Fluorine in PDB 2i82: Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure

All present enzymatic activity of Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure:
4.2.1.70;

The structure of Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure, PDB code: 2i82 was solved by C.Hoang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.83 / 2.05
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	320.737, 51.691, 81.233, 90.00, 90.81, 90.00
R / Rfree (%)	23.4 / 26.3

The binding sites of Fluorine atom in the Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure (pdb code 2i82). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure, PDB code: 2i82:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure within 5.0Å range: probe atom residue distance (Å) B Occ E:F3001 b:58.6 occ:1.00 F1 E:FOU3001 0.0 58.6 1.0 C4 E:FOU3001 1.4 57.3 1.0 C3 E:FOU3001 2.4 55.2 1.0 C1 E:FOU3001 2.4 58.1 1.0 C1' E:N1208 2.5 25.8 1.0 O1 E:FOU3001 2.6 59.2 1.0 O3 E:FOU3001 2.7 56.7 1.0 OH A:TYR96 2.8 34.7 1.0 C2' E:N1208 2.9 25.8 1.0 O4' E:N1208 2.9 27.6 1.0 C5' E:N1208 3.3 26.5 1.0 C4' E:N1208 3.5 25.3 1.0 N2 E:FOU3001 3.7 54.0 1.0 O A:ARG62 3.7 24.3 1.0 C3' E:N1208 3.7 22.5 1.0 N1 E:FOU3001 3.7 56.9 1.0 CZ A:TYR96 3.7 30.7 1.0 O5' E:N1208 3.9 22.4 1.0 CD1 A:LEU63 4.0 29.3 1.0 O2' E:N1208 4.1 24.4 1.0 O A:HOH2043 4.2 34.0 1.0 C2 E:FOU3001 4.2 54.2 1.0 CA A:LEU63 4.3 26.5 1.0 CE2 A:TYR96 4.3 29.1 1.0 O A:HOH2049 4.4 37.8 1.0 CG A:LEU63 4.5 33.8 1.0 CE1 A:TYR96 4.7 31.3 1.0 N A:ASP64 4.7 24.6 1.0 C A:ARG62 4.7 26.4 1.0 OP1 E:N1208 4.9 18.9 1.0 CB A:LEU63 5.0 26.5 1.0

Fluorine binding site 2 out of 2 in the Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure within 5.0Å range: probe atom residue distance (Å) B Occ G:F3003 b:69.0 occ:1.00 F1 G:FOU3003 0.0 69.0 1.0 C4 G:FOU3003 1.4 66.3 1.0 C3 G:FOU3003 2.4 66.5 1.0 O1 G:FOU3003 2.4 63.4 1.0 C1 G:FOU3003 2.4 66.3 1.0 C1' G:N1408 2.6 38.7 1.0 O3 G:FOU3003 2.6 69.8 1.0 O4' G:N1408 2.7 41.4 1.0 N1 G:FOU3003 3.5 66.6 1.0 N2 G:FOU3003 3.7 65.8 1.0 N C:LEU764 3.7 38.7 1.0 CG C:LEU764 3.7 37.5 1.0 CB C:GLN763 3.7 43.1 1.0 N C:GLN763 3.9 38.9 1.0 O C:ARG760 4.1 47.3 1.0 C2' G:N1408 4.1 41.3 1.0 C4' G:N1408 4.1 40.8 1.0 C2 G:FOU3003 4.1 65.6 1.0 CA C:GLN763 4.2 37.9 1.0 CB C:LEU764 4.2 36.8 1.0 CD1 C:LEU764 4.2 34.9 1.0 C C:GLN763 4.5 38.1 1.0 CB C:PRO756 4.6 43.8 1.0 CA C:LEU764 4.6 37.4 1.0 O2' G:N1408 4.6 36.2 1.0 C C:HIS762 4.7 38.0 1.0 C5' G:N1408 4.8 36.9 1.0 C3' G:N1408 4.8 39.7 1.0 CG C:GLN763 4.8 45.2 1.0 O5' G:N1408 4.8 39.2 1.0 CD2 C:LEU764 4.8 35.9 1.0 N C:HIS762 5.0 40.8 1.0

C.Hoang, J.Chen, C.A.Vizthum, J.M.Kandel, C.S.Hamilton, E.G.Mueller, A.R.Ferre-D'amare. Crystal Structure of Pseudouridine Synthase Rlua: Indirect Sequence Readout Through Protein-Induced Rna Structure Mol.Cell V. 24 535 2006.
ISSN: ISSN 1097-2765
PubMed: 17188032
DOI: 10.1016/J.MOLCEL.2006.09.017