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Fluorine in PDB 2np8: Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
Enzymatic activity of Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
All present enzymatic activity of Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors:
2.7.11.1;
2.7.11.1;
Protein crystallography data
The structure of Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors, PDB code: 2np8
was solved by
L.W.Tari,
I.D.Hoffman,
D.C.Bensen,
M.J.Hunter,
J.Nix,
K.J.Nelson,
D.E.Mcree,
R.V.Swanson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 70.53 / 2.25 |
| Space group | P 61 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 81.544, 81.544, 172.038, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 24.4 / 28.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
(pdb code 2np8). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors, PDB code: 2np8:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors, PDB code: 2np8:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 2np8
Go back to
Fluorine Binding Sites List in 2np8
Fluorine binding site 1 out
of 3 in the Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 2np8
Go back to
Fluorine Binding Sites List in 2np8
Fluorine binding site 2 out
of 3 in the Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 2np8
Go back to
Fluorine Binding Sites List in 2np8
Fluorine binding site 3 out
of 3 in the Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors within 5.0Å range:
|
Reference:
L.W.Tari,
I.D.Hoffman,
D.C.Bensen,
M.J.Hunter,
J.Nix,
K.J.Nelson,
D.E.Mcree,
R.V.Swanson.
Structural Basis For the Inhibition of Aurora A Kinase By A Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors. Bioorg.Med.Chem.Lett. V. 17 688 2007.
ISSN: ISSN 0960-894X
PubMed: 17157005
DOI: 10.1016/J.BMCL.2006.10.086
Page generated: Sun Dec 13 11:38:13 2020
ISSN: ISSN 0960-894X
PubMed: 17157005
DOI: 10.1016/J.BMCL.2006.10.086
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