128.966, 128.966, 116.186, 90.00, 90.00, 90.00
R / Rfree (%) 21.1 / 23.5

Other elements in 1h5u:

The structure of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug (pdb code 1h5u). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug, PDB code: 1h5u:

Fluorine binding site 1 out of 1 in 1h5u

Go back to Fluorine Binding Sites List in 1h5u
Fluorine binding site 1 out of 1 in the The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose and CP320626, A Potential Antidiabetic Drug within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F920

b:32.3
occ:1.00
F1 A:CHI920 0.0 32.3 1.0
C21 A:CHI920 1.3 27.9 1.0
C22 A:CHI920 2.4 26.9 1.0
C20 A:CHI920 2.4 25.8 1.0
C23 A:CHI920 3.7 24.2 1.0
C19 A:CHI920 3.7 23.0 1.0
C18 A:CHI920 4.2 24.7 1.0
C15 A:CHI920 4.6 34.4 1.0
C14 A:CHI920 4.8 35.1 1.0

Reference:

N.G.Oikonomakos, S.E.Zographos, V.T.Skamnaki, G.Archontis. The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose, and CP320626, A Potential Antidiabetic Drug Bioorg.Med.Chem. V. 10 1313 2002.
ISSN: ISSN 0968-0896
PubMed: 11886794
DOI: 10.1016/S0968-0896(01)00394-7
Page generated: Sun Dec 13 11:29:59 2020

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