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Fluorine in PDB 2ilt: Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor
Enzymatic activity of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor
All present enzymatic activity of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor:
1.1.1.146;
1.1.1.146;
Protein crystallography data
The structure of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor, PDB code: 2ilt
was solved by
K.L.Longenecker,
B.Sorensen,
R.Judge,
W.Qin,
J.T.Link,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 87.71 / 2.30 |
| Space group | I 2 3 |
| Cell size a, b, c (Å), α, β, γ (°) | 123.871, 123.871, 123.871, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.9 / 27.5 |
Other elements in 2ilt:
The structure of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor also contains other interesting chemical elements:
| Nickel | (Ni) | 2 atoms |
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor
(pdb code 2ilt). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor, PDB code: 2ilt:
In total only one binding site of Fluorine was determined in the Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor, PDB code: 2ilt:
Fluorine binding site 1 out of 1 in 2ilt
Go back to
Fluorine Binding Sites List in 2ilt
Fluorine binding site 1 out
of 1 in the Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human 11-Beta-Hydroxysteroid Dehydrogenase (HSD1) with Nadp and Adamantane Sulfone Inhibitor within 5.0Å range:
|
Reference:
B.Sorensen,
M.Winn,
J.Rohde,
Q.Shuai,
J.Wang,
S.Fung,
K.Monzon,
W.Chiou,
D.Stolarik,
H.Imade,
L.Pan,
X.Deng,
L.Chovan,
K.Longenecker,
R.Judge,
W.Qin,
M.Brune,
H.Camp,
E.U.Frevert,
P.Jacobson,
J.T.Link.
Adamantane Sulfone and Sulfonamide 11-Beta-HSD1 Inhibitors. Bioorg.Med.Chem.Lett. V. 17 527 2007.
ISSN: ISSN 0960-894X
PubMed: 17070044
DOI: 10.1016/J.BMCL.2006.10.008
Page generated: Wed Jul 31 14:54:33 2024
ISSN: ISSN 0960-894X
PubMed: 17070044
DOI: 10.1016/J.BMCL.2006.10.008
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