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Fluorine in PDB 2ea2: H-METAP2 Complexed with A773812

Enzymatic activity of H-METAP2 Complexed with A773812

All present enzymatic activity of H-METAP2 Complexed with A773812:
3.4.11.18;

Protein crystallography data

The structure of H-METAP2 Complexed with A773812, PDB code: 2ea2 was solved by C.H.Park, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 16.91 / 2.50
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 89.721, 99.060, 100.855, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 2ea2:

The structure of H-METAP2 Complexed with A773812 also contains other interesting chemical elements:

Manganese (Mn) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the H-METAP2 Complexed with A773812 (pdb code 2ea2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the H-METAP2 Complexed with A773812, PDB code: 2ea2:

Fluorine binding site 1 out of 1 in 2ea2

Go back to Fluorine Binding Sites List in 2ea2
Fluorine binding site 1 out of 1 in the H-METAP2 Complexed with A773812


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of H-METAP2 Complexed with A773812 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F482

b:27.5
occ:1.00
F23 A:F77482 0.0 27.5 1.0
C20 A:F77482 1.3 27.2 1.0
C21 A:F77482 2.3 27.3 1.0
C19 A:F77482 2.4 27.1 1.0
CB A:ALA230 3.0 15.4 1.0
CD2 A:LEU328 3.3 19.5 1.0
CZ A:PHE366 3.4 16.4 1.0
C22 A:F77482 3.6 27.2 1.0
C18 A:F77482 3.6 27.1 1.0
CD1 A:LEU328 3.8 19.9 1.0
CE1 A:PHE366 3.9 16.4 1.0
CE2 A:PHE366 4.0 16.6 1.0
CD1 A:LEU447 4.0 17.0 1.0
CG A:LEU328 4.1 20.0 1.0
C17 A:F77482 4.1 27.1 1.0
CA A:ALA230 4.5 15.6 1.0
NE2 A:HIS231 4.6 15.9 1.0
O12 A:F77482 4.7 25.7 1.0
CB A:LEU328 4.7 20.1 1.0
CD2 A:HIS231 4.8 16.0 1.0
CE1 A:HIS231 4.9 16.2 1.0
CD1 A:PHE366 4.9 16.8 1.0
N A:ALA230 4.9 15.3 1.0
CD2 A:PHE366 5.0 16.8 1.0

Reference:

G.T.Wang, R.A.Mantei, M.Kawai, J.S.Tedrow, D.M.Barnes, J.Wang, Q.Zhang, P.Lou, L.A.Garcia, J.Bouska, M.Yates, C.Park, R.A.Judge, R.Lesniewski, G.S.Sheppard, R.L.Bell. Lead Optimization of Methionine Aminopeptidase-2 (METAP2) Inhibitors Containing Sulfonamides of 5,6-Disubstituted Anthranilic Acids Bioorg.Med.Chem.Lett. V. 17 2817 2007.
ISSN: ISSN 0960-894X
PubMed: 17350258
DOI: 10.1016/J.BMCL.2007.02.062
Page generated: Sun Dec 13 11:35:43 2020

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