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Atomistry » Fluorine » PDB 2oh4-2pdk » 2opm » |
Fluorine in PDB 2opm: Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph- 461Enzymatic activity of Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph- 461
All present enzymatic activity of Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph- 461:
2.5.1.10; Protein crystallography data
The structure of Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph- 461, PDB code: 2opm
was solved by
R.Cao,
Y.G.Gao,
H.Robinson,
A.Goddard,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 2opm:
The structure of Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph- 461 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph- 461
(pdb code 2opm). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph- 461, PDB code: 2opm: Fluorine binding site 1 out of 1 in 2opmGo back to Fluorine Binding Sites List in 2opm
Fluorine binding site 1 out
of 1 in the Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate Bph- 461
Mono view Stereo pair view
Reference:
Y.Zhang,
R.Cao,
F.Yin,
M.P.Hudock,
R.T.Guo,
K.Krysiak,
S.Mukherjee,
Y.G.Gao,
H.Robinson,
Y.Song,
J.H.No,
K.Bergan,
A.Leon,
L.Cass,
A.Goddard,
T.K.Chang,
F.Y.Lin,
E.Van Beek,
S.Papapoulos,
A.H.Wang,
T.Kubo,
M.Ochi,
D.Mukkamala,
E.Oldfield.
Lipophilic Bisphosphonates As Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-Ray and uc(Nmr) Investigation. J.Am.Chem.Soc. V. 131 5153 2009.
Page generated: Sun Dec 13 11:38:35 2020
ISSN: ISSN 0002-7863 PubMed: 19309137 DOI: 10.1021/JA808285E |
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