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Fluorine in PDB 1xh5: Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
Enzymatic activity of Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
All present enzymatic activity of Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants:
2.7.1.37;
2.7.1.37;
Protein crystallography data
The structure of Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants, PDB code: 1xh5
was solved by
C.B.Breitenlechner,
W.-G.Friebe,
E.Brunet,
G.Werner,
K.Graul,
U.Thomas,
K.-P.Kuenkele,
W.Schaefer,
M.Gassel,
D.Bossemeyer,
R.Huber,
R.A.Engh,
B.Masjost,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 18.63 / 2.05 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.094, 76.806, 79.532, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.2 / 23.6 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
(pdb code 1xh5). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants, PDB code: 1xh5:
In total only one binding site of Fluorine was determined in the Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants, PDB code: 1xh5:
Fluorine binding site 1 out of 1 in 1xh5
Go back to
Fluorine Binding Sites List in 1xh5
Fluorine binding site 1 out
of 1 in the Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants within 5.0Å range:
|
Reference:
C.B.Breitenlechner,
W.-G.Friebe,
E.Brunet,
G.Werner,
K.Graul,
U.Thomas,
K.-P.Kuenkele,
W.Schaefer,
M.Gassel,
D.Bossemeyer,
R.Huber,
R.A.Engh,
B.Masjost.
Design and Crystal Structures of Protein Kinase B-Selective Inhibitors in Complex with Protein Kinase A and Mutants J.Med.Chem. V. 48 163 2005.
ISSN: ISSN 0022-2623
PubMed: 15634010
DOI: 10.1021/JM049701N
Page generated: Wed Jul 31 13:17:58 2024
ISSN: ISSN 0022-2623
PubMed: 15634010
DOI: 10.1021/JM049701N
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