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Fluorine in PDB 2oo8: Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors
Enzymatic activity of Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors
All present enzymatic activity of Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors, PDB code: 2oo8
was solved by
S.F.Bellon,
J.Kim,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 59.13 / 2.20 |
| Space group | P 41 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 62.604, 62.604, 181.043, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 23.3 / 27.9 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors
(pdb code 2oo8). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors, PDB code: 2oo8:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors, PDB code: 2oo8:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 2oo8
Go back to
Fluorine Binding Sites List in 2oo8
Fluorine binding site 1 out
of 3 in the Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 2oo8
Go back to
Fluorine Binding Sites List in 2oo8
Fluorine binding site 2 out
of 3 in the Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 2oo8
Go back to
Fluorine Binding Sites List in 2oo8
Fluorine binding site 3 out
of 3 in the Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors within 5.0Å range:
|
Reference:
B.L.Hodous,
S.D.Geuns-Meyer,
P.E.Hughes,
B.K.Albrecht,
S.Bellon,
S.Caenepeel,
V.J.Cee,
S.C.Chaffee,
M.Emery,
J.Fretland,
P.Gallant,
Y.Gu,
R.E.Johnson,
J.L.Kim,
A.M.Long,
M.Morrison,
P.R.Olivieri,
V.F.Patel,
A.Polverino,
P.Rose,
L.Wang,
H.Zhao.
Synthesis, Structural Analysis, and Sar Studies of Triazine Derivatives As Potent, Selective Tie-2 Inhibitors. Bioorg.Med.Chem.Lett. V. 17 2886 2007.
ISSN: ISSN 0960-894X
PubMed: 17350837
DOI: 10.1016/J.BMCL.2007.02.067
Page generated: Wed Jul 31 15:23:54 2024
ISSN: ISSN 0960-894X
PubMed: 17350837
DOI: 10.1016/J.BMCL.2007.02.067
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