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Atomistry » Fluorine » PDB 2oh4-2pdk » 2ops » |
Fluorine in PDB 2ops: Crystal Structure of Y188C Mutant Hiv-1 Reverse Transcriptase in Complex with GW420867X.Enzymatic activity of Crystal Structure of Y188C Mutant Hiv-1 Reverse Transcriptase in Complex with GW420867X.
All present enzymatic activity of Crystal Structure of Y188C Mutant Hiv-1 Reverse Transcriptase in Complex with GW420867X.:
2.7.7.49; Protein crystallography data
The structure of Crystal Structure of Y188C Mutant Hiv-1 Reverse Transcriptase in Complex with GW420867X., PDB code: 2ops
was solved by
J.Ren,
C.E.Nichols,
P.P.Chamberlain,
K.L.Weaver,
S.A.Short,
J.H.Chan,
J.Kleim,
D.K.Stammers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Y188C Mutant Hiv-1 Reverse Transcriptase in Complex with GW420867X.
(pdb code 2ops). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Y188C Mutant Hiv-1 Reverse Transcriptase in Complex with GW420867X., PDB code: 2ops: Fluorine binding site 1 out of 1 in 2opsGo back to Fluorine Binding Sites List in 2ops
Fluorine binding site 1 out
of 1 in the Crystal Structure of Y188C Mutant Hiv-1 Reverse Transcriptase in Complex with GW420867X.
Mono view Stereo pair view
Reference:
J.Ren,
C.E.Nichols,
P.P.Chamberlain,
K.L.Weaver,
S.A.Short,
J.H.Chan,
J.P.Kleim,
D.K.Stammers.
Relationship of Potency and Resilience to Drug Resistant Mutations For GW420867X Revealed By Crystal Structures of Inhibitor Complexes For Wild-Type, LEU100ILE, LYS101GLU, and TYR188CYS Mutant Hiv-1 Reverse Transcriptases. J.Med.Chem. V. 50 2301 2007.
Page generated: Sun Dec 13 11:38:38 2020
ISSN: ISSN 0022-2623 PubMed: 17441703 DOI: 10.1021/JM061117M |
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