Fluorine in PDB 2ab4: Dissecting the Roles of A Strictly Conserved Tyrosine in Substrate Recognition and Catalysis By Pseudouridine 55 Synthase

The structure of Dissecting the Roles of A Strictly Conserved Tyrosine in Substrate Recognition and Catalysis By Pseudouridine 55 Synthase, PDB code: 2ab4 was solved by K.Phannachet, Y.Elias, R.H.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.40
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	157.870, 51.870, 57.150, 90.00, 90.00, 90.00
R / Rfree (%)	22.2 / 27.2

The structure of Dissecting the Roles of A Strictly Conserved Tyrosine in Substrate Recognition and Catalysis By Pseudouridine 55 Synthase also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Fluorine atom in the Dissecting the Roles of A Strictly Conserved Tyrosine in Substrate Recognition and Catalysis By Pseudouridine 55 Synthase (pdb code 2ab4). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Dissecting the Roles of A Strictly Conserved Tyrosine in Substrate Recognition and Catalysis By Pseudouridine 55 Synthase, PDB code: 2ab4:

Fluorine binding site 1 out of 1 in the Dissecting the Roles of A Strictly Conserved Tyrosine in Substrate Recognition and Catalysis By Pseudouridine 55 Synthase


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Dissecting the Roles of A Strictly Conserved Tyrosine in Substrate Recognition and Catalysis By Pseudouridine 55 Synthase within 5.0Å range: probe atom residue distance (Å) B Occ B:F10 b:30.1 occ:1.00 F5 B:FHU10 0.0 30.1 1.0 C5 B:FHU10 1.3 31.7 1.0 C1' B:FHU10 2.3 32.7 1.0 C4 B:FHU10 2.3 29.9 1.0 C6 B:FHU10 2.4 29.1 1.0 C2' B:FHU10 2.7 35.8 1.0 O6 B:FHU10 2.8 33.5 1.0 O4 B:FHU10 2.8 29.3 1.0 O A:HOH316 2.8 16.8 1.0 O4' B:FHU10 2.8 34.7 1.0 C5' B:FHU10 3.3 34.6 1.0 C4' B:FHU10 3.5 34.8 1.0 NH1 A:ARG193 3.6 21.7 1.0 N3 B:FHU10 3.6 31.0 1.0 N1 B:FHU10 3.6 31.0 1.0 O A:THR37 3.7 25.6 1.0 CZ A:PHE67 3.8 17.3 1.0 O2' B:FHU10 3.8 37.3 1.0 C3' B:FHU10 3.8 34.0 1.0 CE2 A:PHE67 3.9 17.1 1.0 C2 B:FHU10 4.1 30.3 1.0 CD2 A:LEU38 4.4 28.6 1.0 CZ A:ARG193 4.6 21.5 1.0 CA A:LEU38 4.6 26.4 1.0 O5' B:FHU10 4.6 34.1 1.0 CD A:ARG193 4.8 19.0 1.0 C A:THR37 4.8 24.1 1.0 O3' B:FHU10 4.9 33.7 1.0 CG A:LEU38 4.9 29.3 1.0 CE1 A:PHE67 5.0 15.8 1.0

K.Phannachet, Y.Elias, R.H.Huang. Dissecting the Roles of A Strictly Conserved Tyrosine in Substrate Recognition and Catalysis By Pseudouridine 55 Synthase. Biochemistry V. 44 15488 2005.
ISSN: ISSN 0006-2960
PubMed: 16300397
DOI: 10.1021/BI050961W