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Fluorine in PDB 1tgv: Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate

Enzymatic activity of Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate

All present enzymatic activity of Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate:
2.4.2.3;

Protein crystallography data

The structure of Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate, PDB code: 1tgv was solved by W.Bu, E.C.Settembre, J.M.Sanders, T.P.Begley, S.E.Ealick, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.20
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 149.972, 149.972, 49.566, 90.00, 90.00, 120.00
R / Rfree (%) 17.5 / 22.4

Other elements in 1tgv:

The structure of Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate also contains other interesting chemical elements:

Potassium (K) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate (pdb code 1tgv). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate, PDB code: 1tgv:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 1tgv

Go back to Fluorine Binding Sites List in 1tgv
Fluorine binding site 1 out of 2 in the Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F3001

b:35.9
occ:1.00
F5 A:5UD3001 0.0 35.9 1.0
C5 A:5UD3001 1.3 33.2 1.0
C4 A:5UD3001 2.4 31.5 1.0
C6 A:5UD3001 2.4 32.0 1.0
O4 A:5UD3001 2.7 27.8 1.0
CG1 A:ILE220 3.2 26.0 1.0
CD1 A:ILE220 3.2 23.6 1.0
CG1 A:VAL221 3.3 31.9 1.0
C A:THR95 3.4 25.7 1.0
O A:THR95 3.5 23.3 1.0
N A:GLY96 3.6 24.3 1.0
N3 A:5UD3001 3.7 28.8 1.0
N1 A:5UD3001 3.7 32.2 1.0
CA A:GLY96 3.8 23.6 1.0
CA A:THR95 4.1 25.0 1.0
C2 A:5UD3001 4.2 30.6 1.0
N A:THR95 4.3 25.8 1.0
CB A:VAL221 4.5 30.8 1.0
CB A:ILE220 4.7 27.8 1.0
O A:HOH3035 4.7 40.5 1.0
N A:VAL221 4.8 28.7 1.0
CE1 A:PHE162 4.9 23.6 1.0
NH2 A:ARG168 4.9 32.5 1.0
C1' A:5UD3001 4.9 36.4 1.0
C A:THR94 4.9 24.8 1.0

Fluorine binding site 2 out of 2 in 1tgv

Go back to Fluorine Binding Sites List in 1tgv
Fluorine binding site 2 out of 2 in the Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of E. Coli Uridine Phosphorylase Complexed with 5- Fluorouridine and Sulfate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F5002

b:36.5
occ:1.00
F5 B:5UD5002 0.0 36.5 1.0
C5 B:5UD5002 1.3 34.5 1.0
C4 B:5UD5002 2.4 33.7 1.0
C6 B:5UD5002 2.4 33.6 1.0
O4 B:5UD5002 2.7 32.9 1.0
C B:THR95 3.2 25.6 1.0
CG1 B:ILE220 3.3 26.0 1.0
CD1 B:ILE220 3.3 24.7 1.0
N B:GLY96 3.3 26.0 1.0
O B:THR95 3.4 23.8 1.0
CG1 B:VAL221 3.6 32.2 1.0
N3 B:5UD5002 3.7 32.9 1.0
N1 B:5UD5002 3.7 32.9 1.0
CA B:THR95 3.7 24.9 1.0
CA B:GLY96 3.8 26.0 1.0
N B:THR95 4.0 25.5 1.0
C2 B:5UD5002 4.2 31.5 1.0
C B:THR94 4.6 25.6 1.0
O B:HOH5084 4.7 33.9 1.0
CB B:VAL221 4.8 31.1 1.0
CB B:ILE220 4.8 25.8 1.0
C1' B:5UD5002 4.9 34.4 1.0
O B:THR94 4.9 25.2 1.0
CE1 B:PHE162 4.9 24.7 1.0
N B:VAL221 5.0 28.1 1.0

Reference:

W.Bu, E.C.Settembre, J.M.Sanders, T.P.Begley, S.E.Ealick. Structures of E. Coli Uridine Phosphorylase To Be Published 2004.
Page generated: Wed Jul 31 12:57:11 2024

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