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Fluorine in PDB 2buc: Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor
Enzymatic activity of Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor
All present enzymatic activity of Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor:
3.4.14.5;
3.4.14.5;
Protein crystallography data
The structure of Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor, PDB code: 2buc
was solved by
S.Nordhoff,
S.Cerezo-Galvez,
A.Feurer,
O.Hill,
V.G.Matassa,
G.Metz,
C.Rummey,
M.Thiemann,
P.J.Edwards,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 19.28 / 2.50 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 61.644, 117.491, 133.057, 112.44, 94.72, 91.30 |
| R / Rfree (%) | 22.1 / 27.9 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor
(pdb code 2buc). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor, PDB code: 2buc:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor, PDB code: 2buc:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 2buc
Go back to
Fluorine Binding Sites List in 2buc
Fluorine binding site 1 out
of 4 in the Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 2buc
Go back to
Fluorine Binding Sites List in 2buc
Fluorine binding site 2 out
of 4 in the Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 2buc
Go back to
Fluorine Binding Sites List in 2buc
Fluorine binding site 3 out
of 4 in the Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 2buc
Go back to
Fluorine Binding Sites List in 2buc
Fluorine binding site 4 out
of 4 in the Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with A Tetrahydroisoquinoline Inhibitor within 5.0Å range:
|
Reference:
S.Nordhoff,
S.Cerezo-Galvez,
A.Feurer,
O.Hill,
V.G.Matassa,
G.Metz,
C.Rummey,
M.Thiemann,
P.J.Edwards.
The Reversed Binding of Beta-Phenethylamine Inhibitors of Dpp-IV: X-Ray Structures and Properties of Novel Fragment and Elaborated Inhibitors. Bioorg. Med. Chem. Lett. V. 16 1744 2006.
ISSN: ISSN 0960-894X
PubMed: 16376544
DOI: 10.1016/J.BMCL.2005.11.103
Page generated: Wed Jul 31 13:53:20 2024
ISSN: ISSN 0960-894X
PubMed: 16376544
DOI: 10.1016/J.BMCL.2005.11.103
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