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Atomistry » Fluorine » PDB 1q6n-1rrx » 1r35 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 1q6n-1rrx » 1r35 » |
Fluorine in PDB 1r35: Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-LysineEnzymatic activity of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine
All present enzymatic activity of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine:
1.14.13.39; Protein crystallography data
The structure of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine, PDB code: 1r35
was solved by
H.S.Shieh,
A.M.Stevens,
W.C.Stallings,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 1r35:
The structure of Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine
(pdb code 1r35). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine, PDB code: 1r35: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 1r35Go back to Fluorine Binding Sites List in 1r35
Fluorine binding site 1 out
of 2 in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 1r35Go back to Fluorine Binding Sites List in 1r35
Fluorine binding site 2 out
of 2 in the Murine Inducible Nitric Oxide Synthase Oxygenase Dimer, Tetrahydrobiopterin and 4R-Fluoro-N6-Ethanimidoyl-L-Lysine
Mono view Stereo pair view
Reference:
E.A.Hallinan,
S.W.Kramer,
S.C.Houdek,
W.M.Moore,
G.M.Jerome,
D.P.Spangler,
A.M.Stevens,
H.S.Shieh,
P.T.Manning,
B.S.Pitzele.
4-Fluorinated L-Lysine Analogs As Selective I-Nos Inhibitors: Methodology For Introducing Fluorine Into the Lysine Side Chain. Org.Biomol.Chem. V. 1 3527 2003.
Page generated: Wed Jul 31 12:35:09 2024
ISSN: ISSN 1477-0520 PubMed: 14599013 DOI: 10.1039/B307563J |
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