Fluorine in PDB 2bml: Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall Degrading Virulence Factors

All present enzymatic activity of Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall Degrading Virulence Factors:
3.5.1.28;

The structure of Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall Degrading Virulence Factors, PDB code: 2bml was solved by C.Fernandez-Tornero, G.Gimenez-Gallego, A.Romero, E.Garcia, B.D.Pascual-Teresa, R.Lopez, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	6.00 / 2.6
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	101.670, 94.480, 38.100, 90.00, 90.00, 90.00
R / Rfree (%)	22 / 28

The binding sites of Fluorine atom in the Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall Degrading Virulence Factors (pdb code 2bml). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall Degrading Virulence Factors, PDB code: 2bml:

Fluorine binding site 1 out of 1 in the Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall Degrading Virulence Factors


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall Degrading Virulence Factors within 5.0Å range: probe atom residue distance (Å) B Occ B:F1319 b:83.8 occ:1.00 F11 B:XED1319 0.0 83.8 1.0 C10 B:XED1319 1.3 82.2 1.0 C13 B:XED1319 2.4 83.2 1.0 C8 B:XED1319 2.4 80.3 1.0 O B:HOH2009 2.7 39.0 1.0 N3 B:XED1319 2.8 77.3 1.0 C1 B:XED1319 3.3 75.8 1.0 CD1 B:TRP220 3.4 37.9 1.0 NE1 B:TRP220 3.5 37.3 1.0 C14 B:XED1319 3.7 84.2 1.0 C9 B:XED1319 3.7 82.0 1.0 C2 B:XED1319 4.1 74.5 1.0 C5 B:XED1319 4.2 76.6 1.0 C12 B:XED1319 4.2 83.7 1.0 CG B:TRP220 4.5 37.8 1.0 CE2 B:TRP220 4.7 38.4 1.0 C6 B:XED1319 4.9 75.5 1.0 O15 B:XED1319 4.9 82.3 1.0 C22 B:XED1319 5.0 85.6 1.0

C.Fernandez-Tornero, E.Garcia, R.Lopez, B.D.Pascual-Teresa, G.Gimenez-Gallego, A.Romero. Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall-Degrading Virulence Factors J.Biol.Chem. V. 280 19948 2005.
ISSN: ISSN 0021-9258
PubMed: 15769740
DOI: 10.1074/JBC.M501236200