Fluorine in PDB 1ze2: Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate

All present enzymatic activity of Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate:
4.2.1.70;

The structure of Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate, PDB code: 1ze2 was solved by K.Phannachet, R.H.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 3.00
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	134.975, 134.975, 139.537, 90.00, 90.00, 90.00
R / Rfree (%)	26.1 / 31.8

The binding sites of Fluorine atom in the Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate (pdb code 1ze2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate, PDB code: 1ze2:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate within 5.0Å range: probe atom residue distance (Å) B Occ C:F10 b:36.5 occ:1.00 F5 C:FHU10 0.0 36.5 1.0 C5 C:FHU10 1.3 33.3 1.0 C1' C:FHU10 2.3 35.1 1.0 C4 C:FHU10 2.3 30.3 1.0 C6 C:FHU10 2.3 33.6 1.0 C2' C:FHU10 2.7 34.8 1.0 O6 C:FHU10 2.7 35.9 1.0 O4 C:FHU10 2.8 28.8 1.0 O4' C:FHU10 2.8 36.6 1.0 C5' C:FHU10 3.2 37.0 1.0 OH A:TYR67 3.2 25.9 1.0 C4' C:FHU10 3.4 34.7 1.0 O A:THR37 3.5 27.9 1.0 N3 C:FHU10 3.6 30.8 1.0 N1 C:FHU10 3.6 32.2 1.0 C3' C:FHU10 3.7 32.1 1.0 O2' C:FHU10 3.8 35.0 1.0 C2 C:FHU10 4.1 32.5 1.0 CZ A:TYR67 4.1 28.0 1.0 NH1 A:ARG193 4.2 23.6 1.0 CE2 A:TYR67 4.3 27.5 1.0 O5' C:FHU10 4.5 39.0 1.0 CD2 A:LEU38 4.5 20.9 1.0 C A:THR37 4.6 26.0 1.0 OP1 C:FHU10 4.7 37.0 1.0 CA A:LEU38 4.8 20.2 1.0 CZ A:ARG193 4.8 22.9 1.0 O3' C:FHU10 4.9 29.0 1.0 O A:THR169 5.0 24.8 1.0

Fluorine binding site 2 out of 2 in the Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate within 5.0Å range: probe atom residue distance (Å) B Occ D:F10 b:85.1 occ:1.00 F5 D:FHU10 0.0 85.1 1.0 C5 D:FHU10 1.3 83.8 1.0 C4 D:FHU10 2.3 84.0 1.0 C1' D:FHU10 2.3 82.5 1.0 C6 D:FHU10 2.3 84.7 1.0 C2' D:FHU10 2.6 82.1 1.0 O6 D:FHU10 2.7 84.8 1.0 O4 D:FHU10 2.8 84.1 1.0 O4' D:FHU10 3.0 82.3 1.0 OH B:TYR67 3.3 97.3 1.0 O2' D:FHU10 3.5 83.5 1.0 N3 D:FHU10 3.6 85.2 1.0 N1 D:FHU10 3.6 85.1 1.0 C5' D:FHU10 3.7 77.8 1.0 C4' D:FHU10 3.7 80.6 1.0 O B:THR37 3.8 71.6 1.0 C3' D:FHU10 3.8 81.9 1.0 NH2 B:ARG193 3.9 80.1 1.0 C2 D:FHU10 4.1 85.5 1.0 CZ B:TYR67 4.2 99.5 1.0 CZ B:ARG193 4.2 80.5 1.0 CG B:LEU38 4.3 71.7 1.0 CA B:LEU38 4.3 72.2 1.0 CE2 B:TYR67 4.3 99.9 1.0 CD2 B:LEU38 4.3 71.3 1.0 NH1 B:ARG193 4.3 80.0 1.0 N B:ASP39 4.6 76.1 1.0 CB B:LEU38 4.8 71.5 1.0 C B:THR37 4.8 69.0 1.0 O3' D:FHU10 4.9 81.8 1.0 O5' D:FHU10 5.0 73.5 1.0

K.Phannachet, R.H.Huang. Conformational Change of Pseudouridine 55 Synthase Upon Its Association with Rna Substrate Nucleic Acids Res. V. 32 1422 2004.
ISSN: ISSN 0305-1048
PubMed: 14990747
DOI: 10.1093/NAR/GKH287