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Fluorine in PDB 2p55: X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
Enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
All present enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp:
2.7.12.2;
2.7.12.2;
Protein crystallography data
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp, PDB code: 2p55
was solved by
J.F.Ohren,
A.G.Pavlovsky,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 2.80 |
| Space group | P 62 |
| Cell size a, b, c (Å), α, β, γ (°) | 81.634, 81.634, 129.086, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 22.8 / 30.1 |
Other elements in 2p55:
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp also contains other interesting chemical elements:
| Magnesium | (Mg) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
(pdb code 2p55). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp, PDB code: 2p55:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp, PDB code: 2p55:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 2p55
Go back to
Fluorine Binding Sites List in 2p55
Fluorine binding site 1 out
of 3 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 2p55
Go back to
Fluorine Binding Sites List in 2p55
Fluorine binding site 2 out
of 3 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 2p55
Go back to
Fluorine Binding Sites List in 2p55
Fluorine binding site 3 out
of 3 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp within 5.0Å range:
|
Reference:
J.A.Spicer,
G.W.Rewcastle,
M.D.Kaufman,
S.L.Black,
M.S.Plummer,
W.A.Denny,
J.Quin,
A.B.Shahripour,
S.D.Barrett,
C.E.Whitehead,
J.B.Milbank,
J.F.Ohren,
R.C.Gowan,
C.Omer,
H.S.Camp,
N.Esmaeil,
K.Moore,
J.S.Sebolt-Leopold,
S.Pryzbranowski,
R.L.Merriman,
D.F.Ortwine,
J.S.Warmus,
C.M.Flamme,
A.G.Pavlovsky,
H.Tecle.
4-Anilino-5-Carboxamido-2-Pyridone Derivatives As Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase. J.Med.Chem. V. 50 5090 2007.
ISSN: ISSN 0022-2623
PubMed: 17880056
DOI: 10.1021/JM0704548
Page generated: Sun Dec 13 11:38:46 2020
ISSN: ISSN 0022-2623
PubMed: 17880056
DOI: 10.1021/JM0704548
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