Fluorine in PDB 1m2z: Crystal Structure of A Dimer Complex of the Human Glucocorticoid Receptor Ligand-Binding Domain Bound to Dexamethasone and A TIF2 Coactivator Motif

The structure of Crystal Structure of A Dimer Complex of the Human Glucocorticoid Receptor Ligand-Binding Domain Bound to Dexamethasone and A TIF2 Coactivator Motif, PDB code: 1m2z was solved by R.B.Bledsoe, V.G.Montana, T.B.Stanley, C.J.Delves, C.J.Apolito, D.D.Mckee, T.G.Consler, D.J.Parks, E.L.Stewart, T.M.Willson, M.H.Lambert, J.T.Moore, K.H.Pearce, H.E.Xu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	8.00 / 2.50
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	125.843, 125.843, 85.976, 90.00, 90.00, 120.00
R / Rfree (%)	n/a / n/a

The binding sites of Fluorine atom in the Crystal Structure of A Dimer Complex of the Human Glucocorticoid Receptor Ligand-Binding Domain Bound to Dexamethasone and A TIF2 Coactivator Motif (pdb code 1m2z). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of A Dimer Complex of the Human Glucocorticoid Receptor Ligand-Binding Domain Bound to Dexamethasone and A TIF2 Coactivator Motif, PDB code: 1m2z:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Crystal Structure of A Dimer Complex of the Human Glucocorticoid Receptor Ligand-Binding Domain Bound to Dexamethasone and A TIF2 Coactivator Motif


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of A Dimer Complex of the Human Glucocorticoid Receptor Ligand-Binding Domain Bound to Dexamethasone and A TIF2 Coactivator Motif within 5.0Å range: probe atom residue distance (Å) B Occ A:F301 b:55.4 occ:1.00 F1 A:DEX301 0.0 55.4 1.0 C9 A:DEX301 1.4 52.3 1.0 C11 A:DEX301 2.2 52.5 1.0 C8 A:DEX301 2.3 52.7 1.0 C10 A:DEX301 2.3 50.6 1.0 H14 A:DEX301 2.4 52.8 1.0 C1 A:DEX301 2.7 48.5 1.0 C5 A:DEX301 2.8 49.4 1.0 C7 A:DEX301 2.9 50.8 1.0 C14 A:DEX301 2.9 52.2 1.0 C12 A:DEX301 2.9 51.7 1.0 CE2 A:PHE623 3.1 48.0 1.0 C6 A:DEX301 3.4 50.6 1.0 C2 A:DEX301 3.5 52.2 1.0 C4 A:DEX301 3.5 52.9 1.0 O2 A:DEX301 3.5 53.5 1.0 C13 A:DEX301 3.5 53.5 1.0 C19 A:DEX301 3.7 51.0 1.0 CD2 A:PHE623 3.8 45.9 1.0 C3 A:DEX301 3.9 52.6 1.0 CZ A:PHE623 4.1 47.7 1.0 C15 A:DEX301 4.3 52.5 1.0 CB A:LEU563 4.3 58.2 1.0 O3 A:DEX301 4.4 53.9 1.0 CD1 A:LEU563 4.5 54.6 1.0 SD A:MET646 4.5 66.6 1.0 C18 A:DEX301 4.5 53.1 1.0 C17 A:DEX301 4.6 54.6 1.0 O A:LEU563 4.8 57.1 1.0 CE A:MET646 4.9 65.5 1.0 O1 A:DEX301 5.0 62.7 1.0 CG A:LEU563 5.0 57.4 1.0

Fluorine binding site 2 out of 2 in the Crystal Structure of A Dimer Complex of the Human Glucocorticoid Receptor Ligand-Binding Domain Bound to Dexamethasone and A TIF2 Coactivator Motif


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of A Dimer Complex of the Human Glucocorticoid Receptor Ligand-Binding Domain Bound to Dexamethasone and A TIF2 Coactivator Motif within 5.0Å range: probe atom residue distance (Å) B Occ D:F401 b:58.7 occ:1.00 F1 D:DEX401 0.0 58.7 1.0 C9 D:DEX401 1.4 55.0 1.0 C11 D:DEX401 2.2 57.7 1.0 C8 D:DEX401 2.3 54.3 1.0 C10 D:DEX401 2.3 55.4 1.0 C1 D:DEX401 2.7 53.8 1.0 C5 D:DEX401 2.8 52.4 1.0 C7 D:DEX401 2.9 53.2 1.0 C14 D:DEX401 2.9 54.7 1.0 C12 D:DEX401 2.9 57.2 1.0 CE1 D:PHE623 3.2 51.9 1.0 C6 D:DEX401 3.4 51.0 1.0 C2 D:DEX401 3.5 55.4 1.0 C4 D:DEX401 3.5 54.5 1.0 O2 D:DEX401 3.5 58.4 1.0 C13 D:DEX401 3.5 56.2 1.0 C19 D:DEX401 3.7 57.7 1.0 CD1 D:PHE623 3.9 51.6 1.0 C3 D:DEX401 3.9 54.9 1.0 C15 D:DEX401 4.3 54.6 1.0 CZ D:PHE623 4.3 50.5 1.0 CB D:LEU563 4.3 57.4 1.0 SD D:MET646 4.4 65.5 1.0 O3 D:DEX401 4.4 54.0 1.0 CD1 D:LEU563 4.5 48.9 1.0 C18 D:DEX401 4.6 59.2 1.0 C17 D:DEX401 4.6 56.6 1.0 CE D:MET646 4.6 65.7 1.0 O1 D:DEX401 5.0 60.2 1.0 CG D:LEU563 5.0 55.4 1.0

R.B.Bledsoe, V.G.Montana, T.B.Stanley, C.J.Delves, C.J.Apolito, D.D.Mckee, T.G.Consler, D.J.Parks, E.L.Stewart, T.M.Willson, M.H.Lambert, J.T.Moore, K.H.Pearce, H.E.Xu. Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals A Novel Mode of Receptor Dimerization and Coactivator Recognition Cell(Cambridge,Mass.) V. 110 93 2002.
ISSN: ISSN 0092-8674
PubMed: 12151000
DOI: 10.1016/S0092-8674(02)00817-6