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Fluorine in PDB 2hm1: Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2)

Enzymatic activity of Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2)

All present enzymatic activity of Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2):
3.4.23.46;

Protein crystallography data

The structure of Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2), PDB code: 2hm1 was solved by T.E.Benson, D.B.Prince, A.G.Tomasselli, T.L.Emmons, D.J.Paddock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.20
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 72.990, 104.880, 50.060, 90.00, 94.99, 90.00
R / Rfree (%) 20.4 / 25.1

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2) (pdb code 2hm1). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2), PDB code: 2hm1:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in 2hm1

Go back to Fluorine Binding Sites List in 2hm1
Fluorine binding site 1 out of 2 in the Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F801

b:29.0
occ:1.00
F19 A:LIQ801 0.0 29.0 1.0
C19 A:LIQ801 1.3 26.4 1.0
C20 A:LIQ801 2.4 25.1 1.0
C18 A:LIQ801 2.4 26.4 1.0
O A:GLN73 3.1 42.0 1.0
CD1 A:PHE108 3.3 29.4 1.0
CA A:PHE108 3.7 29.9 1.0
CA A:GLY74 3.8 36.6 1.0
O A:LYS107 3.8 31.8 1.0
C17 A:LIQ801 3.8 26.1 1.0
C15 A:LIQ801 3.8 25.1 1.0
C A:GLY74 4.0 34.6 1.0
CE1 A:PHE108 4.0 27.6 1.0
CD2 A:TYR71 4.0 24.4 1.0
C A:GLN73 4.1 41.3 1.0
O A:HOH1066 4.1 37.1 1.0
O A:HOH940 4.2 27.8 1.0
CG A:PHE108 4.2 29.3 1.0
O A:PHE108 4.2 29.4 1.0
CB A:PHE108 4.2 29.4 1.0
O A:GLY74 4.2 33.6 1.0
CG A:TYR71 4.3 26.3 1.0
CB A:TYR71 4.3 28.4 1.0
C16 A:LIQ801 4.3 25.1 1.0
C A:PHE108 4.5 29.0 1.0
N A:GLY74 4.5 39.2 1.0
C A:LYS107 4.6 31.9 1.0
N A:PHE108 4.6 30.2 1.0
N A:LYS75 4.6 32.8 1.0
O A:HOH948 4.7 35.5 1.0
O3 A:LIQ801 4.7 25.7 1.0
CE2 A:TYR71 4.7 24.4 1.0
F17 A:LIQ801 4.9 29.3 1.0

Fluorine binding site 2 out of 2 in 2hm1

Go back to Fluorine Binding Sites List in 2hm1
Fluorine binding site 2 out of 2 in the Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of Human Beta-Secretase (Bace) in the Presence of An Inhibitor (2) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F801

b:29.3
occ:1.00
F17 A:LIQ801 0.0 29.3 1.0
C17 A:LIQ801 1.3 26.1 1.0
C16 A:LIQ801 2.4 25.1 1.0
C18 A:LIQ801 2.4 26.4 1.0
CZ2 A:TRP115 3.0 20.4 1.0
CH2 A:TRP115 3.3 22.6 1.0
C3 A:LIQ801 3.3 32.7 1.0
CD1 A:ILE110 3.4 31.4 1.0
C1 A:LIQ801 3.5 34.2 1.0
C15 A:LIQ801 3.7 25.1 1.0
C19 A:LIQ801 3.8 26.4 1.0
O A:HOH948 3.9 35.5 1.0
C2 A:LIQ801 4.0 33.1 1.0
CD2 A:LEU30 4.0 18.1 1.0
O A:PHE108 4.1 29.4 1.0
CG1 A:ILE110 4.1 31.2 1.0
C1A A:LIQ801 4.2 36.8 1.0
CE2 A:TRP115 4.3 21.2 1.0
C20 A:LIQ801 4.3 25.1 1.0
O A:HOH940 4.5 27.8 1.0
CZ3 A:TRP115 4.7 21.9 1.0
C7 A:LIQ801 4.7 30.4 1.0
C9 A:LIQ801 4.7 27.8 1.0
F19 A:LIQ801 4.9 29.0 1.0
NE1 A:TRP115 4.9 21.7 1.0

Reference:

J.N.Freskos, Y.M.Fobian, T.E.Benson, J.B.Moon, M.J.Bienkowski, D.L.Brown, T.L.Emmons, R.Heintz, A.Laborde, J.J.Mcdonald, B.V.Mischke, J.M.Molyneaux, P.B.Mullins, D.Bryan Prince, D.J.Paddock, A.G.Tomasselli, G.Winterrowd. Design of Potent Inhibitors of Human Beta-Secretase. Part 2. Bioorg.Med.Chem.Lett. V. 17 78 2007.
ISSN: ISSN 0960-894X
PubMed: 17049233
DOI: 10.1016/J.BMCL.2006.09.091
Page generated: Sun Dec 13 11:36:51 2020

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