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Fluorine in PDB 1pxh: Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2
Enzymatic activity of Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2
All present enzymatic activity of Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2:
3.1.3.48;
3.1.3.48;
Protein crystallography data
The structure of Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2, PDB code: 1pxh
was solved by
J.P.Sun,
A.Fedorov,
S.Y.Lee,
X.L.Guo,
K.Shen,
D.S.Lawrence,
S.C.Almo,
Z.Y.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.15 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 52.840, 85.678, 88.678, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20 / 20.7 |
Other elements in 1pxh:
The structure of Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2 also contains other interesting chemical elements:
| Magnesium | (Mg) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2
(pdb code 1pxh). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2, PDB code: 1pxh:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2, PDB code: 1pxh:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 1pxh
Go back to
Fluorine Binding Sites List in 1pxh
Fluorine binding site 1 out
of 4 in the Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2 within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 1pxh
Go back to
Fluorine Binding Sites List in 1pxh
Fluorine binding site 2 out
of 4 in the Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2 within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 1pxh
Go back to
Fluorine Binding Sites List in 1pxh
Fluorine binding site 3 out
of 4 in the Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2 within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 1pxh
Go back to
Fluorine Binding Sites List in 1pxh
Fluorine binding site 4 out
of 4 in the Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Protein Tyrosine Phosphatase 1B with Potent and Selective Bidentate Inhibitor Compound 2 within 5.0Å range:
|
Reference:
J.P.Sun,
A.A.Fedorov,
S.Y.Lee,
X.L.Guo,
K.Shen,
D.S.Lawrence,
S.C.Almo,
Z.Y.Zhang.
Crystal Structure of PTP1B Complexed with A Potent and Selective Bidentate Inhibitor. J.Biol.Chem. V. 278 12406 2003.
ISSN: ISSN 0021-9258
PubMed: 12547827
DOI: 10.1074/JBC.M212491200
Page generated: Sun Dec 13 11:32:02 2020
ISSN: ISSN 0021-9258
PubMed: 12547827
DOI: 10.1074/JBC.M212491200
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