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Fluorine in PDB 2am4: Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose

Enzymatic activity of Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose

All present enzymatic activity of Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose:
2.4.1.101;

Protein crystallography data

The structure of Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose, PDB code: 2am4 was solved by J.M.Rini, R.D.Gordon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.80 / 1.70
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 40.917, 82.501, 102.394, 90.00, 90.00, 90.00
R / Rfree (%) 19.3 / 21.7

Other elements in 2am4:

The structure of Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose also contains other interesting chemical elements:

Manganese (Mn) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose (pdb code 2am4). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose, PDB code: 2am4:

Fluorine binding site 1 out of 1 in 2am4

Go back to Fluorine Binding Sites List in 2am4
Fluorine binding site 1 out of 1 in the Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of N-Acetylglucosaminyltransferase I in Complex with Udp-2-Deoxy-2-Fluoro-Glucose within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F449

b:20.2
occ:1.00
 F1 A:U2F449 0.0 20.2 1.0
C2 A:U2F449 1.4 17.7 1.0
C1 A:U2F449 2.3 17.2 1.0
C3 A:U2F449 2.4 20.3 1.0
CE2 A:TYR184 2.9 24.4 1.0
O3 A:U2F449 3.0 22.7 1.0
O1 A:U2F449 3.1 18.1 1.0
CD2 A:TYR184 3.3 17.9 1.0
O5 A:U2F449 3.6 19.8 1.0
CZ A:TYR184 3.6 21.5 1.0
CD1 A:ILE187 3.8 10.8 1.0
C4 A:U2F449 3.8 15.3 1.0
CG1 A:VAL321 3.8 16.9 1.0
O A:HOH526 4.0 20.2 1.0
OH A:TYR184 4.1 27.6 1.0
PB A:U2F449 4.1 14.1 1.0
CB A:VAL321 4.2 14.2 1.0
CB A:SER322 4.2 25.4 1.0
C5 A:U2F449 4.2 20.5 1.0
CG A:TYR184 4.2 12.5 1.0
O3A A:U2F449 4.3 11.4 1.0
N A:SER322 4.4 18.5 1.0
CE1 A:TYR184 4.5 15.7 1.0
O1B A:U2F449 4.7 18.2 1.0
CD1 A:TYR184 4.7 13.2 1.0
OG A:SER322 4.8 26.2 1.0
CA A:SER322 4.8 22.1 1.0
O4 A:U2F449 4.9 18.2 1.0
C A:VAL321 4.9 18.6 1.0

Reference:

R.D.Gordon, P.Sivarajah, M.Satkunarajah, D.Ma, C.A.Tarling, D.Vizitiu, S.G.Withers, J.M.Rini. X-Ray Crystal Structures of Rabbit N-Acetylglucosaminyltransferase I (Gnt I) in Complex with Donor Substrate Analogues. J.Mol.Biol. V. 360 67 2006.
ISSN: ISSN 0022-2836
PubMed: 16769084
DOI: 10.1016/J.JMB.2006.04.058
Page generated: Wed Jul 31 13:45:02 2024

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